Trp42 rotamers report reduced flexibility when the inhibitor acetyl-pepstatin is bound to HIV-1 protease

scientific article published on November 2000

Trp42 rotamers report reduced flexibility when the inhibitor acetyl-pepstatin is bound to HIV-1 protease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1110/PS.9.11.2232
P932PMC publication ID2144495
P698PubMed publication ID11152134
P5875ResearchGate publication ID227527143

P2093author name stringUllrich B
Polgár L
Szeltner Z
Fidy J
Laberge M
Tölgyesi F
P2860cites workExperimentally verifying molecular dynamics simulations through fluorescence anisotropy measurementsQ68189233
Confirmation that multiexponential fluorescence decay behavior of holoazurin originates from conformational heterogeneityQ69215504
Molecular dynamics simulation of HIV-1 protease in a crystalline environment and in solutionQ70556978
Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ionQ70598973
Conformational stability and catalytic activity of HIV-1 protease are both enhanced at high salt concentrationQ71058497
Unfolding pathway of apomyoglobin. Simultaneous characterization of acidic conformational states by frequency domain fluorometryQ72109482
A fluorescence study of tryptophan-histidine interactions in the peptide anantin and in solutionQ72156376
Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP releaseQ73141706
Time-resolved fluorescence anisotropy of HIV-1 protease inhibitor complexes correlates with inhibitory activityQ74252390
Studies of the fluorescence from tryptophan in melittinQ93659185
Active human immunodeficiency virus protease is required for viral infectivityQ24647696
Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin AQ24649411
X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulationsQ27639832
Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolutionQ27675151
Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 proteaseQ27696384
Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1Q27702268
X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymesQ27703747
Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 proteaseQ27748879
The interpretation of protein structures: Estimation of static accessibilityQ27860750
The Protein Data Bank: a computer-based archival file for macromolecular structuresQ27860989
A step toward the prediction of the fluorescence lifetimes of tryptophan residues in proteins based on structural and spectral data.Q30326440
Quenching-resolved emission anisotropy studies with single and multitryptophan-containing proteinsQ30447215
Thermodynamic linkage between the binding of protons and inhibitors to HIV-1 proteaseQ30480872
Inhibitors of HIV-1 protease: a major success of structure-assisted drug designQ32059371
Probing alpha-helical secondary structure at a specific site in model peptides via restriction of tryptophan side-chain rotamer conformationQ34115328
Mapping hydration water molecules in the HIV-1 protease/DMP323 complex in solution by NMR spectroscopy.Q36823608
Fluorescence quenching studies with proteinsQ40319392
Structure-based inhibitors of HIV-1 proteaseQ40835286
1La and 1Lb transitions of tryptophan: applications of theory and experimental observations to fluorescence of proteinsQ41487320
HIV-protease inhibitorsQ41751665
Tryptophan dynamics of the FK506 binding protein: time-resolved fluorescence and simulationsQ42184486
Secondary structure and signal assignments of human-immunodeficiency-virus-1 protease complexed to a novel, structure-based inhibitorQ42612484
Solution NMR evidence that the HIV-1 protease catalytic aspartyl groups have different ionization states in the complex formed with the asymmetric drug KNI-272.Q43452863
Resolution of the fluorescence excitation spectrum of indole into the 1La and 1Lb excitation bandsQ43613421
Determination of kinetic rate constants for the binding of inhibitors to HIV-1 protease and for the association and dissociation of active homodimerQ44660459
Flexibility and function in HIV-1 proteaseQ44801403
Substrate-dependent mechanisms in the catalysis of human immunodeficiency virus proteaseQ45780866
Effect of pH and nonphysiological salt concentrations on human immunodeficiency virus-1 protease dimerizationQ45784308
Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutionsQ46436480
Microperoxidase-11: molecular dynamics and Q-band excited resonance Raman of the oxidized, reduced and carbonyl forms.Q47821451
Toward understanding tryptophan fluorescence in proteinsQ47839130
Time resolved fluorescence and phosphorescence properties of the individual tryptophan residues of barnase: evidence for protein-protein interactions.Q50518253
Electrostatic effects in proteins: comparison of dielectric and charge modelsQ52422371
Flap opening in HIV-1 protease simulated by 'activated' molecular dynamics.Q53849991
Backbone dynamics of Tet repressor alpha8intersectionalpha9 loop.Q54060204
The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties.Q54197412
Quenching of tryptophan fluorescence by the active-site disulfide bridge in the DsbA protein from Escherichia coli.Q54565539
Correlation of tryptophan fluorescence intensity decay parameters with proton NMR-determined rotamer conformations: [tryptophan2]oxytocinQ67748090
P433issue11
P921main subjectrotamerQ67936600
P304page(s)2232-2245
P577publication date2000-11-01
P1433published inProtein ScienceQ7251445
P1476titleTrp42 rotamers report reduced flexibility when the inhibitor acetyl-pepstatin is bound to HIV-1 protease
P478volume9

Reverse relations

cites work (P2860)
Q33968760Co-lethality studied as an asset against viral drug escape: the HIV protease case
Q42952886Insights into Intramolecular Trp and His Side‐Chain Orientation and Stereospecific π Interactions Surrounding Metal Centers: An Investigation Using Protein Metal‐Site Mimicry in Solution
Q44535556Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH.
Q34403331The analysis of time resolved protein fluorescence in multi-tryptophan proteins

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