Functional differences between dimeric and octameric mitochondrial creatine kinase

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Functional differences between dimeric and octameric mitochondrial creatine kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ3080623
P932PMC publication ID1136971
P698PubMed publication ID7772050
P5875ResearchGate publication ID15427243

P2093author name stringWallimann T
Kaldis P
P2860cites workIntracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasisQ24527330
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
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In vitro complex formation between the octamer of mitochondrial creatine kinase and porinQ28287016
Location and regulation of octameric mitochondrial creatine kinase in the contact sitesQ28584153
Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolismQ35360111
Native mitochondrial creatine kinase forms octameric structures. II. Characterization of dimers and octamers by ultracentrifugation, direct mass measurements by scanning transmission electron microscopy, and image analysis of single mitochondrial crQ36437374
Structure of the mitochondrial creatine kinase octamer: high-resolution shadowing and image averaging of single molecules and formation of linear filaments under specific staining conditionsQ36529072
6 Statistical analysis of enzyme kinetic dataQ36541244
Studies of Energy Transport in Heart Cells. Mitochondrial Isoenzyme of Creatine Phosphokinase: Kinetic Properties and Regulatory Action of Mg2+ IonsQ39743053
Creatine Kinase: Structure‐Activity RelationshipsQ40148560
Expression of active octameric chicken cardiac mitochondrial creatine kinase in Escherichia coli.Q41957084
The mechanism of the reaction catalysed by adenosine triphosphate-creatine phosphotransferaseQ42026640
Inhibition of adenosine 5'-triphosphate-creatine phosphotransferase by substrate-anion complexes. Evidence for the transition-state organization of the catalytic siteQ42922275
Properties of a CH3-blocked creatine kinase with altered catalytic activity. Kinetic consequences of the presence of the blocking groupQ43473627
In situ compartmentation of creatine kinase in intact sarcomeric muscle: the acto-myosin overlap zone as a molecular sieveQ46370911
Inhibition of creatine kinase by chromium nucleotidesQ47907733
Creatine kinase of rat heart mitochondria. Coupling of creatine phosphorylation to electron transport.Q48643968
Mitochondrial creatine kinase from chicken brain. Purification, biophysical characterization, and generation of heterodimeric and heterooctameric molecules with subunits of other creatine kinase isoenzymesQ48896726
Quantitative analysis of the 'phosphocreatine shuttle': I. A probability approach to the description of phosphocreatine production in the coupled creatine kinase-ATP/ADP translocase-oxidative phosphorylation reactions in heart mitochondria.Q52393139
Creatine kinase of heart mitochondria: changes in its kinetic properties induced by coupling to oxidative phosphorylation.Q52713752
Use of pH studies to elucidate the catalytic mechanism of rabbit muscle creatine kinase.Q52739736
Mitochondrial creatine kinase mediates contact formation between mitochondrial membranes.Q54312114
Muscle-type MM creatine kinase is specifically bound to sarcoplasmic reticulum and can support Ca2+ uptake and regulate local ATP/ADP ratios.Q54327845
The N-terminal heptapeptide of mitochondrial creatine kinase is important for octamerization.Q54640863
Native mitochondrial creatine kinase forms octameric structures. I. Isolation of two interconvertible mitochondrial creatine kinase forms, dimeric and octameric mitochondrial creatine kinase: characterization, localization, and structure-function reQ67955746
Metabolite channelling in aerobic energy metabolismQ67977323
Specific enhancement of the cardiac myofibrillar ATPase by bound creatine kinaseQ68052510
Functional studies with the octameric and dimeric form of mitochondrial creatine kinase. Differential pH-dependent association of the two oligomeric forms with the inner mitochondrial membraneQ68797330
Only one of the two interconvertible forms of mitochondrial creatine kinase binds to heart mitoplastsQ69715338
Kinetic properties of the octameric and dimeric forms of mitochondrial creatine kinase and physiological role of the enzymeQ69804076
Functional coupling between sarcoplasmic-reticulum-bound creatine kinase and Ca(2+)-ATPaseQ70744219
Function of M-line-bound creatine kinase as intramyofibrillar ATP regenerator at the receiving end of the phosphorylcreatine shuttle in muscleQ72577569
Kinetics of assembly and dissociation of the mitochondrial creatine kinase octamer. A fluorescence studyQ72674811
Isotope exchange studies of the mechanism of the reaction catalyzed by adenosine triphosphate: creatine phosphotransferaseQ72772006
Creatine kinase: the reactive cysteine is required for synergism but is nonessential for catalysisQ72838514
P407language of work or nameEnglishQ1860
P304page(s)623-627
P577publication date1995-06-01
P1433published inBiochemical JournalQ864221
P1476titleFunctional differences between dimeric and octameric mitochondrial creatine kinase
P478volume308 ( Pt 2)

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cites work (P2860)
Q74532740Characterization of isoforms of human mitochondrial creatine kinase by isoelectric focusing
Q74284713Effects of free radicals on cytosolic creatine kinase activities and protection by antioxidant enzymes and sulfhydryl compounds
Q42791183Enzymatic Characteristics of Creatine Kinase System under Conditions of Cerebral Circulatory Disorders
Q57768703Fluxes through cytosolic and mitochondrial creatine kinase, measured by P-31 NMR
Q42995168Free radical-induced inactivation of creatine kinase: influence on the octameric and dimeric states of the mitochondrial enzyme (Mib-CK).
Q46982701Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle.
Q41992226Mitochondrial creatine kinase isoform expression does not correlate with its mode of action.
Q44228257Mitochondrial creatine kinase with atypical pI values detected in serum of a patient with ovarian hepatoid yolk sac tumor
Q55067977Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: implications for cellular function and mitochondrial structure.
Q27659328Structural Basis for the Mechanism and Substrate Specificity of Glycocyamine Kinase, a Phosphagen Kinase Family Member ,
Q54529039[Macro creatine kinase type 1 as a cause of increase of CF-MB isoenzyme. Apropos of 7 cases]

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