Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action

scientific article published on 29 April 2011

Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1667/RR2507.1
P932PMC publication ID3118638
P698PubMed publication ID21529145

P50authorMartin Hauer-JensenQ87074114
P2093author name stringJunru Wang
Qiang Fu
Wenze Wang
Marjan Boerma
Herbert A Schmid
Maaike Berbée
P2860cites workThe synthetic somatostatin analogue, octreotide, ameliorates acute and delayed intestinal radiation injuryQ73307162
The nature of intestinal radiation deathQ73985374
Effects of growth hormone and insulin-like growth factor-I on radiation enteritis. a comparative studyQ77218612
Human Mig chemokine: biochemical and functional characterizationQ24678720
Interleukin 1 is a radioprotectorQ28299497
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Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cellsQ33337708
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The role of the gastrointestinal tract in postinjury multiple organ failureQ33835696
Determination of sample sizes for demonstrating efficacy of radiation countermeasuresQ34565829
The hematologist and radiation casualties.Q35591475
A new hypothesis for microvascular inflammation in shock and multiorgan failure: self-digestion by pancreatic enzymesQ36086355
Human mast cells, bacteria, and intestinal immunityQ36819955
The gastrointestinal tract stem cell nicheQ36877550
Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and managementQ37228299
Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell deathQ37446172
The antiproliferative effect of somatostatin analogs: clinical relevance in patients with neuroendocrine gastro-entero-pancreatic tumours.Q37464055
History and development of radiation-protective agentsQ37532178
Role of Pancreatic Proteases in the Pathogenesis of Ischemic EnteropathyQ39148083
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.Q41175127
Effect of octreotide acetate on pancreatic exocrine functionQ41256214
The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretionQ42553872
SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profileQ43973971
The efficacy of octreotide in the therapy of acute radiation-induced diarrhea: a randomized controlled studyQ44105608
Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.Q45872659
Novel role of the CXC chemokine receptor 3 in inflammatory response to arterial injury: involvement of mTORC1.Q46212010
Pharmacokinetic-pharmacodynamic comparison of a novel multiligand somatostatin analog, SOM230, with octreotide in patients with acromegalyQ46589238
Induction of cytokines by radioprotective tocopherol analogsQ46903824
Growth hormone reduces mortality and bacterial translocation in irradiated rats.Q47943330
The substance P and somatostatin interferon-gamma immunoregulatory circuitQ47966509
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.Q54593964
Local administration of interleukin-11 ameliorates intestinal radiation injury in ratsQ57216391
Effect of Somatostatin on Normal and Gastric-Stimulated Cell Proliferation in the Gastric and Intestinal Mucosae of the RatQ66924500
Effect of somatostatin on pancreatic enzyme secretionQ69052839
Influence of pancreatic secretion on late radiation enteropathy in the ratQ70131456
Prolongation of survival in lethally irradiated dogs by pancreatic duct ligationQ71592276
Injurious Effect of Pancreatic Secretions on Postradiation EnteropathyQ72327296
Intestinal permeability in humans is increased after radiation therapyQ73218703
P433issue6
P304page(s)728-735
P577publication date2011-04-29
P1433published inRadiation ResearchQ2446628
P1476titlePreclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action
P478volume175

Reverse relations

cites work (P2860)
Q27021962Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles
Q37450663Gamma-tocopherol-N,N-dimethylglycine ester as a potent post-irradiation mitigator against whole body X-irradiation-induced bone marrow death in mice
Q35566671Medical Countermeasures for Radiation Exposure and Related Injuries: Characterization of Medicines, FDA-Approval Status and Inclusion into the Strategic National Stockpile.
Q26823881Novel drugs to ameliorate gastrointestinal normal tissue radiation toxicity in clinical practice: what is emerging from the laboratory?
Q35626587Radiation countermeasure agents: an update (2011-2014)
Q28237189Radiation enteropathy--pathogenesis, treatment and prevention
Q37006942Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice
Q64925139The effect of pasireotide on intestinal anastomotic healing with and without whole-body irradiation in a rat model.
Q48072002Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates.

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