New role for leucyl aminopeptidase in glutathione turnover.

scientific article published on February 2004

New role for leucyl aminopeptidase in glutathione turnover. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/BJ20031336
P932PMC publication ID1223929
P698PubMed publication ID14583094

P50authorChiara D'AmbrosioQ50488362
Andrea ScaloniQ48766205
P2093author name stringPietro Amodeo
Paolo Pelosi
Mario Cappiello
Umberto Mura
Antonella Del Corso
Alessandra Lazzarotti
Blanca L Méndez
Francesca Buono
P2860cites workRedox state of glutathione in human plasma.Q52080982
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The cell-specific anti-proliferative effect of reduced glutathione is mediated by gamma-glutamyl transpeptidase-dependent extracellular pro-oxidant reactions.Q53801203
Minor Thiols Cysteine and Cysteinylglycine Regulate the Competition between Glutathione and Protein SH Groups in Human Platelets Subjected to Oxidative StressQ62066177
Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesisQ67315161
The primary structure of leucine aminopeptidase from bovine eye lensQ70373360
Sulfhydryl content of bovine eye lens leucine aminopeptidase. Determination of the reactivity of the sulfhydryl groups of the zinc metalloenzyme, of the enzyme activated by Mg2+, Mn2+, and Co2+, and of the metal-free apoenzymeQ70373362
Zinc binding in proteins and solution: a simple but accurate nonbonded representationQ70830917
The role of chelators in the catalysis of glutathione-gamma-glutamyl transpeptidase-dependent lipid peroxidation by transition metalsQ71956236
Glutathione metabolism by gamma-glutamyltranspeptidase leads to lipid peroxidation: characterization of the system and relevance to hepatocarcinogenesisQ72211020
Brush border membrane hydrolysis of S-benzyl-cysteine-p-nitroanilide, an activity of aminopeptidase MQ72438846
Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of gamma-glutamyl transpeptidase-dependent H2O2 production and S-thiolationQ73000461
Promotion of glutathione-gamma-glutamyl transpeptidase-dependent lipid peroxidation by copper and ceruloplasmin: the requirement for iron and the effects of antioxidants and antioxidant enzymesQ73039479
Purification and properties of an aminopeptidase from kidney cellular particulatesQ73182181
gamma-Glutamyl transpeptidase-dependent lipid peroxidation in isolated hepatocytes and HepG2 hepatoma cellsQ73268918
Chromatographic purification of cysteinyl-glycinaseQ74520609
Peptidases and alkaline phosphatases of swine kidneyQ74655461
Metabolism of glutathione. III. Enzymatic hydrolysis of cysteinylglycineQ75602807
Gamma-glutamyl transpeptidase-dependent iron reduction and LDL oxidation--a potential mechanism in atherosclerosisQ77307933
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A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidaseQ24674598
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Two-metal ion mechanism of bovine lens leucine aminopeptidase: active site solvent structure and binding mode of L-leucinal, a gem-diolate transition state analogue, by X-ray crystallographyQ27729720
Transition state analogue L-leucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65 A resolution in a new crystal formQ27729779
MOLMOL: a program for display and analysis of macromolecular structuresQ27860873
Aminopeptidases: structure and functionQ28266592
Silver staining of proteins in polyacrylamide gelsQ29616239
Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzymeQ33924313
gamma-Glutamyl transpeptidase from kidneyQ34558512
Rapid purification of rat kidney brush borders enriched in γ-glutamyl transpeptidaseQ39243004
A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acidsQ39276931
gamma-Glutamyltransferase dependent generation of reactive oxygen species from a glutathione/transferrin systemQ40993532
Hydrogen peroxide produced during gamma-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells.Q42465963
Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H(2)O(2) production, cell surface protein thiol oxidation and NF-kappa B activation status.Q42490514
Modulation of aldose reductase activity through S-thiolation by physiological thiols.Q43577680
Thiol/disulfide interconversion in bovine lens aldose reductase induced by intermediates of glutathione turnover.Q43753129
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liverQ44390227
Crystalline leucine aminopeptidase from lens (alpha-aminoacyl-peptide hydrolase; EC 3.4.11.1).Q44572171
The peptide transporter PepT2 mediates the uptake of the glutathione precursor CysGly in astroglia-rich primary culturesQ47903468
Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathioneQ48310763
Role of copper and ceruloplasmin in oxidative mutagenesis induced by the glutathione-gamma-glutamyl transpeptidase system and by other thiolsQ50136351
P433issuePt 1
P407language of work or nameEnglishQ1860
P921main subjectglutathioneQ116907
P304page(s)35-44
P577publication date2004-02-01
P1433published inBiochemical JournalQ864221
P1476titleNew role for leucyl aminopeptidase in glutathione turnover
P478volume378

Reverse relations

cites work (P2860)
Q39680572A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism
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