PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth

scientific article published on 11 February 2012

PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PROSTAGLANDINS.2012.02.001
P932PMC publication ID3312001
P698PubMed publication ID22342504
P5875ResearchGate publication ID221840070

P2093author name stringBeverly H Koller
Artiom Gruzdev
Martina Kovarova
MyTrang Nguyen
P2860cites workMutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosusQ24302408
Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicityQ24324102
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenaseQ24563699
Bves: ten years afterQ24596726
Type VIII collagen stimulates smooth muscle cell migration and matrix metalloproteinase synthesis after arterial injuryQ24669720
BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiationQ24679290
Genetic and pharmacological analysis of prostanoid receptor functionQ28186062
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regenerationQ28238880
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathyQ28281228
Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in miceQ28506846
Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosusQ28512617
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressureQ28585606
Smooth-muscle contraction without smooth-muscle myosinQ28586097
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesisQ29616631
Determination and comparison of specific activity of the HIF-prolyl hydroxylasesQ33292362
Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironmentsQ33300355
Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient miceQ33720481
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptorQ33852848
Molecular mechanism of cGMP-mediated smooth muscle relaxationQ33980649
Mouse Pop1 is required for muscle regeneration in adult skeletal muscleQ34302313
In vivo retroviral gene transfer into human bronchial epithelia of xenograftsQ35614313
Hyaluronic acid accumulation and endothelial cell detachment in intimal thickening of the vessel wall. The normal and genetically defective ductus arteriosusQ35818978
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrowQ36369274
Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channelQ37360962
Medical manipulation of the ductus arteriosusQ39313175
Ontogeny of the ductus arteriosus response to prostaglandins and inhibitors of their synthesis.Q40283665
Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugsQ41441085
The pharmacology of the ductus arteriosusQ41741798
Role of nitric oxide and cGMP system in regulation of ductus arteriosus tone in ovine fetusQ42528803
Effects of the prostanoids on the proliferation or hypertrophy of cultured murine aortic smooth muscle cellsQ43263758
Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinasesQ44302127
Receptors and pathways mediating the effects of prostaglandin E2 on airway toneQ44346690
Vascular endothelial growth factor induction by prostaglandin E2 in human airway smooth muscle cells is mediated by E prostanoid EP2/EP4 receptors and SP-1 transcription factor binding sites.Q46560423
Regulation of ductus arteriosus patency by nitric oxide in fetal lambs: the role of gestation, oxygen tension, and vasa vasorumQ46578807
Occurrence of endothelium-derived relaxing factor--nitric oxide in the lamb ductus arteriosus.Q50776608
Bves: prototype of a new class of cell adhesion molecules expressed during coronary artery development.Q52131402
The response of the ductus arteriosus to prostaglandins.Q53729775
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.Q53963048
Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migrationQ67680428
Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesisQ67780371
Widespread recombinase expression using FLPeR (flipper) miceQ73266365
EGF family ligand-dependent phenotypic modulation of smooth muscle cells through EGF receptorQ73445622
Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid jointQ73521731
Nitric oxide mediates LC-3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formationQ78069433
Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2Q78701428
Gremlin promotes vascular smooth muscle cell proliferation and migrationQ80216002
Prostaglandin E2 induces vascular relaxation by E-prostanoid 4 receptor-mediated activation of endothelial nitric oxide synthaseQ80627964
P433issue3-4
P304page(s)109-119
P577publication date2012-02-11
P1433published inProstaglandins and Other Lipid MediatorsQ15754476
P1476titlePGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth
P478volume97

Reverse relations

cites work (P2860)
Q64241863Complex Role for E-Prostanoid 4 Receptors in Hypertension
Q34448421Cyclooxygenase-2-derived prostaglandin E₂ promotes injury-induced vascular neointimal hyperplasia through the E-prostanoid 3 receptor.
Q36322633Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression
Q37403765Identification of differentially regulated genes in human patent ductus arteriosus
Q36811256Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE
Q62058455Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins
Q42356975Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero
Q59173748Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing
Q33840349Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone.