Insights into the structure and activity of prototype foamy virus RNase H.

scientific article published on 10 February 2012

Insights into the structure and activity of prototype foamy virus RNase H. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1024667435
P356DOI10.1186/1742-4690-9-14
P932PMC publication ID3305377
P698PubMed publication ID22325739
P5875ResearchGate publication ID221824180

P2093author name stringBirgitta M Wöhrl
Maximilian J Hartl
Kristian Schweimer
Florian Mayr
Berit Leo
P2860cites workDefects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase HQ40063803
Mutations within the RNase H Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Abolish Virus InfectivityQ41706910
AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP.Q41878118
Regulation of foamy virus protease activity by viral RNA: a novel and unique mechanism among retrovirusesQ42089507
Human immunodeficiency virus reverse transcriptase ribonuclease H: specificity of tRNALys3-primer excisionQ43662972
A recombinant ribonuclease H domain of HIV-1 reverse transcriptase that is enzymatically activeQ45275296
The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virusQ45642567
The isolated RNase H domain of murine leukemia virus reverse transcriptase. Retention of activity with concomitant loss of specificityQ45760983
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structuresQ45786850
Importance of the positive charge cluster in Escherichia coli ribonuclease HI for the effective binding of the substrate.Q54695492
A detailed model of reverse transcription and tests of crucial aspectsQ66971643
The basic loop of the RNase H domain of MLV RT is important both for RNase H and for polymerase activityQ73643718
A general two-metal-ion mechanism for catalytic RNAQ24562157
RNase H activity: structure, specificity, and function in reverse transcriptionQ24643032
Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolutionQ27642055
Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcriptionQ27648911
The solution structure of the simian foamy virus protease reveals a monomeric proteinQ27651022
Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl proteinQ27670506
Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptaseQ28646722
Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptaseQ28646744
The sequence features important for plus strand priming by human immunodeficiency virus type 1 reverse transcriptaseQ28646831
Making and breaking nucleic acids: two-Mg2+-ion catalysis and substrate specificityQ29615987
Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysisQ29619064
Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activitiesQ33559415
Association of viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybridsQ34206884
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptaseQ34577497
Crystal structure of the moloney murine leukemia virus RNase H domainQ35024135
Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.Q35155286
RNase H domain of Moloney murine leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificityQ35873623
Contributions of DNA polymerase subdomains to the RNase H activity of human immunodeficiency virus type 1 reverse transcriptaseQ36635062
Purification and characterization of an active human immunodeficiency virus type 1 RNase H domainQ36650031
Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptaseQ36782119
Specificities involved in the initiation of retroviral plus-strand DNAQ36800484
Reconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptaseQ37396397
Molecular biology of foamy virusesQ37743255
Specificity of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H in removal of the minus-strand primer, tRNA(Lys3)Q38327335
Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybridsQ38338374
Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switchingQ38345021
Interaction of the basic protrusion of Escherichia coli ribonuclease HI with its substrateQ38351423
Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptasesQ39525135
Molecular characterization of proteolytic processing of the Pol proteins of human foamy virus reveals novel features of the viral protease.Q39580590
Mutations of the RNase H C helix of the Moloney murine leukemia virus reverse transcriptase reveal defects in polypurine tract recognitionQ39752971
P304page(s)14
P577publication date2012-02-10
P1433published inRetrovirologyQ15793508
P1476titleInsights into the structure and activity of prototype foamy virus RNase H.
P478volume9

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cites work (P2860)
Q42152706AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase
Q42225067Determination of the protease cleavage site repertoire--the RNase H but not the RT domain is essential for foamy viral protease activity
Q33798319Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 RNase H inhibitors
Q91587761Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase
Q42275220Structural requirements for enzymatic activities of foamy virus protease-reverse transcriptase
Q57751843Structure and nucleic acid binding properties of KOW domains 4 and 6-7 of human transcription elongation factor DSIF
Q21245041The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

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