Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

scientific article published on 7 March 2006

Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2006-01-0329
P932PMC publication ID1895845
P698PubMed publication ID16522809
P5875ResearchGate publication ID7255111

P50authorChristopher H. ContagQ55099930
Robert S. NegrinQ110528996
P2093author name stringAndreas Beilhack
Jeanette Baker
Stephan Schulz
Vu H Nguyen
Robert Zeiser
Martin Buess
P2860cites workControl of regulatory T cell development by the transcription factor Foxp3Q27860489
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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.Q34516841
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CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
Shifting foci of hematopoiesis during reconstitution from single stem cellsQ35122188
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsetsQ35847952
Tolerance, not immunity, crucially depends on IL-2.Q35877199
Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.Q36369780
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationQ36402763
Identification of the Immunophilins Capable of Mediating Inhibition of Signal Transduction by Cyclosporin A and FK506: Roles of Calcineurin Binding and Cellular LocationQ36694583
Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cellsQ38323893
Early IL-2 Production by Mouse Dendritic Cells Is the Result of Microbial-Induced PrimingQ40649514
Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia responseQ40651436
Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cellsQ41743877
Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.Q43829312
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factorQ43873032
Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cellsQ44072016
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New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.Q44200460
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockadeQ44217780
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Acceleration of apoptosis in CD4+CD8+ thymocytes by rapamycin accompanied by increased CD4+CD25+ T cells in the peripheryQ44741787
Mycophenolate mofetil does not suppress the graft-versus-leukemia effect or the activity of lymphokine-activated killer (LAK) cells in a murine modelQ45251857
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cellsQ46739924
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor functionQ47579310
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.Q54073234
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Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft toleranceQ57202280
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In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin AQ71029782
Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndromeQ72574737
Combination therapy with a CD4-CDR3 peptide analog and cyclosporin A to prevent graft-vs-host disease in a MHC-haploidentical bone marrow transplantation modelQ74063423
Mycophenolate mofetil impairs the maturation and function of murine dendritic cellsQ74183071
Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance inductionQ74191513
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
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The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethalityQ78033315
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)390-399
P577publication date2006-03-07
P1433published inBloodQ885070
P1476titleInhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
P478volume108