Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).

scientific article published on August 1987

Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+). is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-291X(87)80129-8
P8608Fatcat IDrelease_mlw2e5knvfekpiz2x4s2ootvha
P698PubMed publication ID3632675

P2093author name stringFelix CC
Kalyanaraman B
Korytowski W
P2860cites workOxidative ionic metabolites of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): correlation of electroreduction with physiological behaviorQ68856602
Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+)Q69014447
A catalyst function for MPTP in superoxide formationQ70103979
Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion (MPP+): reductive activation by NADPH cytochrome P-450 reductaseQ70136757
The regional distribution and cellular localization of iron in the rat brainQ71334738
An electron spin resonance study of the novel radical cation produced during the horseradish peroxidase-catalyzed oxidation of tetramethylhydrazineQ72935271
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesisQ22242250
Pargyline Prevents MPTP-Induced Parkinsonism in PrimatesQ28266115
Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkeyQ28270776
Chronic parkinsonism secondary to intravenous injection of meperidine analoguesQ28323857
Bioactivation of MPTP: reactive metabolites and possible biochemical sequelaeQ42216518
Metabolism of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by liver homogenate fractionsQ42224865
The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metalsQ43466545
Interactions of the 1-methyl-4-phenyl-2,3-dihydropyridinium species with synthetic dopamine-melaninQ43629917
Brain Peroxidase and Catalase in Parkinson DiseaseQ44295221
Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatmentQ48386729
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamateQ48427450
Studies on the mechanism of action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).Q48535155
Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effectsQ48535241
Oxidation of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by monoamine oxidases A and B and suicide inactivation of the enzymes by MPTPQ48590320
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitorsQ48614146
Brain enzyme is the target of drug toxinQ48621296
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidaseQ48681443
One-electron reactions in biochemical systems as studied by pulse radiolysis. I. Nicotinamide-adenine dinucleotide and related compoundsQ68583864
Chemically induced Parkinson's disease: intermediates in the oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to the 1-methyl-4-phenyl-pyridinium ionQ68820409
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)354-360
P577publication date1987-08-01
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleEvidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).
P478volume147

Reverse relations

cites work (P2860)
Q45106981Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-methyl-1,2,3,6-tetrahydropyridines
Q37045190MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

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