Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis

scientific article published on 27 August 2008

Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M804159200
P932PMC publication ID2576526
P698PubMed publication ID18753136

P50authorMalak KotbQ114318924
Sarah RoweQ51899708
P2093author name stringJenny P-Y Ting
Debra J Taxman
Arthur Geller
Engy Mahrous
Leighton Legros
Lidia A Gardner
Ramy R Attia
P2860cites workCloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II)Q22011144
Criteria for effective design, construction, and gene knockdown by shRNA vectorsQ25256708
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acidQ26778512
S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liverQ28575436
Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cellsQ28646397
S-adenosylmethionine synthesis: molecular mechanisms and clinical implicationsQ28646532
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
PolyaminesQ29615154
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.Q30747325
Methionine metabolism in mammalsQ34366989
S-Adenosylmethionine and methylationQ34382111
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cellsQ34416761
S-Adenosylmethionine: a control switch that regulates liver function.Q34482345
S-adenosylmethionine: jack of all trades and master of everything?Q34503043
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolismQ34546376
Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitorsQ36399540
Inborn errors of sulfur-containing amino acid metabolismQ36479642
Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cellsQ36692913
Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress.Q54587527
Synergistic effect of methionine-depleting total parenteral nutrition with 5-fluorouracil on human gastric cancer: a randomized, prospective clinical trial.Q54979956
S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate.Q55036879
Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humansQ56832817
Inhibitors of ATP: L-methionine S-adenosyltransferase—L-Methionine analoguesQ66920821
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acidsQ66946828
Antigenic conservation of primary structural regions of S-adenosylmethionine synthetaseQ67670885
Toward the synthesis of isozyme-specific enzyme inhibitors. Potent inhibitors of rat methionine adenosyltransferases. Effect of one-atom elongation of the ribose-P alpha bridge in two covalent adducts of L-methionine and beta,gamma-imido-ATPQ68090719
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. 3. Carbocyclic and heterocyclic amino acidsQ69823815
S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterizationQ70073689
Fractionation of methionine adenosyltransferase isozymes (rat liver)Q71048050
Chemotherapeutic potential of methionine analogue inhibitors of tumor-derived methionine adenosyltransferasesQ71725878
Differential regulation of methionine adenosyltransferase in superantigen and mitogen stimulated human T lymphocytesQ73427558
A method for the rapid construction of cRNA standard curves in quantitative real-time reverse transcription polymerase chain reactionQ74177660
A new series of S-adenosyl-L-methionine synthetase inhibitorsQ77481967
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemiaQ80458847
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteinsQ83978389
New therapeutic strategies for the treatment of acute lymphoblastic leukaemiaQ36724661
Pharmacogenetics of acute lymphoblastic leukemia treatment responseQ36968156
CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.Q38351580
Methionine Adenosyltransferase ( S ‐Adenosylmethionine Synthetase) and S ‐Adenosylmethionine DecarboxylaseQ40169467
Methionine adenosyltransferase: structure and functionQ40799580
Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivoQ41059815
Differential kinetic properties of L-2-amino-4-methylthio-cis-but-3-enoic acid, a methionine analog inhibitor of S-adenosylmethionine synthetaseQ41528539
Induction of interleukin 2 production but not methionine adenosyltransferase activity or S-adenosylmethionine turnover in Jurkat T-cellsQ41618528
Methionine dependency of malignant tumors: a possible approach for therapyQ41717912
Approaches to isozyme-specific inhibitors. 16. A novel methyl-C5' covalent adduct of L-ethionine and beta,gamma-imido-ATP as a potent multisubstrate inhibitor of rat methionine adenosyltransferasesQ42199282
Changes in the relative amount of subunits of methionine adenosyltransferase in human lymphocytes upon stimulation with a polyclonal T cell mitogenQ43589260
Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatomaQ44387828
Isozymes of S-adenosylmethionine synthetase from rat liver: isolation and characterizationQ44887169
Consensus nomenclature for the mammalian methionine adenosyltransferase genes and gene productsQ48777148
P433issue45
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
cell growthQ189159
gene silencingQ1431332
P1104number of pages8
P304page(s)30788-30795
P577publication date2008-08-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleSelective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis
P478volume283

Reverse relations

cites work (P2860)
Q39162217Anti-leukemic response of a NSAID, tolfenamic acid.
Q36646416Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.
Q36556335Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells
Q34170057Efficient induction of extrinsic cell death by dandelion root extract in human chronic myelomonocytic leukemia (CMML) cells
Q40873454MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation
Q97570182Neurodegeneration in multiple sclerosis involves multiple pathogenic mechanisms
Q34027272Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21)
Q37418460S-adenosylmethionine limitation induces p38 mitogen-activated protein kinase and triggers cell cycle arrest in G1.
Q27684874Structure and function study of the complex that synthesizesS-adenosylmethionine
Q38214772Targeted nanoparticles for pediatric leukemia therapy
Q38758640Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.

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