The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae

scientific article published on December 2009

The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M109.062844
P932PMC publication ID2825406
P698PubMed publication ID19951944

P50authorChris M GrantQ37836530
P2093author name stringIan W Dawes
Sebastian Raeth
Darren Greetham
Gabriel G Perrone
Shi-Xiong Tan
P2860cites workThe NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in ArabidopsisQ24651469
Transformation of intact yeast cells treated with alkali cationsQ24672708
Structural and kinetic analysis of Saccharomyces cerevisiae thioredoxin Trx1: implications for the catalytic mechanism of GSSG reduced by the thioredoxin systemQ27654659
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysisQ27860815
A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistanceQ27930394
Molecular cloning of the gamma-glutamylcysteine synthetase gene of Saccharomyces cerevisiaeQ27930911
Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1pQ27931231
Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae.Q27932221
Glutathione is an important antioxidant molecule in the yeast Saccharomyces cerevisiaeQ27932333
Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae.Q27933589
Biochemical characterization of yeast mitochondrial Grx5 monothiol glutaredoxin.Q27933759
The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species.Q27933841
Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycleQ27934271
Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymesQ27934525
Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiaeQ27934787
Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiaeQ27935005
Oxidative stress response in yeast: effect of glutathione on adaptation to hydrogen peroxide stress in Saccharomyces cerevisiae.Q27938666
Saccharomyces cerevisiae Grx6 and Grx7 are monothiol glutaredoxins associated with the early secretory pathwayQ27939019
Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase.Q27939130
A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettesQ28131622
Substitution of the thioredoxin system for glutathione reductase in Drosophila melanogasterQ28142820
GlutathioneQ28261279
Thioredoxin and glutaredoxin systemsQ28271236
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione coupleQ29615232
Biochemical and genetic analysis of the yeast proteome with a movable ORF collectionQ29619667
ThioredoxinQ29619691
Oxidized redox state of glutathione in the endoplasmic reticulumQ29619789
A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiaeQ33288422
Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductaseQ34283812
Monothiol glutaredoxins: a common domain for multiple functions.Q36784368
Reactive oxygen species and yeast apoptosisQ37094126
Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiaeQ37112647
A glutathione reductase mutant of yeast accumulates high levels of oxidized glutathione and requires thioredoxin for growthQ37383386
Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteineQ40387700
Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systemsQ40663854
Size control models of Saccharomyces cerevisiae cell proliferationQ40679350
Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiaeQ40742283
YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxidesQ40790795
Thioredoxin reductase-dependent inhibition of MCB cell cycle box activity in Saccharomyces cerevisiaeQ42440323
Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiaeQ44201202
Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae.Q46640693
Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factorQ46800010
The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited.Q47825616
Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae.Q52519778
Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae.Q54107366
Mismatch Binding Protein-Based Mutation Detection SystemsQ56944697
Construction and use of gene fusions to lacZ (beta-galactosidase) that are expressed in yeastQ70160206
Thioredoxin and thioredoxin reductaseQ71521704
Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulationQ71619411
A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocolQ72112206
Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiaeQ73725875
A single glutaredoxin or thioredoxin gene is essential for viability in the yeast Saccharomyces cerevisiaeQ73874034
Deletion of the Saccharomyces cerevisiae TRR1 gene encoding thioredoxin reductase inhibits p53-dependent reporter gene expressionQ74263605
Preparation and assay of mammalian thioredoxin and thioredoxin reductaseQ77907868
The genetics of disulfide bond metabolismQ77936221
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)6118-6126
P577publication date2009-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae
P478volume285

Reverse relations

cites work (P2860)
Q34412343A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis
Q51127099Age-related oxidative stress and antioxidant capacity in heat-stressed broilers.
Q37651581Analysis of mutants disrupted in bacillithiol metabolism in Staphylococcus aureus.
Q38155951Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae
Q35651454Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans
Q38063935Functions and cellular compartmentation of the thioredoxin and glutathione pathways in yeast.
Q33884284GSR is not essential for the maintenance of antioxidant defenses in mouse cochlea: Possible role of the thioredoxin system as a functional backup for GSR.
Q39278850Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose
Q58753648Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
Q54300412Glutathione reductase from Brassica rapa affects tolerance and the redox state but not fermentation ability in response to oxidative stress in genetically modified Saccharomyces cerevisiae.
Q34094450Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito
Q56980838Glutathionylation of cytosolic glyceraldehyde-3-phosphate dehydrogenase from the model plant Arabidopsis thaliana is reversed by both glutaredoxins and thioredoxins in vitro
Q40758229Identification and characterization of an atypical 2-cys peroxiredoxin from the silkworm, Bombyx mori
Q58605932Inhibition of thioredoxin/thioredoxin reductase induces synthetic lethality in lung cancers with compromised glutathione homeostasis
Q38038606Kluyveromyces lactis: a suitable yeast model to study cellular defense mechanisms against hypoxia-induced oxidative stress.
Q34568264Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation.
Q55285363Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity.
Q92572677Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway
Q39067204Monitoring changes in thioredoxin and over-oxidised peroxiredoxin in response to exercise in humans
Q27939956Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.
Q51620253Newly identified protein Imi1 affects mitochondrial integrity and glutathione homeostasis in Saccharomyces cerevisiae.
Q38851856Novel insights into redox system and the mechanism of redox regulation
Q37299555Plant cytoplasmic GAPDH: redox post-translational modifications and moonlighting properties
Q36071769Potential Application of the Oryza sativa Monodehydroascorbate Reductase Gene (OsMDHAR) to Improve the Stress Tolerance and Fermentative Capacity of Saccharomyces cerevisiae
Q53080996Probing the intracellular glutathione redox potential by in-cell NMR spectroscopy.
Q36057735Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes
Q38523502Role and Regulation of Glutathione Metabolism in Plasmodium falciparum
Q28484655Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism
Q46294171Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death
Q40973989The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress.
Q36795230The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad
Q38673040The oxidation state of the cytoplasmic glutathione redox system does not correlate with replicative lifespan in yeast
Q35863026The response to heat shock and oxidative stress in Saccharomyces cerevisiae
Q34240142Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia.
Q34714625Transcription profile of soybean-root-knot nematode interaction reveals a key role of phythormones in the resistance reaction
Q34399748Transcriptomic analysis of acclimation to temperature and light stress in Saccharina latissima (Phaeophyceae).
Q38905551Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding.

Search more.