The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki

scientific article published on November 1995

The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ3120223
P932PMC publication ID1136248
P698PubMed publication ID7492316
P5875ResearchGate publication ID15707417

P2093author name stringK S Authi
X Lu
V V Kakkar
S Rahman
P2860cites workThe solution structure of echistatin: evidence for disulphide bond rearrangement in homologous snake toxinsQ67584036
The residues AGDV of recombinant gamma chains of human fibrinogen must be carboxy-terminal to support human platelet aggregationQ67816277
Triflavin, an antiplatelet Arg-Gly-Asp-containing peptide, is a specific antagonist of platelet membrane glycoprotein IIb-IIIa complexQ67932037
Halysin, an antiplatelet Arg-Gly-Asp-containing snake venom peptide, as fibrinogen receptor antagonistQ67968035
Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatusQ67980883
Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIaQ68068771
Elegantin and albolabrin purified peptides from viper venoms: homologies with the RGDS domain of fibrinogen and von Willebrand factorQ68517750
The interaction of thrombospondin with platelet glycoprotein GPIIb-IIIaQ69394865
Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesionQ70073692
The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated plateletsQ70101386
Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to plateletsQ70181883
Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chainQ70211601
Beta 3 integrin derived peptide 217-230 inhibits fibrinogen binding and platelet aggregation: significance of RGD sequences and fibrinogen A alpha-chainQ70534304
Dendroaspin: a potent integrin receptor inhibitor from the venoms of Dendroaspis viridis and D. jamesoniiQ70599880
Two-step binding mechanism of fibrinogen to alpha IIb beta 3 integrin reconstituted into planar lipid bilayersQ70614647
Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand bindingQ71655421
Localization of a site interacting with human platelet receptor on carboxy-terminal segment of human fibrinogen γ chainQ72956213
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa AntagonistQ27651187
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspinQ27729807
The nuclear magnetic resonance solution structure of flavoridin, an antagonist of the platelet GP IIb-IIIa receptorQ27731981
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouriQ28277512
A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectinQ28645680
Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitorsQ33404652
Platelets have more than one binding site for von Willebrand factorQ33821754
Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activationQ34313515
Ligand binding to GPIIb-IIIa: a status reportQ35557147
Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granulesQ35823997
Apparent competitive inhibition of radioligand binding to receptors: experimental and theoretical considerations in the analysis of equilibrium binding dataQ36438256
Monoclonal antibody characterization of two distant sites required for function of the central cell-binding domain of fibronectin in cell adhesion, cell migration, and matrix assemblyQ36530275
Role of fibrinogen alpha and gamma chain sites in platelet aggregationQ37294912
The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to plateletsQ37556824
Multiple adenovirus serotypes use alpha v integrins for infectionQ38303569
Quantitative aspects of hormone-receptor interactions of high affinity. Effect of receptor concentration and measurement of dissociation constants of labeled and unlabeled hormonesQ39961137
Animal-derived antigenic variants of foot-and-mouth disease virus type A12 have low affinity for cells in culture.Q40038672
Integrin-mediated cell adhesion: the extracellular faceQ40634053
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clusteringQ41517769
Some properties and the complete primary structures of two reduced and S-carboxymethylated polypeptides (S5C1 and S5C10) from Dendroaspis jamesoni kaimosae (Jameson's mamba) venomQ41725610
Interaction of disintegrins with the alpha IIb beta 3 receptor on resting and activated human plateletsQ41848646
Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RQ41975301
Synthetic RGD peptides derived from the adhesive domains of snake-venom proteins: evaluation as inhibitors of platelet aggregationQ42254956
Characterization of the integrin specificities of disintegrins isolated from American pit viper venomsQ43479171
A discrete sequence in a platelet integrin is involved in ligand recognitionQ43578287
A peptide corresponding to GPIIb alpha 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligandsQ44954631
Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: analysis by site-directed mutagenesis.Q46029368
Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function.Q46029496
Arginine-glycine-aspartic acid binding leading to molecular stabilization between integrin alpha v beta 3 and its ligandQ46068540
Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxinsQ46212293
Integrin alpha IIb beta 3 (platelet GPIIb-IIIa) recognizes multiple sites in fibronectin.Q46493640
Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIaQ46619536
Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complexQ47189435
Clues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex.Q50695257
Ligand dissociation constants from competition binding assays: errors associated with ligand depletion.Q52595243
P407language of work or nameEnglishQ1860
P921main subjectsnake venomQ424200
P304page(s)223-232
P577publication date1995-11-01
P1433published inBiochemical JournalQ864221
P1476titleThe integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki
P478volume312 ( Pt 1)

Reverse relations

cites work (P2860)
Q58058093An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity
Q34974087Application of Recombinant Rhodostomin in Studying Cell Adhesion
Q27011302Applications of snake venom components to modulate integrin activities in cell-matrix interactions
Q39933322Colombistatin: a disintegrin isolated from the venom of the South American snake (Bothrops colombiensis) that effectively inhibits platelet aggregation and SK-Mel-28 cell adhesion.
Q41778652Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery
Q45856540Identification of a novel mutation in a non-Jewish factor XI deficient kindred
Q42249278Immunological characterization of eristostatin and echistatin binding sites on alpha IIb beta 3 and alpha V beta 3 integrins
Q40864152Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin
Q74579244Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity
Q41769202Modulation of RGD sequence motifs regulates disintegrin recognition of alphaIIb beta3 and alpha5 beta1 integrin complexes. Replacement of elegantin alanine-50 with proline, N-terminal to the RGD sequence, diminishes recognition of the alpha5 beta1 c
Q28367196Positional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin alphaIIbbeta3
Q43443916Snake venoms and the hemostatic system
Q45076939Solution structure of gamma-bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding
Q73803111Structural analysis of the KGD sequence loop of barbourin, an alphaIIbbeta3-specific disintegrin
Q51803883The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.
Q43742778The inhibition of platelet aggregation and blood coagulation by Micropechis ikaheka venom
Q74552056The role of glycoproteins in neural development function, and disease
Q24291476Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites

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