The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

scientific article published on 19 September 2017

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation is …
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P356DOI10.3389/FIMMU.2017.01145
P932PMC publication ID5610720
P698PubMed publication ID28974948

P50authorBarbara UzonyiQ55427920
Mihály JózsiQ56452856
P2093author name stringAnne Kopp
Mario Hebecker
Ádám I Csincsi
Marcell Cserhalmi
Zoltán Mezei
P2860cites workStructural basis for engagement by complement factor H of C3b on a self surfaceQ24604385
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complementQ24619612
Complement factor H related proteins (CFHRs)Q26851489
Dimerization of complement factor H-related proteins modulates complement activation in vivoQ27676814
Structural basis for sialic acid-mediated self-recognition by complement factor HQ27696183
Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparinQ28141946
A new map of glycosaminoglycan and C3b binding sites on factor HQ28289935
An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)Q28293350
Comparison of surface recognition and C3b binding properties of mouse and human complement factor HQ28505240
Isolation and characterization of a novel rat factor H-related protein that is up-regulated in glomeruli under complement attackQ28567667
Binding of the long pentraxin PTX3 to factor H: interacting domains and function in the regulation of complement activationQ29147380
FHR-4A: a new factor H-related protein is encoded by the human FHR-4 gene.Q31131779
Identification and sequence analysis of four complement factor H-related transcripts in mouse liverQ33253097
Two factor H-related proteins from the mouse: expression analysis and functional characterizationQ33259755
Functional analysis in serum from atypical Hemolytic Uremic Syndrome patients reveals impaired protection of host cells associated with mutations in factor H.Q33360768
Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functionsQ33369509
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndromeQ33375219
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domainsQ33375335
The spectrum of phenotypes caused by variants in the CFH gene.Q33383766
Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndromeQ33385723
Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndromeQ33386177
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3.Q33402289
Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regionsQ33405609
Of mice and men: The factor H protein family and complement regulation.Q33421580
Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndromeQ33430961
Self-nonself discrimination by the complement systemQ33433754
Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor HQ33596128
Factor H Family Proteins in Complement Evasion of MicroorganismsQ33700779
New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseasesQ34146380
Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein.Q34416754
Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibilityQ34753608
Human factor H-related protein 2 (CFHR2) regulates complement activationQ35048080
Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injuryQ35097512
FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.Q36045917
Essential role of surface-bound complement factor H in controlling immune complex-induced arthritisQ36714001
Cloning and recombinant expression of a barred sand bass (Paralabrax nebulifer) cDNA. The encoded protein displays structural homology and immunological crossreactivity to human complement/cofactor related plasma proteins.Q36847448
C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulationQ36891110
The C-terminus of complement factor H is essential for host cell protectionQ37238656
Complement activation and inhibition: a delicate balance.Q37368654
Functional anatomy of complement factor H.Q38108831
Factor h: a complement regulator in health and disease, and a mediator of cellular interactions.Q38223669
Factor H-related proteins determine complement-activating surfacesQ38483777
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding siteQ38596477
Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in VitroQ38770928
Complement in removal of the dead - balancing inflammationQ38991044
The complement factor H-related proteinsQ38991052
Complement factor H in host defense and immune evasion.Q39036058
The baculovirus expression vector pBSV-8His directs secretion of histidine-tagged proteinsQ39154812
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b proteinQ39361819
Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cellsQ39904920
Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activationQ39980543
Factor H-related protein 5 interacts with pentraxin 3 and the extracellular matrix and modulates complement activationQ40161972
Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-SurfacesQ40775694
Complement factor H-related hybrid protein deregulates complement in dense deposit diseaseQ41826438
Factor H and factor H-related protein 1 bind to human neutrophils via complement receptor 3, mediate attachment to Candida albicans, and enhance neutrophil antimicrobial activity.Q43222930
Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H.Q43292217
Zebrafish complement factor H and its related genes: identification, evolution, and expressionQ43498612
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assemblyQ44441855
FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation.Q48113964
C4b-binding Protein and Factor H Compensate for the Loss of Membrane-bound Complement Inhibitors to Protect Apoptotic Cells against Excessive Complement AttackQ60250539
Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfacesQ79287502
Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4Q82368755
Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formationQ84071466
P304page(s)1145
P577publication date2017-09-19
P1433published inFrontiers in ImmunologyQ27723748
P1476titleThe Murine Factor H-Related Protein FHR-B Promotes Complement Activation
P478volume8