Effects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes

scientific article published on 4 August 2012

Effects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00441-012-1475-8
P698PubMed publication ID22864983
P5875ResearchGate publication ID230620022

P2093author name stringChristian Zuppinger
Thomas M Suter
Francesco Timolati
Maria-Iris Romay-Ogando
Polychronis Dimitrakis
P2860cites workAggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteinsQ46394496
Atrogin-1 ubiquitin ligase is upregulated by doxorubicin via p38-MAP kinase in cardiac myocytesQ46696596
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesQ23757358
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult miceQ24632487
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cellsQ24671346
Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titinQ27643507
The ubiquitin-proteasome system in cardiac physiology and pathologyQ28299196
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte deathQ28579471
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicinQ33540751
Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy.Q33699632
Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?Q34102834
Autophagy: cellular and molecular mechanismsQ34103624
Autophagy: assays and artifactsQ34341096
Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytesQ34576324
Autophagy as a therapeutic target in cardiovascular diseaseQ35223861
Cardiac autophagy is a maladaptive response to hemodynamic stressQ35839989
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.Q35869405
New insights into doxorubicin-induced cardiotoxicity: the critical role of cellular energetics.Q36552392
Tuning flux: autophagy as a target of heart disease therapyQ36714637
Role of mtDNA lesions in anthracycline cardiotoxicityQ36891738
Protein quality control and degradation in cardiomyocytesQ36952213
Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagyQ37012635
The role of autophagy in the heart.Q37325466
The role of cell death and myofibrillar damage in contractile dysfunction of long-term cultured adult cardiomyocytes exposed to doxorubicinQ37480989
Role of autophagy in heart failure associated with agingQ37728936
Anthracycline cardiotoxicity in the elderly cancer patient: a SIOG expert position paper.Q37801220
Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1.Q39505410
Protein metabolism of the heartQ40170901
Cardiac toxicity 4 to 20 years after completing anthracycline therapyQ41142694
Doxorubicin-induced apoptosis in spontaneously hypertensive rats: differential effects in heart, kidney and intestine, and inhibition by ICRF-187.Q42552722
Adriamycin cardiotoxicityQ42583095
Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured cardiac myocytesQ43153846
Calcium signaling mechanisms in dedifferentiated cardiac myocytes: comparison with neonatal and adult cardiomyocytes.Q43811952
Age-dependent declines in proteasome activity in the heartQ43857550
Myocytes die by multiple mechanisms in failing human heartsQ44370216
P433issue2
P921main subjectdoxorubicinQ18936
autophagyQ288322
ubiquitin-proteasome systemQ47175589
P304page(s)361-372
P577publication date2012-08-04
P1433published inCell and Tissue ResearchQ1524113
P1476titleEffects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes
P478volume350

Reverse relations

cites work (P2860)
Q899677983D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids
Q36466224Advanced Glycation End Products (AGE) Potently Induce Autophagy through Activation of RAF Protein Kinase and Nuclear Factor κB (NF-κB).
Q39120233Autophagic homeostasis is required for the pluripotency of cancer stem cells
Q39264180Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity.
Q33573823Cardiomyocyte autophagy and cancer chemotherapy
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Q37116964Development and testing of gold nanoparticles for drug delivery and treatment of heart failure: a theranostic potential for PPP cardiology
Q36869450Doxorubicin Blocks Cardiomyocyte Autophagic Flux by Inhibiting Lysosome Acidification.
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Q32872193Exercise and Doxorubicin Treatment Modulate Cardiac Mitochondrial Quality Control Signaling.
Q89964455Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy
Q33660939Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction.
Q30090238PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway
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