Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

scientific article published on 16 December 2013

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease is …
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scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2013.11.014
P932PMC publication ID3945161
P698PubMed publication ID24355211

P50authorD Allan ButterfieldQ66912067
P2093author name stringSusan A Farr
John E Morley
M Paul Murphy
Rukhsana Sultana
Thomas L Platt
Michael L Niehoff
Vijaya Kumar
Zhaoshu Zhang
Jessica L Ripley
P2860cites workStructure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signalingQ24298930
Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubulesQ24302556
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domainQ24609907
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsQ24685475
Measurement of protein using bicinchoninic acidQ26778491
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3.Q48622377
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brainQ48822557
Delivery across the blood-brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor proteinQ48876526
Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 miceQ49096995
Beta-amyloid precursor polypeptide in SAMP8 mice affects learning and memoryQ49097021
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Age-related deterioration of ability of acquisition in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory.Q52120589
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2013 Alzheimer's disease facts and figuresQ86421768
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptidesQ28205921
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsQ28218883
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
Molecular cloning and expression of glycogen synthase kinase-3/factor AQ28569645
Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative StressQ29617845
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypesQ30530899
Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognitionQ33576221
Regulatory mechanisms of cellular response to oxidative stressQ33750101
Judging a protein by more than its name: GSK-3.Q34093128
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic miceQ34449486
Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive declineQ35840610
The many faces of tauQ35870359
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's diseaseQ36012200
Glycogen synthase kinase 3: a point of integration in Alzheimer's disease and a therapeutic target?Q36063447
Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicityQ36464631
GSK-3 is essential in the pathogenesis of Alzheimer's disease.Q36568147
The GSK3 hypothesis of Alzheimer's diseaseQ37035378
AEG-35156, an antisense oligonucleotide against X-linked inhibitor of apoptosis for the potential treatment of cancerQ37179130
From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).Q37354749
Making sense of therapeutics using antisense technologyQ38014478
Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brainQ38050263
Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.Q38318490
Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative StressQ38355236
In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases.Q39448933
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2.Q40473279
Divergent roles of GSK3 and CDK5 in APP processingQ40611214
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.Q41423732
Learning and memory in the SAMP8 mouseQ41716293
Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.Q44755335
Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brainQ44777555
Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescence-accelerated-prone 8 mice brainQ44944553
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated miceQ44985177
A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.Q45970893
Preproenkephalin targeted antisenses cross the blood-brain barrier to reduce brain methionine enkephalin levels and increase voluntary ethanol drinkingQ46757070
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changesQ48105061
Lithium protects cultured neurons against beta-amyloid-induced neurodegenerationQ48163930
Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degenerationQ48303820
Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.Q48389526
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinaseQ48406074
Lipid peroxidation in brain during aging in the senescence-accelerated mouse (SAM).Q48469494
On the delay-dependent involvement of the hippocampus in object recognition memoryQ48542116
P4510describes a project that usesImageJQ1659584
P921main subjectAlzheimer's diseaseQ11081
P304page(s)387-395
P577publication date2013-12-16
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleAntisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease
P478volume67