Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC.

scientific article published on November 2014

Nicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.2395
P932PMC publication ID4279388
P698PubMed publication ID25401222
P5875ResearchGate publication ID265907229

P2093author name stringDomenico Coppola
Srikumar P Chellappan
Smitha Pillai
Deepak Perumal
Courtney Schaal
Jonathan Nguyen
P2860cites workNicotine promotes tumor growth and metastasis in mouse models of lung cancerQ21142724
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A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLCQ28387995
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivoQ29619355
Central nicotinic receptors: structure, function, ligands, and therapeutic potential.Q33273397
Precancerous stem cells have the potential for both benign and malignant differentiationQ33278288
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The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancerQ34126960
The SSX family of cancer-testis antigens as target proteins for tumor therapyQ34146229
Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking.Q34180619
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancerQ34421001
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βArrestin-1 and Mcl-1 modulate self-renewal growth of cancer stem-like side-population cells in non-small cell lung cancerQ34589698
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation studyQ34798314
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathwaysQ34803242
Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell linesQ34849133
Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survivalQ35107968
Nuclear localization of γ-tubulin affects E2F transcriptional activity and S-phase progressionQ35497058
Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loopQ36067817
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress modelQ36618617
Nicotine-mediated cell proliferation and angiogenesis: new twists to an old storyQ36653002
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From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathwayQ36989718
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?Q37385793
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Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancerQ39481670
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induce cyclooxygenase-2 activity in human gastric cancer cells: Involvement of nicotinic acetylcholine receptor (nAChR) and beta-adrenergic receptor signaling pathwaysQ39937686
Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF).Q40002656
Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cellsQ40176971
The kit ligand, stem cell factorQ40386264
A human- and male-specific protocadherin that acts through the wnt signaling pathway to induce neuroendocrine transdifferentiation of prostate cancer cells.Q40408972
Stem cell factor as a survival and growth factor in human normal and malignant hematopoiesisQ41013464
Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogeneQ41564993
Requirement for mast cell growth factor for primordial germ cell survival in cultureQ41668856
Prediction of recurrence-free survival in postoperative non-small cell lung cancer patients by using an integrated model of clinical information and gene expressionQ44571511
Stem cell factor is a chemoattractant and a survival factor for CNS stem cellsQ45142298
c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implicationsQ46474874
The Expression of c-kit Protein during Oogenesis and Early Embryonic Development1Q50797507
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.Q53486364
Lung cancerQ73858423
The effect of smoking status on survival following radiation therapy for non-small cell lung cancerQ80081395
New directions in reducing stress effects on cancerQ83394024
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)10486-10502
P577publication date2014-11-01
P1433published inOncotargetQ1573155
P1476titleNicotinic acetylcholine receptors induce c-Kit ligand/Stem Cell Factor and promote stemness in an ARRB1/ β-arrestin-1 dependent manner in NSCLC.
P478volume5

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cites work (P2860)
Q64068836Distinct Prognostic Values of Phospholipase C Beta Family Members for Non-Small Cell Lung Carcinoma
Q58698632Distinct prognostic values of mRNA expression of glutathione peroxidases in non-small cell lung cancer
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Q47129993Genome-wide DNA methylation profiling reveals novel epigenetic signatures in squamous cell lung cancer
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Q55241601In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed.
Q36543364Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation
Q40621763Loss of β-arrestin1 expression predicts unfavorable prognosis for non-small cell lung cancer patients
Q64229777New Routes in GPCR/β-Arrestin-Driven Signaling in Cancer Progression and Metastasis
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