Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

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Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation is …
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scholarly articleQ13442814

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P356DOI10.1038/SREP25996
P932PMC publication ID4867597
P698PubMed publication ID27180681

P50authorJ Paul TaylorQ55711783
P2093author name stringDavid W Ellison
Anderson Kanagaraj
Jinghui Zhang
David Finkelstein
Hong Joo Kim
Matthew Parker
Michael Rusch
Richard J Gilbertson
Yasmine A Valentin-Vega
Yong-Dong Wang
Jennifer Moore
Deanna M Patmore
P2860cites workA Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Q53368534
Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation.Q53612654
DDX3 has divergent roles in head and neck squamous cell carcinomas in smoking versus non-smoking patients.Q54309105
DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressorQ24295660
The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational controlQ24309332
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3Q24313521
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune responseQ24336273
Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress responseQ24337086
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The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragmentsQ24634193
RNA granulesQ24683783
Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascadesQ27329678
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibitionQ27852966
Requirement of the DEAD-Box protein ded1p for messenger RNA translationQ27935125
The DEAD-box protein Ded1 modulates translation by the formation and resolution of an eIF4F-mRNA complexQ27936899
The p20 and Ded1 proteins have antagonistic roles in eIF4E-dependent translation in Saccharomyces cerevisiae.Q27937737
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Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export functionQ28289911
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongationQ28291406
Mutational landscape and significance across 12 major cancer typesQ28300353
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillizationQ28588090
Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogasterQ28661445
The mutational landscape of head and neck squamous cell carcinomaQ29614654
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granulesQ29615265
The DEAD-box protein family of RNA helicasesQ29615303
Eukaryotic stress granules: the ins and outs of translationQ29619569
Coping with stress: eIF2 kinases and translational controlQ29619787
Both G3BP1 and G3BP2 contribute to stress granule formationQ30009952
Large G3BP-induced granules trigger eIF2α phosphorylationQ30010041
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutationsQ30040534
YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.Q30635379
PONDR-FIT: a meta-predictor of intrinsically disordered amino acidsQ33902242
SF3B1 and other novel cancer genes in chronic lymphocytic leukemiaQ34093678
The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assemblyQ34464670
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granulesQ34796882
Cancer-associated mutants of RNA helicase DDX3X are defective in RNA-stimulated ATP hydrolysisQ35470624
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamicsQ35740324
Targeting DDX3 with a small molecule inhibitor for lung cancer therapyQ35822589
Novel mutations target distinct subgroups of medulloblastoma.Q36143877
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding ProteinsQ36172705
The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodiesQ36489068
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.Q36518348
Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladderQ36529907
Translational control in cancer etiologyQ36555212
The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and NucleiQ36934790
Tumor suppressors and cell metabolism: a recipe for cancer growthQ37390879
Medulloblastomics: the end of the beginningQ37469904
From unwinding to clamping - the DEAD box RNA helicase familyQ37903659
Reduced p21(WAF1/CIP1) via alteration of p53-DDX3 pathway is associated with poor relapse-free survival in early-stage human papillomavirus-associated lung cancerQ39591325
Mutations driving CLL and their evolution in progression and relapseQ39714436
Oncogenic role of DDX3 in breast cancer biogenesis.Q40014680
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphomaQ40717160
Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia.Q41485437
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitmentQ41500093
DDX3X-MLLT10 fusion in adults with NOTCH1 positive T-cell acute lymphoblastic leukemiaQ42551544
New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.Q43482067
The Human Protein Atlas--a tool for pathologyQ46431300
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)25996
P577publication date2016-05-16
P1433published inScientific ReportsQ2261792
P1476titleCancer-associated DDX3X mutations drive stress granule assembly and impair global translation
P478volume6