Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice

scientific article published on January 2013

Sustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3943358
P698PubMed publication ID24611135

P2093author name stringNelson Fausto
Terrance J Kavanagh
Jean S Campbell
Kimberly J Riehle
Jamil Haque
Ryan S McMahan
P2860cites workGlutathione-deficient mice are susceptible to TCDD-Induced hepatocellular toxicity but resistant to steatosisQ42723867
Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease.Q43264434
Toll-like receptor 3 signaling attenuates liver regenerationQ45885253
Changes in glutathione homeostasis during liver regeneration in the rat.Q46260844
Reduced liver injury in the interleukin-6 knockout mice by chronic carbon tetrachloride administration.Q46678896
Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.Q51795776
NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration.Q54064832
Liver regenerationQ55883809
Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4Q82459185
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Regulation of glutathione synthesisQ24655260
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase betaQ28390372
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistanceQ28505114
Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress responseQ28507715
Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygousQ28508176
Glutamate-cysteine ligase attenuates TNF-induced mitochondrial injury and apoptosisQ28509634
Mechanism and significance of increased glutathione level in human hepatocellular carcinoma and liver regenerationQ31635948
Redox regulation of tumor necrosis factor signalingQ33644327
Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activityQ34206940
Mediators of inflammation and acute phase response in the liverQ34335353
Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory SubstratesQ34400781
Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in miceQ34640445
Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomyQ34793887
New concepts in liver regenerationQ34802344
Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alphaQ34992544
NF-κB and STAT3 - key players in liver inflammation and cancerQ35347976
Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell lineQ35745911
Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3Q36446884
Redox regulation of hepatocyte apoptosisQ36849043
Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas.Q37124872
In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization.Q37257106
Glutathione in liver diseases and hepatotoxicityQ37266837
Glutathione: overview of its protective roles, measurement, and biosynthesisQ37270914
NF-kappaB signalling: embracing complexity to achieve translationQ37659380
Glutathionylation of p65NF-kappaB correlates with proliferating/apoptotic hepatoma cells exposed to pro- and anti-oxidantsQ39819533
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient miceQ41841000
Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activationQ42066524
P433issue2
P921main subjecthepatectomyQ1514021
P577publication date2013-01-01
P1433published inJournal of liver: disease & transplantationQ27724770
P1476titleSustained Glutathione Deficiency Interferes with the Liver Response to TNF-α and Liver Regeneration after Partial Hepatectomy in Mice
P478volume1

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cites work (P2860)
Q64231690Associations of Oxidative Stress and Postoperative Outcome in Liver Surgery with an Outlook to Future Potential Therapeutic Options
Q41885663Different doses of partial liver irradiation promotes hepatic regeneration in rat
Q52666865TRAP-seq identifies cystine/glutamate antiporteras a driver of recovery from liver injury.
Q58095618The Role of Adipokines in Surgical Procedures Requiring Both Liver Regeneration and Vascular Occlusion
Q36607570Tissue nonautonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila

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