Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region

scientific article published on 11 October 2006

Examination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01243-06
P932PMC publication ID1797239
P698PubMed publication ID17035305
P5875ResearchGate publication ID6760620

P50authorJohn V. WilliamsQ55189885
Sharon J. TollefsonQ116679889
James E. Crowe, Jr.Q37366747
P2093author name stringDavid W Wright
Scott A Miller
P2860cites workStructure of the parainfluenza virus 5 F protein in its metastable, prefusion conformationQ45421033
Heptad-repeat regions of respiratory syncytial virus F1 protein form a six-membered coiled-coil complexQ45740595
The paramyxovirus fusion protein forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1 gp41.Q45749386
Structure and function study of paramyxovirus fusion protein heptad repeat peptidesQ46409835
Human metapneumovirus infections in young and elderly adults.Q51685002
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Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modelingQ73944932
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Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolutionQ27617533
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Structural characterization of the human respiratory syncytial virus fusion protein coreQ27628799
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusionQ27631011
Short constrained peptides that inhibit HIV-1 entryQ27639916
Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptidesQ27764897
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibitionQ28317348
Membrane fusion machines of paramyxoviruses: capture of intermediates of fusionQ28345073
Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide regionQ28360391
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infectionQ28369033
Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusionQ28646673
A spring-loaded mechanism for the conformational change of influenza hemagglutininQ28646856
Twilight zone of protein sequence alignmentsQ29614388
Mechanisms of viral membrane fusion and its inhibitionQ29616090
Virus-cell and cell-cell fusionQ30469833
Protein design of an HIV-1 entry inhibitorQ32067748
Mutational analysis of residues in the coiled-coil domain of human immunodeficiency virus type 1 transmembrane protein gp41Q33785997
A newly discovered human pneumovirus isolated from young children with respiratory tract diseaseQ33845279
Mutations in the fusion peptide and adjacent heptad repeat inhibit folding or activity of the Newcastle disease virus fusion proteinQ33853545
Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion proteinQ33855371
Analysis of the genomic sequence of a human metapneumovirusQ34130526
Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and childrenQ35697523
Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusionQ37712954
The modelling of drug responseQ40292814
Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusionQ40666989
Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groupsQ40694024
Paramyxovirus fusion: a hypothesis for changesQ40767649
Fusion protein of the paramyxovirus SV5: destabilizing and stabilizing mutants of fusion activationQ40885459
Peptides corresponding to the heptad repeat sequence of human parainfluenza virus fusion protein are potent inhibitors of virus infectionQ41172119
Heptad breaks in alpha-helical coiled coils: stutters and stammersQ41209193
Studies with cross-linking reagents on the oligomeric form of the paramyxovirus fusion proteinQ41487431
Modelling the structure of the fusion protein from human respiratory syncytial virusQ44009340
Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusionQ44255473
Different from the HIV fusion inhibitor C34, the anti-HIV drug Fuzeon (T-20) inhibits HIV-1 entry by targeting multiple sites in gp41 and gp120.Q45216915
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectHuman metapneumovirusQ743338
P1104number of pages9
P304page(s)141-149
P577publication date2006-10-11
P1433published inJournal of VirologyQ1251128
P1476titleExamination of a fusogenic hexameric core from human metapneumovirus and identification of a potent synthetic peptide inhibitor from the heptad repeat 1 region
P478volume81

Reverse relations

cites work (P2860)
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Q36586874Breaking in: human metapneumovirus fusion and entry
Q99625242Entry Inhibitors: Efficient Means to Block Viral Infection
Q42571145Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
Q35945710Genomic analysis of four human metapneumovirus prototypes
Q38892410HRA2pl peptide: a fusion inhibitor for human metapneumovirus produced in tobacco plants by transient transformation
Q42133760Human metapneumovirus G protein is highly conserved within but not between genetic lineages
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Q37059705Human metapneumovirus small hydrophobic (SH) protein downregulates type I IFN pathway signaling by affecting STAT1 expression and phosphorylation
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