SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection

scientific article published on 7 June 2013

SARM is required for neuronal injury and cytokine production in response to central nervous system viral infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1300374
P932PMC publication ID3710687
P698PubMed publication ID23749635

P50authorCarl F. NathanQ1037710
Adolfo García-SastreQ4684232
Melissa B. UccelliniQ55381291
P2093author name stringBobby Thomas
Rebecca Banerjee
Aihao Ding
Ying-Ju Hou
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Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptorsQ71749707
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TNF-α potentiates glutamate-induced spinal cord motoneuron death via NF-κBQ85045795
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The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus PathogenesisQ27489537
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survivalQ28512388
Glial activation involvement in neuronal death by Japanese encephalitis virus infectionQ28578439
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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitisQ29615108
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A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.Q33763795
The myeloid cells of the central nervous system parenchymaQ34024675
Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNSQ34117786
The relationship of body size, nerve cell size, axon length, and glial density in the cerebellumQ34383807
Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expressionQ34503290
Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolismQ34612473
Inflammation in neurodegenerative disease--a double-edged swordQ34775762
An inflammatory review of Parkinson's disease.Q35046915
TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNSQ35168231
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission.Q35708750
T-cell death following immune activation is mediated by mitochondria-localized SARM.Q36603131
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal deathQ36664718
Astrocytes play a key role in activation of microglia by persistent Borna disease virus infectionQ36986897
Regulation of innate immune responses in the brainQ37492253
dSarm/Sarm1 is required for activation of an injury-induced axon death pathwayQ37579571
The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief reviewQ37820180
Gene expression contributing to recruitment of circulating cells in response to vesicular stomatitis virus infection of the CNS.Q41919786
Glutamate released by Japanese encephalitis virus-infected microglia involves TNF-α signaling and contributes to neuronal deathQ43047858
Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.Q43715908
Vesicular stomatitis virus infects resident cells of the central nervous system and induces replication-dependent inflammatory responsesQ45378464
Local type I IFN receptor signaling protects against virus spread within the central nervous systemQ45386700
Distribution of vesicular stomatitis virus proteins in the brains of BALB/c mice following intranasal inoculation: an immunohistochemical analysisQ45778668
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.Q47069444
A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegansQ48860003
Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degenerationQ49084991
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalingQ50335839
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.Q50515193
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)875-883
P577publication date2013-06-07
P1433published inJournal of ImmunologyQ3521441
P1476titleSARM is required for neuronal injury and cytokine production in response to central nervous system viral infection
P478volume191

Reverse relations

cites work (P2860)
Q46491271Avian axons undergo Wallerian degeneration after injury and stress.
Q38565556Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development
Q38208077Diverse cellular and molecular modes of axon degeneration
Q38761111FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN.
Q35443253Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech
Q59126609Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines
Q41050313Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway
Q90003721Pathological modeling of TBEV infection reveals differential innate immune responses in human neurons and astrocytes that correlate with their susceptibility to infection
Q90171578Programmed axon degeneration: from mouse to mechanism to medicine
Q35677531Recoding of the vesicular stomatitis virus L gene by computer-aided design provides a live, attenuated vaccine candidate
Q40553380Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis
Q33613014SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter
Q92177173SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease
Q60045644Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity
Q46376009The axon degeneration gene SARM1 is evolutionarily distinct from other TIR domain-containing proteins
Q34907662The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling

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