A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions

scientific article published on 11 July 2009

A small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions is …
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scholarly articleQ13442814

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P356DOI10.1007/S00018-009-0080-9
P698PubMed publication ID19593531

P2093author name stringYoshitaka Tanaka
Yuko Hirota
P2860cites workSerological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA libraryQ22254663
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of ParkinQ24291412
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient miceQ24303752
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagyQ24312147
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processingQ24597817
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Mutant Rab24 GTPase is targeted to nuclear inclusionsQ24792201
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Rab proteins as membrane organizersQ27860861
The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiaeQ27933374
Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamilyQ28116201
Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceQ28131756
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitinationQ42833939
Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24.Q44016477
Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells.Q44163313
MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis.Q44412861
α-Synuclein Is Degraded by Both Autophagy and the ProteasomeQ44420467
Rab7 is required for the normal progression of the autophagic pathway in mammalian cellsQ44892471
Autophagy regulates the processing of amino terminal huntingtin fragmentsQ45291371
Rapamycin alleviates toxicity of different aggregate-prone proteinsQ45299514
Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cellsQ46765808
Molecular and functional characterization of a unique Rab protein, RABRP1, containing the WDIAGQE sequence in a GTPase motifQ48279975
The 26S proteasome assembly is regulated by a maturation-inducing hormone in starfish oocytesQ48924870
Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP.Q50734471
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytesQ72466171
Synthesis and structure-activity relationships of bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPaseQ74583527
mTOR kinase and the regulatory subunit of protein kinase A (PRKAR1A) spatially and functionally interact during autophagosome maturationQ79495018
RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomasQ82931859
Loss of autophagy in the central nervous system causes neurodegeneration in miceQ28131804
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseQ28261987
The roles of intracellular protein-degradation pathways in neurodegenerationQ28269322
Autophagy and signaling: their role in cell survival and cell deathQ28278893
Aggresomes: a cellular response to misfolded proteinsQ28292275
Studies on the mechanisms of autophagy: formation of the autophagic vacuoleQ28565520
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceQ28588080
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
Development by self-digestion: molecular mechanisms and biological functions of autophagyQ29547880
Autophagy as a regulated pathway of cellular degradationQ29547914
A Unified Nomenclature for Yeast Autophagy-Related GenesQ29618950
Rab7: a key to lysosome biogenesisQ29620369
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagyQ29622819
Role for Rab7 in maturation of late autophagic vacuolesQ30014819
Nuclear aggresomes form by fusion of PML-associated aggregates.Q30476220
Small molecule regulators of autophagy identified by an image-based high-throughput screenQ33306309
Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesiclesQ33604281
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradationQ33947993
Autophagosome formation in mammalian cellsQ33964242
Molecular cloning, bacterial expression and properties of Rab31 and Rab32.Q34108809
The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.Q34135152
Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeastQ34550647
A role for Rab5 activity in the biogenesis of endosomal and lysosomal compartmentsQ34700073
Autophagy: a barrier or an adaptive response to cancer.Q35078446
Autophagy as a cell death and tumor suppressor mechanismQ35743138
Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiaeQ36017028
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymesQ36119125
Physiological functions of Atg6/Beclin 1: a unique autophagy-related proteinQ36950921
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradationQ38720406
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localizationQ40154056
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.Q40179972
Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing ParkinQ40195899
Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiencyQ40233725
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagyQ40250473
rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosomeQ40352439
Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutationsQ40437542
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's diseaseQ40540062
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamicsQ40709834
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cellsQ41031244
Rab32 regulates melanosome transport in Xenopus melanophores by protein kinase a recruitmentQ41846660
The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathyQ41917623
Expression of autophagy-associated genes in skeletal muscle: an experimental model of chloroquine-induced myopathyQ41942577
Molecular characterization of rabE, a developmentally regulated Dictyostelium homolog of mammalian rab GTPasesQ42692569
P433issue17
P921main subjectautophagyQ288322
vacuoleQ127702
P304page(s)2913-2932
P577publication date2009-07-11
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleA small GTPase, human Rab32, is required for the formation of autophagic vacuoles under basal conditions
P478volume66

Reverse relations

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