Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea

scientific article published on 8 May 2017

Complement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea is …
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scholarly articleQ13442814

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P356DOI10.1093/CKJ/SFX081
P932PMC publication ID5622895
P698PubMed publication ID28980670

P2093author name stringDavid Kavanagh
Vicky Brocklebank
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A clinicopathologic study of thrombotic microangiopathy in IgA nephropathyQ33397974
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Complement activation in thrombotic thrombocytopenic purpuraQ33399954
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Two patients with history of STEC-HUS, posttransplant recurrence and complement gene mutationsQ33408171
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Use of eculizumab in crescentic IgA nephropathy: proof of principle and conundrum?Q43241467
Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritisQ43783224
Cellular injury associated with renal thrombotic microangiopathy in human immunodeficiency virus-infected macaques.Q43862964
Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies.Q43984230
Molecular basis for high renal cell sensitivity to the cytotoxic effects of shigatoxin-1: upregulation of globotriaosylceramide expressionQ44111638
Meningococcal sepsis complicating eculizumab treatment despite prior vaccinationQ44204666
Use of eculizumab in refractory gemcitabine-induced thrombotic microangiopathyQ44441605
Outcome of Plasma Exchange Therapy in Thrombotic Microangiopathy After Renal TransplantationQ44596912
Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuriaQ44755395
Microangiopathic hemolysis and renal failure in malignant hypertensionQ45185684
Anti-C5 as prophylactic therapy in atypical hemolytic uremic syndrome in living-related kidney transplantationQ45355324
Plasmapheresis-resistant acute humoral rejection successfully treated with anti-C5 antibodyQ45736192
Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpuraQ45741802
Successful use of eculizumab in a patient with post-transplant thrombotic microangiopathy.Q45932533
Eculizumab for the treatment of preeclampsia/HELLP syndromeQ46321630
Successful treatment of the postpartum atypical hemolytic uremic syndrome with eculizumabQ46336851
Thrombotic microangiopathy as a complication in a patient with focal segmental glomerulosclerosisQ46991150
Hemolytic Uremic Syndrome in Pregnancy and PostpartumQ47736433
Severe hypertension with renal thrombotic microangiopathy: what happened to the usual suspect?Q49095351
The genetics of the alternative pathway of complement in the pathogenesis of HELLP syndrome.Q49177600
Eculizumab Induces Sustained Remission in a Patient With Refractory Primary Catastrophic Antiphospholipid SyndromeQ50172456
Factor H autoantibodies in membranoproliferative glomerulonephritis.Q50508495
Complement factor H mutations are present in ADAMTS13-deficient, ticlopidine-associated thrombotic microangiopathies.Q51006144
Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndromeQ33430035
Direct evidence of complement activation in HELLP syndrome: A link to atypical hemolytic uremic syndromeQ33430320
Two cases of kidney transplantation-associated thrombotic microangiopathy successfully treated with eculizumabQ33430681
Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label TrialQ33431023
Carfilzomib: A cause of drug associated thrombotic microangiopathyQ33431057
Clopidogrel-induced Thrombotic Microangiopathy in a Patient with HypocomplementemiaQ33431567
New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathyQ33432069
Pregnancy-related thrombotic microangiopathies: Clues from complement biologyQ33432072
The alternative pathway of complement and the thrombotic microangiopathiesQ33432099
Proteasome inhibitor associated thrombotic microangiopathyQ33432949
Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injuryQ33433630
Renal Thrombotic Microangiopathy in Proliferative Lupus Nephritis: Risk Factors and Clinical Outcomes: A Case-Control StudyQ33434207
Use of Eculizumab in Atypical Hemolytic Uremic Syndrome, Complicating Systemic Lupus ErythematosusQ33434807
Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpuraQ33435545
Atypical Hemolytic Uremic Syndrome Secondary to Lupus Nephritis, Responsive to EculizumabQ33436295
Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal DiseaseQ33437631
Micro-angiopathic haemolysis, thrombocytopenia and nephrotic syndrome associated with membranous nephropathy in a Vietnamese boy.Q33448753
Partial H (beta 1H) deficiency and glomerulonephritis in two familiesQ33478578
Development of focal segmental sclerosis and hyalinosis in hemolytic uremic syndromeQ33498047
Genetic studies into inherited and sporadic hemolytic uremic syndromeQ33502189
Antineutrophilic cytoplasmic antibody-associated vasculitis with hypocomplementemia has a higher incidence of serious organ damage and a poor prognosisQ33595396
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndromeQ33630007
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibilityQ33921170
Complement factor H autoantibodies are associated with early stage NSCLC.Q33937882
Renal involvement in primary antiphospholipid syndrome: retrospective analysis of 160 patientsQ33944778
Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodiesQ34080920
Genome-wide association study identifies susceptibility loci for IgA nephropathyQ34170453
Long-term renal outcome in patients with malignant hypertension: a retrospective cohort study.Q34356666
Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese populationQ34359378
Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.Q34427591
Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient miceQ34537391
Eculizumab (Alexion).Q34788815
The local complement activation on vascular bed of patients with systemic sclerosis: a hypothesis-generating studyQ35057817
P433issue5
P304page(s)600-624
P577publication date2017-05-08
P1433published inClinical kidney journal / an academic journal of the ERA-EDTA (European Renal Association - European Dialysis and Transplant Association)Q26842221
P1476titleComplement C5-inhibiting therapy for the thrombotic microangiopathies: accumulating evidence, but not a panacea
P478volume10

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cites work (P2860)
Q54262493A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study.
Q96304889An update on the management of antiphospholipid syndrome
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Q92675561Dengue virus and the complement alternative pathway
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Q58788522TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease
Q64993828Targeting properdin in the treatment of atypical haemolytic uraemic syndrome: better than eculizumab?
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Q61799225The new , 4 years later
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Q52728783What is the evidence for the role of therapeutic apheresis in the management of complement-associated thrombotic microangiopathies?

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