Adenine binding mode is a key factor in triggering the early release of NADH in coenzyme A-dependent methylmalonate semialdehyde dehydrogenase

scientific article published on 10 July 2012

Adenine binding mode is a key factor in triggering the early release of NADH in coenzyme A-dependent methylmalonate semialdehyde dehydrogenase is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.350272
P932PMC publication ID3438941
P698PubMed publication ID22782904

P2093author name stringAndré Aubry
Guy Branlant
Claude Didierjean
François Talfournier
Hélène Dubourg-Gerecke
Raphaël Bchini
Sophie Rahuel-Clermont
P2860cites workMechanistic characterization of the MSDH (methylmalonate semialdehyde dehydrogenase) from Bacillus subtilisQ24541310
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The crystal structure of a ternary complex of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa Provides new insight into the reaction mechanism and shows a novel binding mode of the 2'-phosphate of NADP+ and a novel cation binding siteQ27652916
Conserved Catalytic Residues of the ALDH1L1 Aldehyde Dehydrogenase Domain Control Binding and Discharging of the CoenzymeQ27667677
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Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver. Identity to malonate-semialdehyde dehydrogenaseQ28580151
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The first crystal structure of a thioacylenzyme intermediate in the ALDH family: new coenzyme conformation and relevance to catalysis.Q30353145
Expression, purification, crystallization and preliminary X-ray diffraction data of methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis.Q30946882
Stabilization and conformational isomerization of the cofactor during the catalysis in hydrolytic ALDHsQ33386600
Methylmalonic semialdehyde dehydrogenase deficiency: demonstration of defective valine and beta-alanine metabolism and reduced malonic semialdehyde dehydrogenase activity in cultured fibroblastsQ34166518
3-Hydroxyisobutyrate aciduria and mutations in the ALDH6A1 gene coding for methylmalonate semialdehyde dehydrogenaseQ34210330
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Invariant Thr244 is essential for the efficient acylation step of the non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutansQ41080105
Methylmalonate-semialdehyde dehydrogenase from Bacillus subtilis: substrate specificity and coenzyme A bindingQ42026908
Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenaseQ44008734
Thermal destabilization of non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Streptococcus mutans upon phosphate binding in the active siteQ46367670
Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis.Q54616768
Steady-state and pre-steady-state kinetics of coenzyme A linked aldehyde dehydrogenase from Escherichia coliQ70212624
Evidence for the chemical activation of essential cys-302 upon cofactor binding to nonphosphorylating glyceraldehyde 3-phosphate dehydrogenase from Streptococcus mutansQ73036057
Critical Glutamic Acid Residues Affecting the Mechanism and Nucleotide Specificity of Vibrio Harveyi Aldehyde DehydrogenaseQ73502642
Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenaseQ73520874
P433issue37
P407language of work or nameEnglishQ1860
P304page(s)31095-31103
P577publication date2012-07-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleAdenine binding mode is a key factor in triggering the early release of NADH in coenzyme A-dependent methylmalonate semialdehyde dehydrogenase
P478volume287