Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants

scientific article published on 7 November 2013

Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...877407J
P356DOI10.1371/JOURNAL.PONE.0077407
P932PMC publication ID3820691
P698PubMed publication ID24244276
P5875ResearchGate publication ID258639101

P2093author name stringAnders Bergh
Anders Widmark
Elin Thysell
Pernilla Wikström
Sead Crnalic
Emma Jernberg
Erik Bovinder Ylitalo
Stina Rudolfsson
P2860cites workImmunohistochemical localization of steroid 5 alpha-reductase 2 in the human male fetal reproductive tract and adult prostateQ42513600
Predicting survival for surgery of metastatic spinal cord compression in prostate cancer: a new scoreQ43853936
Steroid 5alpha-reductase isozymes I and II in recurrent prostate cancerQ46549099
Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent diseaseQ46716649
Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 casesQ48592065
Androgen-Independent Prostate Cancer Is a Heterogeneous Group of DiseasesQ57693579
Expression and regulation of steroid 5 alpha-reductase 2 in prostate diseaseQ71629976
Mutant androgen receptors in prostatic tumors distinguish between amino-acid-sequence requirements for transactivation and ligand bindingQ71820064
Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patientsQ84677595
Intraprostatic Steroidogenic Enzymes – LetterQ85184048
Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survivalQ21091046
Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptorQ24679336
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growthQ28116222
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancerQ30485336
Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantQ30495758
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancerQ33235187
Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancerQ34204078
Steroid hormone transforming aldo-keto reductases and cancerQ34571239
Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.Q34618859
Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancerQ34786897
Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistanceQ35083279
Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in boneQ35808422
Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signalQ36003940
Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer.Q36585622
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growthQ36876865
Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumorsQ36937170
Blockade of testicular and adrenal androgens in prostate cancer treatmentQ37829637
A new trick of an old molecule: androgen receptor splice variants taking the stage?!Q37900501
Androgen receptor rediscovered: the new biology and targeting the androgen receptor therapeuticallyQ37921011
Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer.Q39254330
The androgen axis in recurrent prostate cancerQ39675435
Evidence of limited contributions for intratumoral steroidogenesis in prostate cancerQ39750288
Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterolQ39941487
Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancerQ39954334
The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptorQ40595377
Outcome after surgery for metastatic spinal cord compression in 54 patients with prostate cancerQ41084688
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)e77407
P577publication date2013-11-07
P1433published inPLOS OneQ564954
P1476titleCharacterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants
P478volume8