Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.

scientific article published on 11 March 2011

Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1001946
P932PMC publication ID3095097
P698PubMed publication ID21398610
P5875ResearchGate publication ID50376780

P50authorNataly Manjarrez-OrduñoQ67423444
Iñaki SanzQ91392897
P2093author name stringHongmei Yang
Diana G Adlowitz
Chungwen Wei
Lin Silver
Tâm D Quách
Eric C B Milner
P2860cites workCD28/B7 system of T cell costimulationQ24313544
A cellular calculus for signal integration by T cellsQ28145380
Predominant autoantibody production by early human B cell precursorsQ29619656
Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivoQ33615157
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humansQ33615168
Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic miceQ33711616
Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell toleranceQ33732451
Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.Q34063153
ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cellsQ34463998
Positive versus negative signaling by lymphocyte antigen receptorsQ34468852
BAFF: a fundamental survival factor for B cells.Q34718112
Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.Q34909737
Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of KenyaQ35101169
B cell antigen receptor signaling 101.Q35818846
Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clonesQ36026609
Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell toleranceQ36041818
The role of CD22 and other inhibitory co-receptors in B-cell activationQ36123205
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloningQ36459907
B-cell anergy: from transgenic models to naturally occurring anergic B cells?Q36887132
Balancing immunity and tolerance: deleting and tuning lymphocyte repertoiresQ37689611
Exogenous and endogenous TLR ligands activate anti-chromatin and polyreactive B cellsQ38313168
Influence of B cell antigen receptor expression level on pathways of B cell tolerance inductionQ39901565
A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.Q40790893
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigensQ41170875
Balancing immunity, autoimmunity, and self-toleranceQ41500785
CpG DNA activation and plasma-cell differentiation of CD27- naive human B cellsQ41767963
Transitional B cells are the target of negative selection in the B cell compartmentQ42026939
Identification of anergic B cells within a wild-type repertoire.Q42505673
Novel human transitional B cell populations revealed by B cell depletion therapyQ42559263
Reduced life span of anergic self-reactive B cells in a double-transgenic modelQ42942098
Breakdown of self-tolerance in anergic B lymphocytes.Q43668436
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF.Q44223059
Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytesQ44807477
B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomasQ45800947
CpG drives human transitional B cells to terminal differentiation and production of natural antibodiesQ46820205
Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21.Q51978898
A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.Q52008746
Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes.Q52060984
Persistence of functionally compromised anti-double-stranded DNA B cells in the periphery of non-autoimmune mice.Q52528588
B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice.Q54120741
B cell receptor affinity and B cell subset identity integrate to define the effectiveness, affinity threshold, and mechanism of anergy.Q64925940
The need for central and peripheral tolerance in the B cell repertoireQ68822019
The influence of antigen organization on B cell responsivenessQ72628042
Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/CD40Q73330354
Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signalingQ73378299
T cell dependent B cell activation occurs during the induction of T cell anergy by staphylococcal enterotoxin B in miceQ74485126
Maintenance of B cell anergy requires constant antigen receptor occupancy and signalingQ81299785
Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferationQ81300327
CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunityQ83119702
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)4640-4648
P577publication date2011-03-11
P1433published inJournal of ImmunologyQ3521441
P1476titleAnergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM
P478volume186

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cites work (P2860)
Q33430662A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia
Q38171305A stepwise model of polyreactivity of the T cell antigen-receptor (TCR): its impact on the self-nonself discrimination and on related observations (receptor editing, anergy, dual receptor cells).
Q49887715Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients
Q36307080Advances in human B cell phenotypic profiling
Q35903515Autopolyreactivity Confers a Holistic Role in the Immune System
Q33945747B cell receptor signaling-based index as a biomarker for the loss of peripheral immune tolerance in autoreactive B cells in rheumatoid arthritis
Q38631964B cells biology in systemic lupus erythematosus-from bench to bedside.
Q35591039B lymphocytes in neuromyelitis optica
Q50421795Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages
Q33852815Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells.
Q39303549Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.
Q41103048Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry.
Q37047327Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.
Q36863105Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells
Q57186351Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance
Q90167522Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells
Q36340820Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen
Q64262019Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity
Q46105618Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
Q37699555Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM.
Q38937343Germinal centers and autoimmune disease in humans and mice
Q35624357High Affinity Antibodies against Influenza Characterize the Plasmablast Response in SLE Patients After Vaccination
Q37414331IgD attenuates the IgM-induced anergy response in transitional and mature B cells.
Q50420195IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
Q98156793Impaired B cell anergy is not sufficient to breach tolerance to nuclear antigen in Vκ8/3H9 lupus-prone mice
Q35532322Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients.
Q37277161Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus
Q50678340PKK deficiency in B cells prevents lupus development in Sle lupus mice.
Q34245261Pathogenesis of human B cell lymphomas
Q37146459Protein kinase Cβ is required for lupus development in Sle mice
Q33829700Rationale for B cell targeting in SLE
Q33835200Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Q33555986Restoring the balance: immunotherapeutic combinations for autoimmune disease
Q55378641Role of B-cell receptors for B-cell development and antigen-induced differentiation.
Q36268482Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens
Q39370413Systematic characterization of basophil anergy
Q38975656Targeting B cells in treatment of autoimmunity
Q38085501Targeting pathological B cell receptor signalling in lymphoid malignancies
Q54219426The enigmatic function of IgD: some answers at last.
Q38107680The epigenetic landscape of B lymphocyte tolerance to self.
Q26865760The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy
Q38728631The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy
Q36838604Tolerant anti-insulin B cells are effective APCs
Q46680134Tonic Signals: Why Do Lymphocytes Bother?
Q92916578Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells

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