Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase

scientific article published on 21 April 2008

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M802912200
P698PubMed publication ID18426795
P5875ResearchGate publication ID5425699

P50authorThomas KukarQ42165296
Jens WiltfangQ42165310
P2093author name stringBarbara A Cottrell
Edward H Koo
Sascha Weggen
Todd E Golde
Hermann Esselmann
Claus U Pietrzik
Thomas B Ladd
Karlheinz Baumann
Robert Schubenel
Sabine Paul
Stefanie Leuchtenberger
Justin W Torpey
Eva Czirr
P2860cites workPurification and characterization of the human gamma-secretase complexQ24300026
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer diseaseQ24676480
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseQ24676498
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 productionQ28245521
The gamma-secretase complex: membrane-embedded proteolytic ensembleQ28248433
The same gamma-secretase accounts for the multiple intramembrane cleavages of APPQ28284426
Presenilin clinical mutations can affect gamma-secretase activity by different mechanismsQ28290934
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activityQ33187378
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Q33276402
Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse modelQ34195981
Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.Q34649758
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor proteinQ35065215
Disease modifying therapy for AD?Q36640414
Selective modulation of Abeta42 production in Alzheimer's disease: non-steroidal anti-inflammatory drugs and beyond.Q36653723
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulationQ40061988
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.Q40076266
gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domainQ40374588
Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.Q40467990
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.Q40472233
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activityQ43793656
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generationQ44362261
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.Q44460129
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformationQ45078363
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutationsQ48134209
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.Q51468621
N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.Q53382308
P433issue25
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)17049-17054
P577publication date2008-04-21
P1433published inJournal of Biological ChemistryQ867727
P1476titleIndependent generation of Abeta42 and Abeta38 peptide species by gamma-secretase
P478volume283

Reverse relations

cites work (P2860)
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