DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model.

scientific article published on 31 July 2014

DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1041142465
P356DOI10.1038/GT.2014.67
P698PubMed publication ID25077772

P50authorMeng-Chi YenQ60679346
P2093author name stringC-Y Wang
J-Y Chang
Y-L Chen
M-D Lai
C-T Huang
W-C Chen
J-J Hung
T-Y Weng
P2860cites workEGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinibQ24561953
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Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutationQ73734358
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Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcomeQ81897940
K-ras mutations in non-small-cell lung carcinoma: a reviewQ33997955
Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human DiseasesQ34272277
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studiesQ34293555
Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.Q34536780
Xenogeneic Human p53 DNA Vaccination by Electroporation Breaks Immune Tolerance to Control Murine Tumors Expressing Mouse p53Q34607207
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptorsQ34666826
Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapyQ34701196
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Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteinsQ35108258
Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapyQ35917802
DNA vaccination in the skin using microneedles improves protection against influenzaQ36085414
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DNA vaccines: precision tools for activating effective immunity against cancer.Q37064852
The effects of DNA formulation and administration route on cancer therapeutic efficacy with xenogenic EGFR DNA vaccine in a lung cancer animal modelQ37103859
The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methodsQ37464882
Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumorsQ37659577
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancerQ38019976
KRAS Mutation: Should We Test for It, and Does It Matter?Q38080822
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancerQ38432430
Global estimates of cancer prevalence for 27 sites in the adult population in 2008.Q38920305
Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer.Q39478032
GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway InhibitionQ39606314
Targeting mutated K-ras in pancreatic adenocarcinoma using an adjuvant vaccine.Q39850362
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclQ40093939
Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysisQ40185427
Autologous neu DNA vaccine can be as effective as xenogenic neu DNA vaccine by altering administration routeQ40233983
Prognostic factors in NSCLC. Recent experiencesQ40408769
DNA immunization via intramuscular and intradermal routes using a gene gun provides different magnitudes and durations on immune responseQ40595243
IFN-gamma induces IL-12 mRNA expression by a murine macrophage cell line, J774.Q41487690
The relationship between KRAS gene mutations and HLA class I antigen downregulation in the metastasis of non-small cell lung cancerQ42274351
Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringeQ43697584
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancerQ44425380
CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccinationQ45864088
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinibQ46618741
Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.Q46941018
Delivery of noncarrier naked DNA vaccine into the skin by supersonic flow induces a polarized T helper type 1 immune response to cancerQ47862682
The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancerQ50864449
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Naked DNA and adenoviral immunizations for immunotherapy of prostate cancer: a phase I/II clinical trialQ53773145
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)888-896
P577publication date2014-07-31
P1433published inGene TherapyQ15763095
P1476titleDNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
P478volume21

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cites work (P2860)
Q92783310ADAM17: An Emerging Therapeutic Target for Lung Cancer
Q55079595Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation.
Q99237818Recombinant KRAS G12D Protein Vaccines Elicit Significant Anti-Tumor Effects in Mouse CT26 Tumor Models
Q47137503Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8+ Immunity In Vivo.

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