Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design

scientific article published on March 2005

Group I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/J.1535-7597.2005.05207.X
P932PMC publication ID1176311
P698PubMed publication ID16059439
P5875ResearchGate publication ID7688521

P2093author name stringRiccardo Bianchi
Robert K S Wong
Shih-Chieh Chuang
Lisa R Merlin
P2860cites workHomer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteinsQ22008754
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Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampusQ28248856
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Differential expression of group I metabotropic glutamate receptors in functionally distinct hippocampal interneurons.Q51402461
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.Q52056265
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Protein synthesis-dependent formation of protein kinase Mzeta in long-term potentiationQ71483805
Regulation of M-type potassium channels in mammalian sympathetic neurons: action of intracellular calcium on single channel currentsQ71822828
G-protein-independent signaling mediated by metabotropic glutamate receptorsQ73202431
Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong long-term potentiationQ73387285
Expression of metabotropic glutamate receptor subtype mRNA (mGluR1-8) in human cerebellumQ73546459
Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patientsQ73613955
Group I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cellsQ73776308
Metabotropic glutamate receptors: electrophysiological properties and role in plasticityQ78111516
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivoQ28376545
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTPQ28511269
Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channelsQ28511803
Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transductionQ28564903
Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptorsQ28569381
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sitesQ29144166
Pharmacology and functions of metabotropic glutamate receptorsQ29619150
Molecular determinants of metabotropic glutamate receptor signaling.Q32140641
Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptorQ33179400
Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893).Q33905739
Anti-epileptic activity of group II metabotropic glutamate receptor agonists (--)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (--)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795).Q34083484
Determinants of metabotropic glutamate receptor-5-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentrationQ34139041
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.Q34326346
Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortexQ34421032
Physiological roles and therapeutic potential of metabotropic glutamate receptorsQ35610972
Plasticity mechanisms underlying mGluR-induced epileptogenesisQ35834546
Calmodulin mediates Ca2+-dependent modulation of M-type K+ channelsQ36447189
Bradykinin inhibits M current via phospholipase C and Ca2+ release from IP3-sensitive Ca2+ stores in rat sympathetic neuronsQ36513808
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brainQ36761451
Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.Q38299056
Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampusQ39757955
Control of calcium oscillations by phosphorylation of metabotropic glutamate receptorsQ41168894
Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCbeta1 signaling.Q43697288
Alpha 1-adrenergic modulation of metabotropic glutamate receptor-induced calcium oscillations and glutamate release in astrocytesQ43752257
Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform burstsQ43850159
Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neuronsQ43968738
Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells.Q43996783
Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesisQ44092262
Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slicesQ44168213
PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currentsQ44386912
Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.Q44495444
Extracellular signal-regulated kinase 1/2 is required for the induction of group I metabotropic glutamate receptor-mediated epileptiform discharges.Q44723172
Group I mGluR-mediated silent induction of long-lasting epileptiform dischargesQ46480664
Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform dischargesQ46702032
Differential expression of metabotropic glutamate receptors in the hippocampus and entorhinal cortex of the rat.Q48181224
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).Q48252635
Anticonvulsant and glutamate release-inhibiting properties of the highly potent metabotropic glutamate receptor agonist (2S,2'R, 3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG-IV).Q48397152
Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing ratQ48449710
Seizures and neuronal damage induced in the rat by activation of group I metabotropic glutamate receptors with their selective agonist 3,5-dihydroxyphenylglycine.Q48520895
Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.Q48668296
Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats.Q48826396
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)63-68
P577publication date2005-03-01
P1433published inEpilepsy CurrentsQ5382972
P1476titleGroup I mGluR-induced epileptogenesis: distinct and overlapping roles of mGluR1 and mGluR5 and implications for antiepileptic drug design
P478volume5

Reverse relations

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