A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.

scientific article published on December 2010

A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANIE.201005585
P932PMC publication ID3033200
P698PubMed publication ID21105033
P5875ResearchGate publication ID49633399

P50authorMaria PellegriniQ41824510
Prisca BoisguerinQ55117843
P2093author name stringDean R Madden
Patrick R Cushing
Lars Vouilleme
P2860cites workLack of acrosome formation in mice lacking a Golgi protein, GOPC.Q24534997
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activityQ28142263
Identification of the cystic fibrosis gene: genetic analysisQ29614402
Lung infections associated with cystic fibrosisQ30080000
Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs.Q30357485
An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studiesQ31056625
Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanismsQ33304541
A specificity map for the PDZ domain familyQ33373127
Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in miceQ33409811
Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial culturesQ33728190
E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cellsQ33909378
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.Q33925348
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.Q34162541
Pharmacologic therapy for stop mutations: how much CFTR activity is enough?Q35930656
Airway surface dehydration in cystic fibrosis: pathogenesis and therapyQ36705212
Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epitheliaQ37101136
The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cellsQ39728531
Targeting CAL as a negative regulator of DeltaF508-CFTR cell-surface expression: an RNA interference and structure-based mutagenetic approachQ40198458
Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small moleculesQ40323738
Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibroQ40366116
The Cystic Fibrosis Transmembrane Conductance RegulatorQ40486029
PDZ domain interaction controls the endocytic recycling of the cystic fibrosis transmembrane conductance regulatorQ40712140
Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targetingQ40729462
Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosisQ41714520
The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recyclingQ41893473
Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blockerQ42831765
New insights into cystic fibrosis: molecular switches that regulate CFTRQ56680230
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutationQ58034953
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cellsQ72097990
Association of the cystic fibrosis transmembrane regulator with CAL: structural features and molecular dynamicsQ81582178
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)9907-9911
P577publication date2010-12-01
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleA stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR
P478volume49