Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain

scientific article published on 8 December 2014

Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FNINS.2014.00394
P932PMC publication ID4259106
P698PubMed publication ID25538548
P5875ResearchGate publication ID270004182

P50authorShivakumar KeerthikumarQ56438535
Louie N van de LagemaatQ92084885
P2093author name stringDaniëlle G M Bosch
Bonnie Nijhof
J Alexander Heimel
Mahdokht Kohansal-Nodehi
P2860cites workExpression of GABA(B) receptors is altered in brains of subjects with autismQ37319772
Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autismQ37388568
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophreniaQ37929602
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Characterization of the proteome, diseases and evolution of the human postsynaptic density.Q42610204
Suppressed GABAergic inhibition as a common factor in suspected etiologies of autismQ43671998
Population-specific expression analysis (PSEA) reveals molecular changes in diseased brainQ43681272
Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic studyQ43868387
Downregulation of GABAA receptor protein subunits α6, β2, δ, ε, γ2, θ, and ρ2 in superior frontal cortex of subjects with autismQ44117298
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar corticesQ44174105
In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autismQ48345676
Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorderQ48563558
Glutamate receptor 6 gene (GluR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorderQ50312813
Over-inhibition: a model for developmental intellectual disabilityQ81158510
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndromeQ24530286
Functional impact of global rare copy number variation in autism spectrum disordersQ24596191
Patterns and rates of exonic de novo mutations in autism spectrum disordersQ28264242
Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmissionQ28507507
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutationsQ29030218
De novo mutations revealed by whole-exome sequencing are strongly associated with autismQ29547269
Model of autism: increased ratio of excitation/inhibition in key neural systemsQ29547530
Transcriptomic analysis of autistic brain reveals convergent molecular pathologyQ29614877
Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010Q29615713
Brain plasticity and disease: a matter of inhibitionQ30474810
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.Q33398247
Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autismQ34071796
Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature agesQ34211584
Increased serum levels of glutamate in adult patients with autism.Q34550517
In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autismQ34777549
Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects.Q36025486
A discovery resource of rare copy number variations in individuals with autism spectrum disorderQ36451331
Linkage and association of the glutamate receptor 6 gene with autismQ36900622
Reduced subcortical glutamate/glutamine in adults with autism spectrum disorders: a [¹H]MRS study.Q37065273
GABA(A) receptor downregulation in brains of subjects with autismQ37229115
P921main subjectautismQ38404
P304page(s)394
P577publication date2014-12-08
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleAge-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain
P478volume8

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cites work (P2860)
Q28069757Advancing the understanding of autism disease mechanisms through genetics
Q30926716Collaborative mining of public data resources in neuroinformatics
Q35919652Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex
Q41271386Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism
Q36598019Neuroligin-2 and the tightrope of excitation/inhibition balance in the prefrontal cortex
Q48169775Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons
Q64246874Prenatal Nutritional Intervention Reduces Autistic-Like Behavior Rates Among -Deficient Mice
Q88283327Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1
Q57610553Transcriptomic Evidence for Alterations in Astrocytes and Parvalbumin Interneurons in Subjects With Bipolar Disorder and Schizophrenia

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