Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

scientific article published on June 2015

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/STEM.1975
P932PMC publication ID4737234
P698PubMed publication ID25693948

P50authorStephen D. ThorpeQ54352091
Paul ChappleQ64932394
Martin M KnightQ42395269
John T ConnellyQ47502286
P2093author name stringMelis T Dalbay
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Cilia and the cell cycle?Q24678836
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Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesisQ28476413
Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesisQ28488225
A role for the primary cilium in Notch signaling and epidermal differentiation during skin developmentQ28510710
The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesisQ28513239
Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytesQ28585724
Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia.Q50637861
Mechanical loading modulates chondrocyte primary cilia incidence and length.Q53346455
Primary cilia and signaling pathways in mammalian development, health and disease.Q55443025
IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathwaysQ28593506
The primary cilium: a signalling centre during vertebrate developmentQ29547197
Patched1 regulates hedgehog signaling at the primary ciliumQ29547515
CiliopathiesQ29614821
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Primary cilia-mediated mechanotransduction in human mesenchymal stem cellsQ30530971
Flagellar length control system: testing a simple model based on intraflagellar transport and turnoverQ33564793
The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartmentQ33858596
Roles of PPARs in health and disease.Q33934899
The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage CommitmentQ34094901
Cell shape and contractility regulate ciliogenesis in cell cycle-arrested cells.Q34218824
Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney diseaseQ36156370
The primary cilium at a glanceQ37690035
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and ciliaQ37834841
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.Q38788566
Activation of hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells.Q39903557
Insulin but not IGF-I is required for the maintenance of the adipose phenotype in the adipogenic cell line 1246.Q40909416
Identification of signaling pathways regulating primary cilium length and flow-mediated adaptationQ41579424
Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells.Q41995406
Primary cilia mediate sonic hedgehog signaling to regulate neuronal-like differentiation of bone mesenchymal stem cells for resveratrol induction in vitroQ42707166
Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytesQ42803238
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Regulation of fibronectin, integrin and cytoskeleton expression in differentiating adipocytes: inhibition by extracellular matrix and polylysineQ42834581
TGF-β signaling is associated with endocytosis at the pocket region of the primary ciliumQ44200736
Vertebrate primary cilia: a sensory part of centrosomal complex in tissue cells, but a "sleeping beauty" in cultured cells?Q44776951
Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytesQ44968839
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P304page(s)1952-1961
P577publication date2015-06-01
P1433published inStem CellsQ15724411
P1476titleAdipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation
P478volume33

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cites work (P2860)
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Q64118585Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes
Q92235439Human chromatin remodeler cofactor, RNA interactor, eraser and writer sperm RNAs responding to obesity
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Q94481867Prdx1 promotes the loss of primary cilia in esophageal squamous cell carcinoma
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Q33848892Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.

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