The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes

scientific article published on September 1981

The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ1980551
P932PMC publication ID1163301
P698PubMed publication ID7326022
P5875ResearchGate publication ID15873123

P50authorAndrew P HalestrapQ38321371
P2093author name stringThomas AP
P2860cites workControl of gluconeogenesis and of enzymes of glycogen metabolism in isolated rat hepatocytes. A parallel study of the effect of phenylephrine and of glucagonQ28328548
The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitorsQ28339341
Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of ratsQ28568430
Regulation of hepatic fatty acid oxidation and ketone body productionQ34248852
Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.Q38362681
Studies on the alpha-andrenergic activation of hepatic glucose output. II. Investigation of the roles of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in the actions of phenylephrine in isolated hepatocytesQ39108490
Hormonal regulation of liver mitochondrial pyruvate carrier in relation to gluconeogenesis and lipogenesisQ39121992
Studies on alpha-adrenergic activation of hepatic glucose outputQ39204899
Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrierQ39207007
Stimulation of pyruvate transport in metabolizing mitochondria through changes in the transmembrane pH gradient induced by glucagon treatment of ratsQ39207012
Regulation of mitochondrial pyruvate carboxylation and gluconeogenesis in rat hepatocytes via an alpha-adrenergic, adenosine 3‘:5‘-monophosphate-independent mechanismQ39233941
Mechanism of the stimulation of serine and alanine transport into isolated rat liver cells by bicarbonate ionsQ39291536
Regulation of pyruvate metabolism in mammalian tissuesQ39843260
The hormonal control of gluconeogenesis by regulation of mitochondrial pyruvate carboxylation in isolated rat liver cellsQ39924523
Cyclic AMP induced inhibition of pyruvate kinase flux in the intact liver cellQ39931523
The stimulatory effect of glucagon and dibutyryl cyclic AMP on ureogenesis and gluconeogenesis in relation to the mitochondrial ATP contnetQ40090915
Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactateQ40104055
Acute hormonal control of pyruvate kinase and lactate formation in the isolated rat hepatocyteQ40181864
The Stimulation of the Mitochondrial Uncoupler-Dependent ATPase in Isolated Hepatocytes by Catecholamines and Glucagon and Its Relationship to GluconeogenesisQ40280266
Mitochondrial pyruvate transport and its hormonal regulationQ40281334
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural studyQ41115222
Rate-limiting steps in metabolic pathwaysQ41451522
Gluconeogenesis in the kidney cortex. Effects of d-malate and amino-oxyacetateQ41522089
Adrenergic control of glycolysis and pyruvate kinase activity in hepatocytes from young and old ratsQ41739471
The mechanism of the inhibition of the mitochondrial pyruvate transportater by alpha-cyanocinnamate derivativesQ41861312
The effect of lysine on gluconeogenesis from lactate in rat hepatocytesQ41864408
The effects of pyruvate concentration, dichloroacetate and alpha-cyano-4-hydroxycinnamate on gluconeogenesis, ketogenesis and [3-hydroxybutyrate]/[3-oxobutyrate] ratios in isolated rat hepatocytesQ41930443
Acute regulation of pyruvate kinase activity in rat epididymal adipose tissue by insulinQ42259465
Permeability of the liver cell membrane to quinolinateQ42546107
The specificity and metabolic implications of the inhibition of pyruvate transport in isolated mitochondria and intact tissue preparations by alpha-Cyano-4-hydroxycinnamate and related compoundsQ42554050
Carbohydrate metabolism of the perfused rat liverQ42952408
Alanine metabolism in rat liver mitochondriaQ43456331
The Pathway of Gluconeogenesis in the Cortex of Guinea-Pig Kidney. Use of Aminooxyacetate as a Transaminase InhibitorQ44214161
Characterization of oxalate as a catabolite of dichloroacetate responsible for the inhibition of gluconeogenesis and pyruvate carboxylation in rat liver cellsQ51663632
Studies on the Mechanism of Action of Glucagon on GluconeogenesisQ51677728
Control of gluconeogenesis in liver. 3. Effects of L-lactate, pyruvate, fructose, glucagon, epinephrine, and adenosine 3',5'-monophosphate on gluconeogenic intermediates in the perfused rat liver.Q51686629
Use of the liquid scintillation spectrometer for determining adenosine triphosphate by the luciferase enzyme.Q52472890
Comparison of effects of glucagon and valinomycin on rat liver mitochondria and cells.Q53739944
The involvement of mitochondrial pyruvate transport in the pathways of gluconeogenesis from serine and alanine in isolated rat and mouse liver cellsQ66944096
Pyruvate and acetoacetate transport in mitochondria. A reappraisalQ67276537
Metabolic implications of the distribution of the alanine aminotransferase isoenzymesQ67315431
Glucagon treatment stimulates the metabolism of hepatic submitochondrial particlesQ67327925
The mitochondrial pyruvate carrier, its exchange properties and its regulation by glucagonQ67444226
The mechanism of the stimulation of pyruvate transport into rat liver mitochondria by glucagonQ67654453
Studies on the regulation of gluconeogenesis in isolated rat liver cells by epinephrine and glucagonQ68678479
Mechanism of Action of the Hypoglycemic Agent DiphenyleneiodoniumQ69564158
The mechanism of inhibition of phosphoenolpyruvate carboxylase by quinolinic acidQ70470848
Effects of ethyl hydrazinoacetate on gluconeogenesis and on ethanol oxidation in rat hepatocytesQ71139033
Control of hepatic mitochondrial CO2 fixation by glucagon, epinephrine, and cortisolQ71246306
Antagonistic effect of insulin on glucagon-evoked hyperpolarization. A correlation between changes in membrane potential and gluconeogenesisQ72127032
Removal of fatty acids from serum albumin by charcoal treatmentQ72200044
Epinephrine-stimulated phosphorylation of pyruvate kinase in hepatocytesQ72861060
The role of phosphorylation in the α-adrenergic-mediated inhibition of rat hepatic pyruvate kinaseQ72864737
Kinetic studies of rat liver glutamicalanine transaminaseQ79554760
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectgluconeogenesisQ191835
glucagonQ28163629
P304page(s)551-560
P577publication date1981-09-01
P1433published inBiochemical JournalQ864221
P1476titleThe rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from L-lactate in isolated rat hepatocytes
P478volume198

Reverse relations

cites work (P2860)
Q40146014Bioenergetics in aging
Q39661749Control of electron flux through the respiratory chain in mitochondria and cells
Q36974638Control of oxidative phosphorylation in mitochondria, cells and tissues
Q33808884Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets.
Q36583178Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.
Q72559361Hormonal regulation of mitochondrial function. Description of a system capable of mimicking several effects of glucagon
Q88574458Including the mitochondrial metabolism of L-lactate in cancer metabolic reprogramming
Q38837452Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling
Q42492344Loss of fatty acid control of gluconeogenesis and PDH complex flux in adrenalectomized rats
Q40097134Mechanisms of regulation of the partition of fatty acids between oxidation and esterification in the liver
Q92888639Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
Q28512730Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion
Q51592718Mitochondrial pyruvate metabolism in liver and kidney during acidosis.
Q28085025Mitochondrial pyruvate transport: a historical perspective and future research directions
Q42151935Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial l-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators
Q36746415The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters.
Q70197605The effect of hormones on proton compartmentation in hepatocytes
Q44660104The malate/aspartate shuttle and pyruvate kinase as targets involved in the stimulation of gluconeogenesis by phenylephrine
Q38608271The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism

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