Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

scientific article published on 21 September 2017

Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/TOXINS9100293
P932PMC publication ID5666340
P698PubMed publication ID28934122

P50authorGiorgio FedeleQ56810661
P2093author name stringNela Klimova
Irena Adkins
Peter Sebo
Ilaria Schiavoni
P2860cites workBordetella pertussis Infection in 2-Month-Old Infants Promotes Type 1 T Cell ResponsesQ61766641
Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clonesQ70054755
Bordetella adenylate cyclase toxin mobilizes its beta2 integrin receptor into lipid rafts to accomplish translocation across target cell membrane in two stepsQ21131558
Circulating Th17, Th22, and Th1 cells are increased in psoriasisQ24629315
RTX proteins: a highly diverse family secreted by a common mechanismQ24630254
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)Q24675699
Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin poresQ27346834
Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathwayQ28214681
Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding proteinQ28288262
Third activity of Bordetella adenylate cyclase (AC) toxin-hemolysin. Membrane translocation of AC domain polypeptide promotes calcium influx into CD11b+ monocytes independently of the catalytic and hemolytic activitiesQ28485698
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
Phenotypic and functional features of human Th17 cellsQ29619323
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase ToxinQ30252682
Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxinQ30303150
Bordetella parapertussis Circumvents Neutrophil Extracellular Bactericidal Mechanisms.Q30354234
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3Q30360778
Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infectionQ30416562
Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammationQ30423650
Delivery of large heterologous polypeptides across the cytoplasmic membrane of antigen-presenting cells by the Bordetella RTX hemolysin moiety lacking the adenylyl cyclase domainQ30425161
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.Q30449654
Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxinQ30461145
Pertussis toxin stimulates IL-17 production in response to Bordetella pertussis infection in miceQ30873716
T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussisQ33564283
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopNQ33590435
Attenuated Bordetella pertussis vaccine candidate BPZE1 promotes human dendritic cell CCL21-induced migration and drives a Th1/Th17 response.Q51015773
Phagocyte Impotence Caused by an Invasive Bacterial Adenylate CyclaseQ51198248
TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.Q53013441
Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease.Q53597450
Adjuvant effects of adenylate cyclase toxin of Bordetella pertussis after intranasal immunisation of mice.Q53604684
Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.Q54242346
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.Q55043889
Cell‐Mediated Immunity and Antibody Responses toBordetella pertussisAntigens in Children with a History of Pertussis Infection and in Recipients of an Acellular Pertussis VaccineQ59651744
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzymeQ38590644
Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.Q38652117
Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 PhosphataseQ38886825
Pertussis leukocytosis: mechanisms, clinical relevance and treatmentQ38949809
Bordetella pertussis entry into respiratory epithelial cells and intracellular survivalQ39119096
Adenyl Cyclase in Bordetella pertussis VaccinesQ39160702
Bordetella pertussis virulence factors affect phagocytosis by human neutrophilsQ39514867
Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responsesQ39970329
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussisQ40257250
GTL001, A Therapeutic Vaccine for Women Infected with Human Papillomavirus 16 or 18 and Normal Cervical Cytology: Results of a Phase I Clinical TrialQ40649178
Follicular Helper T CellsQ40780566
Modulation of host immune responses, induction of apoptosis and inhibition of NF-kappaB activation by the Bordetella type III secretion systemQ40894557
Intracellular trafficking of Bordetella pertussis in human macrophagesQ41880823
Both CD4⁺ and CD8⁺ lymphocytes participate in the IFN-γ response to filamentous hemagglutinin from Bordetella pertussis in infants, children, and adultsQ42045089
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP inductionQ42047758
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responsesQ42206141
Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathwaysQ42936693
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussisQ42976933
Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteinsQ43839547
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infectionQ44550891
The adenylate cyclase toxin contributes to the survival of Bordetella pertussis within human macrophagesQ44562622
Bordetella type III secretion and adenylate cyclase toxin synergize to drive dendritic cells into a semimature stateQ44987484
Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigensQ45098739
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.Q45253754
cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C ActivityQ46438457
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cellsQ46490320
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cellsQ46653871
Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin.Q33609798
Role of adenylate cyclase-hemolysin in alveolar macrophage apoptosis during Bordetella pertussis infection in vivo.Q33752641
Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.Q34000735
Bordetella pertussis pathogenesis: current and future challengesQ34383541
Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection modelQ34522858
The role of innate mediators in inflammatory responseQ34636524
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive rufflingQ34844344
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant miceQ35106655
Complement evasion by Bordetella pertussis: implications for improving current vaccinesQ35197120
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.Q35217146
Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine modelQ35220336
Cell-invasive activity of epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of a foreign epitope to CD8+ cytotoxic T cellsQ35441983
Vaccine- and antigen-dependent type 1 and type 2 cytokine induction after primary vaccination of infants with whole-cell or acellular pertussis vaccinesQ35548872
The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responsesQ35582560
Development and function of T helper 1 cellsQ35769454
The adenylate cyclase toxin from Bordetella pertussis--a novel promising vehicle for antigen delivery to dendritic cellsQ35776241
Signaling pathways in Th2 developmentQ35951832
Tuning microenvironments: induction of regulatory T cells by dendritic cellsQ36151935
Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cellsQ36355239
Bordetella adenylate cyclase toxin: a swift saboteur of host defenseQ36365962
A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells.Q36403615
Protective immunity to Bordetella pertussis requires both B cells and CD4(+) T cells for key functions other than specific antibody productionQ36404631
Expanding the effector CD4 T-cell repertoire: the Th17 lineage.Q36449975
Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterizationQ36580106
Debugging how bacteria manipulate the immune response.Q36739044
Foxp3 in control of the regulatory T cell lineageQ36794299
Bordetella pertussis: new concepts in pathogenesis and treatmentQ36839952
Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functionsQ37015041
Bacteria and their toxins tamed for immunotherapyQ37984514
IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection.Q38129869
Adenylate cyclase toxin-hemolysin relevance for pertussis vaccinesQ38236718
Differentiation, regulation and function of Th9 cellsQ38254788
Investigating pertussis toxin and its impact on vaccinationQ38358628
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue10
P921main subjectcellQ7868
enzymeQ8047
pertussisQ134859
infectionQ166231
neutrophilQ188417
dendritic cellQ506253
hemic and immune systemsQ70202933
P577publication date2017-09-21
P1433published inToxinsQ15724569
P1476titleInvasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity
P478volume9

Reverse relations

cites work (P2860)
Q58698342An Introduction to the Toxins Special Issue on the Adenylate Cyclase Toxin
Q90419622Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
Q92711371Bordetella Filamentous Hemagglutinin, a Model for the Two-Partner Secretion Pathway
Q92538598Immunomodulation as a Novel Strategy for Prevention and Treatment of Bordetella spp. Infections
Q90271081Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes
Q92186230Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway
Q90730492Remasking of Candida albicans β-Glucan in Response to Environmental pH Is Regulated by Quorum Sensing
Q64249913The Adenylate Cyclase (CyaA) Toxin from Has No Detectable Phospholipase A (PLA) Activity In Vitro

Search more.