Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein

scientific article published on 20 April 2011

Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/CVI.00055-11
P932PMC publication ID3122619
P698PubMed publication ID21508163
P5875ResearchGate publication ID51065642

P50authorRay BorrowQ64500634
P2093author name stringJamie Findlow
Christoph M Tang
Rachel M Exley
Jay Lucidarme
Lionel Tan
P2860cites workComplete Genome Sequence of Neisseria meningitidis Serogroup B Strain MC58Q22065549
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491Q22122399
Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086Q24654235
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydratesQ27653843
Neisseria meningitidis: an overview of the carriage stateQ28277386
The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complementQ28474974
NeMeSys: a biological resource for narrowing the gap between sequence and function in the human pathogen Neisseria meningitidisQ28749761
Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal diseaseQ58301797
Naturally occurring insertional inactivation of theporAgene ofNeisseria meningitidisby integration of IS1301Q63371254
Multicenter, open-label, randomized phase II controlled trial of an investigational recombinant Meningococcal serogroup B vaccine with and without outer membrane vesicles, administered in infancy.Q64901018
Capsule phase variation in Neisseria meningitidis serogroup B by slipped-strand mispairing in the polysialyltransferase gene (siaD): correlation with bacterial invasion and the outbreak of meningococcal diseaseQ71538870
Distinct mechanisms of interactions of Opc-expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactionsQ71669928
Functional significance of factor H binding to Neisseria meningitidisQ83918204
Infectious diseases associated with complement deficienciesQ30450183
Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.Q33274203
Complement regulators and inhibitory proteinsQ33386110
The influence of IS1301 in the capsule biosynthesis locus on meningococcal carriage and diseaseQ33535924
Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005Q33729202
Independent evolution of the core and accessory gene sets in the genus Neisseria: insights gained from the genome of Neisseria lactamica isolate 020-06.Q33752108
Update on meningococcal disease with emphasis on pathogenesis and clinical managementQ33812435
Epidemiology of meningococcal disease in England and Wales 1993/94 to 2003/04: contribution and experiences of the Meningococcal Reference Unit.Q34537851
Epidemic meningitis, meningococcaemia, and Neisseria meningitidisQ34644525
Complete genome sequence of Neisseria gonorrhoeae NCCP11945.Q34790002
Preclinical evidence for the potential of a bivalent fHBP vaccine to prevent Neisseria meningitidis Serogroup C DiseaseQ36009616
Deletion of the meningococcal fetA gene used for antigen sequence typing of invasive and commensal isolates from Germany: frequencies and mechanismsQ36098684
A universal vaccine for serogroup B meningococcusQ36101910
Vaccination against Neisseria meningitidis using three variants of the lipoprotein GNA1870Q36370598
Defining targets for complement components C4b and C3b on the pathogenic neisseriaeQ36422066
The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistanceQ36470692
The Stonehouse survey: nasopharyngeal carriage of meningococci and Neisseria lactamicaQ36472571
Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidisQ36491155
A generic mechanism in Neisseria meningitidis for enhanced resistance against bactericidal antibodiesQ36699790
Interactions between Neisseria meningitidis and the complement system.Q36775957
Vaccine potential of the Neisseria meningitidis 2086 lipoproteinQ37115883
Complement evasion strategies of pathogens-acquisition of inhibitors and beyondQ37499399
Genome flexibility in Neisseria meningitidisQ37499451
Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidisQ38326601
Variation of the factor H-binding protein of Neisseria meningitidisQ38350786
Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulenceQ39667409
Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcusQ39981028
Characterization of fHbp, nhba (gna2132), nadA, porA, and sequence type in group B meningococcal case isolates collected in England and Wales during January 2008 and potential coverage of an investigational group B meningococcal vaccineQ41012990
Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.Q41825787
Characterization of fHbp, nhba (gna2132), nadA, porA, sequence type (ST), and genomic presence of IS1301 in group B meningococcal ST269 clonal complex isolates from England and WalesQ41845489
Highly conserved Neisseria meningitidis surface protein confers protection against experimental infectionQ41966979
Transcellular passage of Neisseria meningitidis across a polarized respiratory epitheliumQ42428389
Two-partner secretion systems of Neisseria meningitidis associated with invasive clonal complexesQ42664149
Global epidemiology of meningococcal disease.Q44677055
Sequence diversity of the factor H binding protein vaccine candidate in epidemiologically relevant strains of serogroup B Neisseria meningitidisQ46777542
Contribution of genes from the capsule gene complex (cps) to lipooligosaccharide biosynthesis and serum resistance in Neisseria meningitidis.Q48084641
Characterization of ST-4821 complex, a unique Neisseria meningitidis clone.Q50857953
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal diseaseQ56880540
Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd ImmunityQ57531180
P433issue6
P921main subjectNeisseria meningitidisQ154625
P304page(s)1002-1014
P577publication date2011-04-20
P1433published inClinical and Vaccine ImmunologyQ5133811
P1476titleCharacterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein
P478volume18

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cites work (P2860)
Q57588792A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: Results of a randomised, controlled, dose-escalation phase 1 trial
Q36521563A meningococcal NOMV-FHbp vaccine for Africa elicits broader serum bactericidal antibody responses against serogroup B and non-B strains than a licensed serogroup B vaccine
Q38132262A multicomponent serogroup B meningococcal vaccine is licensed for use in Europe: what do we know, and what are we yet to learn?
Q38235428A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants
Q38200261A vaccine against serogroup B Neisseria meningitidis: dealing with uncertainty
Q37994540Bexsero: a multicomponent vaccine for prevention of meningococcal disease.
Q35965207Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine
Q98905790Broad vaccine protection against Neisseria meningitidis using factor H binding protein
Q35708801Characterization of invasive Neisseria meningitidis strains from Québec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets
Q36936278Conservation of meningococcal antigens in the genus Neisseria
Q34916886Distinct binding and immunogenic properties of the gonococcal homologue of meningococcal factor h binding protein
Q37124721Does binding of complement factor H to the meningococcal vaccine antigen, factor H binding protein, decrease protective serum antibody responses?
Q30234958Emerging experience with meningococcal serogroup B protein vaccines
Q92951277Estimated susceptibility of Canadian meningococcal B isolates to a meningococcal serogroup B vaccine (MenB-FHbp)
Q36684761Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined
Q37267074Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis
Q38674983Frequent capsule switching in 'ultra-virulent' meningococci - Are we ready for a serogroup B ST-11 complex outbreak?
Q42287840Functional impacts of the diversity of the meningococcal factor H binding protein
Q45097394Gene variability and degree of expression of vaccine candidate factor H binding protein in clinical isolates of Neisseria meningitidis
Q37469617Genetic distribution of noncapsular meningococcal group B vaccine antigens in Neisseria lactamica
Q92929424Genetic variability of Polish serogroup B meningococci (2010-2016) including the 4CMenB vaccine component genes
Q35108361Genotypic analysis of meningococcal factor h-binding protein from non-culture clinical specimens
Q33602953Inhibition of the alternative pathway of nonhuman infant complement by porin B2 contributes to virulence of Neisseria meningitidis in the infant rat model
Q35845900Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009.
Q34376049LOS oligosaccharide modification enhances dendritic cell responses to meningococcal native outer membrane vesicles expressing a non-toxic lipid A
Q37002310Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H.
Q33609246Meningococcal Serogroup B Bivalent rLP2086 Vaccine Elicits Broad and Robust Serum Bactericidal Responses in Healthy Adolescents.
Q34376170Meningococcal disease and the complement system
Q35773926Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein
Q41673949Neisseria cinerea expresses a functional factor H binding protein which is recognised by immune responses elicited by meningococcal vaccines.
Q38183156Neisseria meningitidis B vaccines: recent advances and possible immunization policies.
Q38363907Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.
Q92743045Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent
Q37690815New versus old meningococcal group B vaccines: how the new ones may benefit infants & toddlers
Q39466320Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment
Q52361221Prevalence and genetic characteristics of 4CMenB and rLP2086 vaccine candidates among Neisseria meningitidis serogroup B strains, China.
Q40274755Prevalence of factor H Binding Protein sub-variants among Neisseria meningitidis in China
Q26995760Role of factor H binding protein in Neisseria meningitidis virulence and its potential as a vaccine candidate to broadly protect against meningococcal disease
Q40287703Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2 trial
Q38335257The Long Road to an Effective Vaccine for Meningococcus Group B (MenB).
Q35989852The new multicomponent vaccine against meningococcal serogroup B, 4CMenB: immunological, functional and structural characterization of the antigens
Q38677309The next chapter for group B meningococcal vaccines
Q35936064The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci
Q38864097Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae
Q38538836Vaccines for prevention of group B meningococcal disease: Not your father's vaccines
Q42223921Variability of genes encoding surface proteins used as vaccine antigens in meningococcal endemic and epidemic strain panels from Norway
Q36911374ZnuD, a potential candidate for a simple and universal Neisseria meningitidis vaccine
Q37130358fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations.

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