| P2093 | author name string | Catherine M Cowan | |
| | Amrit Mudher | |
| P2860 | cites work | Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease | Q24312611 |
| | Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262 | Q24313123 |
| | SUMO modification of Huntingtin and Huntington's disease pathology | Q24324137 |
| | Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments | Q24599152 |
| | Transmission and spreading of tauopathy in transgenic mouse brain | Q24651334 |
| | Ultrastructure and biochemical composition of paired helical filaments in corticobasal degeneration | Q24676458 |
| | Neuropathological stageing of Alzheimer-related changes | Q27860862 |
| | Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain | Q28116593 |
| | Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells | Q28118982 |
| | Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments | Q28139504 |
| | Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective | Q28185660 |
| | Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease | Q28242505 |
| | Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death | Q28287762 |
| | Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice | Q28346155 |
| | Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies | Q28576082 |
| | Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure | Q28910456 |
| | Tau suppression in a neurodegenerative mouse model improves memory function | Q29615831 |
| | Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology | Q29617284 |
| | Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease | Q29617286 |
| | Neurodegenerative tauopathies | Q29619895 |
| | Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. | Q30419801 |
| | Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy | Q30479525 |
| | Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau | Q30480843 |
| | The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity. | Q30490027 |
| | Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden | Q30497435 |
| | Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. | Q30519474 |
| | Tau filament formation in transgenic mice expressing P301L tau. | Q31442641 |
| | The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease | Q31807516 |
| | Earliest stages of tau conformational changes are related to the appearance of a sequence of specific phospho-dependent tau epitopes in Alzheimer's disease. | Q33315002 |
| | Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments | Q37238270 |
| | Tau pathophysiology in neurodegeneration: a tangled issue | Q37375331 |
| | Anti-tau oligomers passive vaccination for the treatment of Alzheimer disease | Q37803509 |
| | Granular tau oligomers as intermediates of tau filaments | Q39202279 |
| | Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease | Q39202284 |
| | Assembly of two distinct dimers and higher-order oligomers from full-length tau. | Q39420626 |
| | Preparation and Characterization of Neurotoxic Tau Oligomers | Q39636310 |
| | Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. | Q40090247 |
| | Tau aggregation and toxicity in a cell culture model of tauopathy | Q40146754 |
| | Extracellular tau is toxic to neuronal cells. | Q40242845 |
| | Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. | Q40273314 |
| | Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). | Q40372287 |
| | Hirano bodies and related neuronal inclusions | Q40765085 |
| | Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament | Q40871850 |
| | Tau protein and the neurofibrillary pathology of Alzheimer's disease | Q40983038 |
| | Image reconstruction of the Alzheimer paired helical filament | Q41433311 |
| | Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model | Q41868802 |
| | Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures | Q41940387 |
| | Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy | Q42049177 |
| | Role of glycosaminoglycans in determining the helicity of paired helical filaments | Q42049334 |
| | Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. | Q42280027 |
| | Correlations of synaptic and pathological markers with cognition of the elderly | Q42478788 |
| | Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein | Q42491661 |
| | Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein | Q42827866 |
| | Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila. | Q43195237 |
| | Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton | Q43616654 |
| | Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles | Q43642001 |
| | Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments | Q44244212 |
| | Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro | Q44429258 |
| | Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila | Q44662134 |
| | GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila | Q44782542 |
| | Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers | Q44789590 |
| | Pseudophosphorylation of tau protein alters its ability for self-aggregation. | Q44792297 |
| | Promotion of hyperphosphorylation by frontotemporal dementia tau mutations | Q44931294 |
| | Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. | Q45050796 |
| | Identification of oligomers at early stages of tau aggregation in Alzheimer's disease | Q33713341 |
| | Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo | Q33771431 |
| | Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments | Q33983175 |
| | Abnormal tau-containing filaments in neurodegenerative diseases | Q34001297 |
| | Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons | Q34340308 |
| | Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes | Q34395482 |
| | Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs | Q34462500 |
| | An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice | Q34687145 |
| | Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity | Q34695519 |
| | RNA stimulates aggregation of microtubule-associated protein tau into Alzheimer-like paired helical filaments | Q34737245 |
| | Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. | Q35067755 |
| | Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy | Q35088298 |
| | Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-beta structure | Q35171526 |
| | Are tangles as toxic as they look? | Q35214319 |
| | The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics | Q35216140 |
| | Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. | Q35574384 |
| | Truncation of tau at E391 promotes early pathologic changes in transgenic mice | Q35612217 |
| | Tau protein and neurodegeneration | Q35703317 |
| | NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy | Q35747174 |
| | Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease. | Q35764771 |
| | Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration | Q35795163 |
| | Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model | Q35840438 |
| | Tau aggregation is driven by a transition from random coil to beta sheet structure | Q35992125 |
| | Trans-cellular propagation of Tau aggregation by fibrillar species | Q36003836 |
| | Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies | Q36004991 |
| | Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases | Q36082071 |
| | Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses | Q36137237 |
| | Assembly in vitro of tau protein and its implications in Alzheimer's disease. | Q36173219 |
| | The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system | Q36295481 |
| | Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro | Q36531639 |
| | A decade of tau transgenic animal models and beyond | Q36817223 |
| | Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau. | Q36918222 |
| | Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure | Q36964038 |
| | Small-molecule mediated neuroprotection in an in situ model of tauopathy | Q37087223 |
| | Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination. | Q46213374 |
| | Triggers of full-length tau aggregation: a role for partially folded intermediates. | Q46431919 |
| | Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. | Q46522758 |
| | Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation | Q46747580 |
| | The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. | Q46804886 |
| | Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution | Q47838808 |
| | Alz-50 antibody recognizes Alzheimer-related neuronal changes | Q48090608 |
| | Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo | Q48134444 |
| | Assembly of Alzheimer-like filaments from full-length tau protein | Q48190781 |
| | Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. | Q48217044 |
| | In vitro polymerization of oxidized tau into filaments | Q48267643 |
| | Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. | Q48270156 |
| | Neurons may live for decades with neurofibrillary tangles | Q48277531 |
| | Neurofibrillary pathology of Alzheimer's disease and other tauopathies. | Q48291136 |
| | Cdk5 is a key factor in tau aggregation and tangle formation in vivo | Q48300530 |
| | Lack of the carboxyl terminal sequence of tau in ghost tangles of Alzheimer's disease | Q48345252 |
| | Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity | Q48501542 |
| | Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells | Q48503134 |
| | Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones | Q48565334 |
| | Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease | Q48820847 |
| | Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans | Q48891767 |
| | Observations on the brains of demented old people | Q48896308 |
| | Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant. | Q51019667 |
| | Tau and tau reporters disrupt central projections of sensory neurons in Drosophila. | Q52162893 |
| | Memory and mental status correlates of modified Braak staging. | Q52170951 |
| | Epitopes that span the tau molecule are shared with paired helical filaments. | Q53186865 |
| | Tau factor polymers are similar to paired helical filaments of Alzheimer's disease | Q53192990 |
| | Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. | Q53237934 |
| | Oxidative regulation of fatty acid-induced tau polymerization. | Q53239053 |
| | Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. | Q53246695 |
| | Relative roles of plaques and tangles in the dementia of Alzheimer's disease: correlations using three sets of neuropathological criteria. | Q53312706 |
| | C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. | Q53343397 |
| | Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform | Q54965151 |
| | Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias | Q60603640 |
| | Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure | Q60603641 |
| | The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy | Q60603646 |
| | Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia | Q69072601 |
| | Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease | Q70319519 |
| | In vitro conditions for the self-polymerization of the microtubule-associated protein, tau factor | Q70385720 |
| | Two actin binding proteins, actin depolymerizing factor and cofilin, are associated with Hirano bodies | Q70948371 |
| | Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction | Q71381766 |
| | Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment | Q73626089 |
| | Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations | Q74664401 |
| | Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice | Q80918689 |
| | Pathogenesis of the tauopathies | Q84590188 |
| P304 | page(s) | 114 | |
| P577 | publication date | 2013-08-13 | |
| P1433 | published in | Frontiers in Neurology | Q15817039 |
| P1476 | title | Are tau aggregates toxic or protective in tauopathies? | |
| P478 | volume | 4 | |