Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model

scientific article published on 27 October 2013

Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1003586492
P356DOI10.1186/1750-1326-8-42
P932PMC publication ID3816305
P698PubMed publication ID24160175
P5875ResearchGate publication ID258101023

P50authorLisa M EllerbyQ91624962
P2093author name stringCathy Vitelli
Theodora Papanikolaou
Mahru C An
Carlotta E Duncan
Caitlin Rugani
P2860cites workCloning of the SCA7 gene reveals a highly unstable CAG repeat expansionQ24310393
Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptorsQ24316293
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexesQ24338317
Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3Q24599788
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic miceQ24656405
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7Q28189688
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor proteinQ28216526
Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivoQ28483335
Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington's DiseaseQ28486205
Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3betaQ28565080
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylationQ28566835
The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3Q28609763
Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's diseaseQ28732195
Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse modelQ28743986
Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disordersQ30433574
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degenerationQ33854083
Histone deacetylase inhibitors reduce polyglutamine toxicityQ33953013
Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencingQ34019122
HDAC3 is a critical negative regulator of long-term memory formationQ34158695
Histone deacetylase complexes promote trinucleotide repeat expansionsQ34169694
Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's diseaseQ34358457
Excessive HDAC activation is critical for neurodegeneration in the rd1 mouse.Q34545446
Regulation of histone deacetylase activitiesQ34550653
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's diseaseQ34763178
The histone deacetylase-3 complex contains nuclear receptor corepressorsQ35155073
Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophyQ35565116
Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and deathQ36318929
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brainQ36321289
Histone deacetylase inhibitors as therapeutics for polyglutamine disordersQ36599926
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage controlQ36639688
Histone deacetylases: focus on the nervous systemQ36832256
Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicityQ37020186
HDAC inhibitors and neurodegeneration: at the edge between protection and damageQ37685428
Molecular and clinical correlations in autosomal dominant cerebellar ataxia with progressive macular dystrophy (SCA7).Q38963048
Distribution of histone deacetylases 1-11 in the rat brainQ40225359
Spinocerebellar ataxia type 7 cerebellar disease requires the coordinated action of mutant ataxin-7 in neurons and glia, and displays non-cell-autonomous bergmann glia degeneration.Q40329109
A role for both wild-type and expanded ataxin-7 in transcriptional regulationQ42479386
Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragmentQ42719817
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.Q43258139
Ataxin-7 expression analysis in controls and spinocerebellar ataxia type 7 patientsQ43609121
Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity.Q45300254
Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansionQ48039672
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transportQ48435478
Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusionsQ48464946
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes.Q52677435
SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell typesQ57387383
Distribution of ataxin-7 in normal human brain and retinaQ57969436
An expanded CAG repeat sequence in spinocerebellar ataxia type 7Q57970953
Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulationQ60623894
P4510describes a project that usesImageQuantQ112270642
P921main subjectspinocerebellar ataxia type 7Q22443706
P304page(s)42
P577publication date2013-10-27
P1433published inMolecular NeurodegenerationQ15817329
P1476titleHistone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
P478volume8

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cites work (P2860)
Q49884282Complex neuroprotective and neurotoxic effects of histone deacetylases.
Q35403365Differential effect of HDAC3 on cytoplasmic and nuclear huntingtin aggregates.
Q34309571Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury
Q38215303Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors
Q26764958Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease
Q33879684Pulling complexes out of complex diseases: Spinocerebellar Ataxia 7.
Q37445508Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells
Q57072576Roles of Post-translational Modifications in Spinocerebellar Ataxias
Q50050224Targeting HDAC3 Activity with RGFP966 Protects Against Retinal Ganglion Cell Nuclear Atrophy and Apoptosis After Optic Nerve Injury
Q33784471The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1
Q99587952Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

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