Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

scientific article published on 8 August 2008

Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1038574619
P356DOI10.1186/1742-4682-5-19
P932PMC publication ID2542356
P698PubMed publication ID18687151
P5875ResearchGate publication ID23156003

P2093author name stringHirotaka Ando
Ippei Nakagawa
Wataru Hori
Shigeru Izawa
P2860cites workExtrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronideQ30747312
Allometric scaling of pharmacokinetic parameters in drug discovery: can human CL, Vss and t1/2 be predicted from in-vivo rat data?Q30940461
Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approachesQ30984976
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlationsQ34529915
Clinical pharmacokinetics of epidural and spinal anaesthesiaQ38657879
Role of the enterohepatic circulation in the elimination of phenytoin in the ratQ39178820
Prediction of the disposition of nine weakly acidic and six weakly basic drugs in humans from pharmacokinetic parameters in ratsQ39851158
Physiological parameter values for physiologically based pharmacokinetic modelsQ41556435
The disposition of gemifloxacin, a new fluoroquinolone antibiotic, in rats and dogs.Q43548044
Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.Q43740204
Prediction of the disposition of midazolam in surgical patients by a physiologically based pharmacokinetic modelQ43824833
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoproteinQ43850599
Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug dispositionQ43971739
Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation methodQ44068573
Effect of glycerol-induced acute renal failure on the pharmacokinetics of lidocaine after transdermal application in ratsQ44545881
Reduction and lumping of physiologically based pharmacokinetic models: prediction of the disposition of fentanyl and pethidine in humans by successively simplified modelsQ44676689
Effects of cimetidine on lidocaine distribution in ratsQ45164355
Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasmaQ46750037
Drug interactions between imipramine and benzodiazepines in ratsQ48161609
Prediction of metabolic drug clearance in humans: in vitro-in vivo extrapolation vs allometric scalingQ48463862
Kinetic evaluation for measurement of in vivo receptor occupancy by psychotropic drug in brain: implication for human studiesQ48704138
The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and manQ48797060
Physiologically based pharmacokinetics of drug-drug interaction: a study of tolbutamide-sulfonamide interaction in ratsQ48934163
Dose-independent pharmacokinetics of intravenous lidocaine in humans.Q51854434
Biotransformation of [14C]midazolam in the ratin vitroandin vivoQ51867270
Mechanistic approaches to volume of distribution predictions: understanding the processes.Q51919468
Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.Q51975107
Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection.Q52408256
Biliary excretion of diazepam in the rat.Q52722114
Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.Q52722509
A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.Q52963239
A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.Q52963243
Prediction of human pharmacokinetics using physiologically based modeling: a retrospective analysis of 26 clinically tested drugs.Q53024733
Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.Q54483675
Kinetic analysis of phenytoin disposition in rats with experimental renal and hepatic diseasesQ67935208
Imipramine and desipramine disposition in the elderlyQ70045130
The metabolism and excretion of [14C]imipramine in an experimental hepatitisQ70604354
[Absorption, distribution, excretion and metabolism of [14C] T-3761 in rats and mice]Q71964063
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in ratsQ74294325
Physiologically-based pharmacokinetic analysis of grepafloxacinQ74330428
Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to manQ81445372
Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro-in vivo extrapolations (IVIVE)Q81516853
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokineticsQ83169875
A novel strategy for physiologically based predictions of human pharmacokineticsQ83204523
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P921main subjectpharmacokineticsQ323936
P304page(s)19
P577publication date2008-08-08
P1433published inTheoretical Biology and Medical ModellingQ15750144
P1476titleUtility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling
P478volume5

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cites work (P2860)
Q51218938Altered tolbutamide pharmacokinetics by a decrease in hepatic expression of CYP2C6/11 in rats pretreated with 5-fluorouracil.
Q34034839An analysis of whole body tracer kinetics in dynamic PET studies with application to image-based blood input function extraction
Q47588877Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients
Q55226306Correction: Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling.
Q89842080Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone-releasing hormone

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