methotrexate

chemical compound

Wikidata entity: Q422232

C₂₀H₂₂N₈O₅ (P274)


Wikimedia Commons category is Methotrexate

Quantities

P4250defined daily dose2.5
P2067mass454.171

P3780 active ingredient in ... Q29006226 (Nordimet) Nordimet
P3780 active ingredient in ... Q47521949 (Otrexup) Otrexup
P3780 active ingredient in ... Q47522087 (Rheumatrex) Rheumatrex
P3780 active ingredient in ... Q47522224 (Trexall) Trexall
P3780 active ingredient in ... Q47522318 (Xatmep) Xatmep
P3780 active ingredient in ... Q48828089 (Rasuvo) Rasuvo
P233 canonical SMILES String CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O ???
P373 Commons category String Methotrexate ???
P703 found in taxon ... Q948827 (Asimina triloba) Asimina triloba
P703 found in taxon ... Q1809933 (Dolichousnea longissima) Dolichousnea longissima
P703 found in taxon ... Q10648042 (Quambalaria cyanescens) Quambalaria cyanescens
P703 found in taxon ... Q18601090 (Gambierdiscus) Gambierdiscus
P366 has use ... Q12140 (medication) medication
P31 instance of ... Q113145171 (type of chemical entity) type of chemical entity
P2017 isomeric SMILES String CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O ???
P3493 legal status (medicine) ... Q879952 (boxed warning) boxed warning
P176 manufacturer ... Q206921 (Pfizer) Pfizer
P2175 medical condition treated ... Q1477 (ulcerative colitis) ulcerative colitis
P2175 medical condition treated ... Q29496 (leukemia) leukemia
P2175 medical condition treated ... Q52849 (ankylosing spondylitis) ankylosing spondylitis
P2175 medical condition treated ... Q128581 (breast cancer) breast cancer
P2175 medical condition treated ... Q136312 (central nervous system lymphoma) central nervous system lymphoma
P2175 medical condition treated ... Q170990 (arthritis) arthritis
P2175 medical condition treated ... Q187255 (rheumatoid arthritis) rheumatoid arthritis
P2175 medical condition treated ... Q189588 (stomach cancer) stomach cancer
P2175 medical condition treated ... Q207087 (ectopic pregnancy) ectopic pregnancy
P2175 medical condition treated ... Q208414 (lymphoma) lymphoma
P2175 medical condition treated ... Q264118 (acute myeloid leukemia) acute myeloid leukemia
P2175 medical condition treated ... Q324464 (testicular cancer) testicular cancer
P2175 medical condition treated ... Q280027 (uveitis) uveitis
P2175 medical condition treated ... Q372701 (esophageal cancer) esophageal cancer
P2175 medical condition treated ... Q549534 (osteosarcoma) osteosarcoma
P2175 medical condition treated ... Q612108 (acute promyelocytic leukemia) acute promyelocytic leukemia
P2175 medical condition treated ... Q707816 (giant cell arteritis) giant cell arteritis
P2175 medical condition treated ... Q861224 (juvenile rheumatoid arthritis) juvenile rheumatoid arthritis
P2175 medical condition treated ... Q980926 (polymyositis) polymyositis
P2175 medical condition treated ... Q1004647 (bullous pemphigoid) bullous pemphigoid
P2175 medical condition treated ... Q1138590 (non-Hodgkin lymphoma) non-Hodgkin lymphoma
P2175 medical condition treated ... Q1161568 (granulomatosis with polyangiitis) granulomatosis with polyangiitis
P2175 medical condition treated ... Q1274464 (polyarthritis) polyarthritis
P2175 medical condition treated ... Q1752891 (polymyalgia rheumatica) polymyalgia rheumatica
P2175 medical condition treated ... Q1783924 (head and neck cancer) head and neck cancer
P2175 medical condition treated ... Q2626074 (diffuse large B-cell lymphoma) diffuse large B-cell lymphoma
P2175 medical condition treated ... Q1891209 (mycosis fungoides) mycosis fungoides
P2175 medical condition treated ... Q4676432 (acropustulosis) acropustulosis
P2175 medical condition treated ... Q4833719 (B-cell lymphoma) B-cell lymphoma
P2175 medical condition treated ... Q7239590 (precursor T-cell lymphoblastic leukemia) precursor T-cell lymphoblastic leukemia
P2175 medical condition treated ... Q7667896 (T-cell lymphoma) T-cell lymphoma
P2175 medical condition treated ... Q7845637 (trophoblastic neoplasm) trophoblastic neoplasm
P2175 medical condition treated ... Q17148432 (systemic-onset juvenile idiopathic arthritis) systemic-onset juvenile idiopathic arthritis
P2175 medical condition treated ... Q18556020 (lung benign neoplasm) lung benign neoplasm
P2175 medical condition treated ... Q18975788 (spindle cell sarcoma) spindle cell sarcoma
P2175 medical condition treated ... Q55781316 (osteoarthritis susceptibility 1) osteoarthritis susceptibility 1
P2175 medical condition treated ... Q55789426 (precursor T-cell acute lymphoblastic leukemia) precursor T-cell acute lymphoblastic leukemia
P2175 medical condition treated ... Q56014449 (precursor B-cell acute lymphoblastic leukemia) precursor B-cell acute lymphoblastic leukemia
P2175 medical condition treated ... Q56014469 (bone sarcoma) bone sarcoma
P361 part of ... Q14819383 (response to methotrexate) response to methotrexate
P361 part of ... Q21121083 (methotrexate transmembrane transporter activity) methotrexate transmembrane transporter activity
P361 part of ... Q21173728 (cellular response to methotrexate) cellular response to methotrexate
P129 physically interacts with ... Q21121086 (solute carrier family 46 member 1) solute carrier family 46 member 1
P129 physically interacts with ... Q21126218 (solute carrier family 19 member 1) solute carrier family 19 member 1
P3489 pregnancy category ... Q3679274 (Australian pregnancy category D) Australian pregnancy category D
P3489 pregnancy category ... Q28123619 (US pregnancy category X) US pregnancy category X
P636 route of administration ... Q285166 (oral administration) oral administration
P636 route of administration ... Q432083 (intramuscular injection) intramuscular injection
P636 route of administration ... Q640448 (intravenous infusion and defusion) intravenous infusion and defusion
P636 route of administration ... Q1320251 (intrathecal administration) intrathecal administration
P769 significant drug interaction ... Q18216 (aspirin) aspirin
P769 significant drug interaction ... Q45050 (tenoxicam) tenoxicam
P769 significant drug interaction ... Q186969 (ibuprofen) ibuprofen
P769 significant drug interaction ... Q244408 (Diclofenac) Diclofenac
P769 significant drug interaction ... Q341500 (acitretin) acitretin
P769 significant drug interaction ... Q409192 ((RS)-ketoprofen) (RS)-ketoprofen
P769 significant drug interaction ... Q409231 (indomethacin) indomethacin
P769 significant drug interaction ... Q347941 (parecoxib) parecoxib
P769 significant drug interaction ... Q367700 (cyclosporine) cyclosporine
P769 significant drug interaction ... Q408676 (piroxicam) piroxicam
P769 significant drug interaction ... Q408801 (celecoxib) celecoxib
P769 significant drug interaction ... Q414028 (meloxicam) meloxicam
P769 significant drug interaction ... Q415843 (sulfamethoxazole) sulfamethoxazole
P769 significant drug interaction ... Q425207 (nabumetone) nabumetone
P769 significant drug interaction ... Q481757 (aceclofenac) aceclofenac
P769 significant drug interaction ... Q419890 ((±)-flurbiprofen) (±)-flurbiprofen
P769 significant drug interaction ... Q420387 (foscarnet) foscarnet
P769 significant drug interaction ... Q422665 (trimethoprim) trimethoprim
P769 significant drug interaction ... Q963093 (sulindac) sulindac
P769 significant drug interaction ... Q1215575 (naproxen) naproxen
P769 significant drug interaction ... Q2465218 ((RS)-etodolac) (RS)-etodolac
P769 significant drug interaction ... Q2555245 ((RS)-fenoprofen) (RS)-fenoprofen
P3364 stereoisomer of ... Q27292170 ((R)-methotrexate) (R)-methotrexate
P279 subclass of ... Q27165469 (Amethopterin) Amethopterin
P2868 subject has role ... Q35456 (essential medicine) essential medicine
P2868 subject has role ... Q127060 (folic acid) folic acid
P2868 subject has role ... Q249619 (immunosuppressive drug) immunosuppressive drug
P2868 subject has role ... Q427492 (enzyme inhibitor) enzyme inhibitor
P2868 subject has role ... Q810254 (disease-modifying antirheumatic drug) disease-modifying antirheumatic drug
P2868 subject has role ... Q4118287 (DNA polymerase inhibitors) DNA polymerase inhibitors
P2868 subject has role ... Q1809112 (dermatologic drug) dermatologic drug
P2868 subject has role ... Q50415114 (Abortifacient Agents, Nonsteroidal) Abortifacient Agents, Nonsteroidal
P2868 subject has role ... Q50429867 (antineoplastic antimetabolite) antineoplastic antimetabolite
P2868 subject has role ... Q50573407 (folic acid antagonists) folic acid antagonists
P2868 subject has role ... Q72941151 (developmental toxicant) developmental toxicant
P2275 World Health Organisation international non-proprietary name Monolingualtext methotrexate ???
External Ids
P267ATC codeL01BA01
P267ATC codeL04AX03
P7524CA PROP 65 IDmethotrexate
P11931CAMEO Chemicals ID20602
P231CAS Registry Number59-05-2
P683ChEBI ID44185
P592ChEMBL IDCHEMBL34259
P661ChemSpider ID112728
P3073CosIng number95795
P9272DeCS ID28169
P715DrugBank IDDB00563
P11198DrugCentral ID1751
P8494DSSTOX compound identifierDTXCID80822
P3117DSSTox substance IDDTXSID4020822
P232EC number200-413-8
P2566ECHA Substance Infocard ID100.000.376
P9635electronic Essential Medicines List medicine ID99
P1417Encyclopædia Britannica Online IDscience/methotrexate
P646Freebase ID/m/01q2jc
P227GND ID4038985-6
P12385Gran Enciclopèdia Catalana IDmetotrexat
P1296Gran Enciclopèdia Catalana ID (former scheme)0123343
P595Guide to Pharmacology Ligand ID4815
P595Guide to Pharmacology Ligand ID4674
P2062HSDB ID3123
P2057Human Metabolome Database IDHMDB0014703
P4168IEDB Epitope ID230085
P234InChIInChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
P235InChIKeyFBOZXECLQNJBKD-ZDUSSCGKSA-N
P665KEGG IDD00142
P244Library of Congress authority IDsh85084418
P6689MassBank accession IDMSBNK-Athens_Univ-AU273001
P6689MassBank accession IDMSBNK-Athens_Univ-AU273002
P6689MassBank accession IDMSBNK-Athens_Univ-AU273003
P6689MassBank accession IDMSBNK-Athens_Univ-AU273004
P6689MassBank accession IDMSBNK-Athens_Univ-AU273005
P6689MassBank accession IDMSBNK-Athens_Univ-AU273006
P10245MedlinePlus drug identifiera682018
P10245MedlinePlus drug identifiera682019
P6694MeSH concept IDM0013595
P486MeSH descriptor IDD008727
P672MeSH tree codeD03.633.100.733.631.192.500
P6366Microsoft Academic ID (discontinued)2781059491
P6366Microsoft Academic ID (discontinued)2908869771
P2004NALT ID10468
P3640National Drug Code61703-408
P3640National Drug Code61703-350
P8189National Library of Israel J9U ID987007529313305171
P2115NDF-RT IDN0000147916
P2840NSC number740
P10283OpenAlex IDC2781059491
P10283OpenAlex IDC2909950847
P12594OSHA Occupational Chemical Database ID874
P4235PatientsLikeMe treatment IDmethotrexate
P3636PDB ligand IDMTX
P638PDB structure ID1D1G
P638PDB structure ID3HJ3
P638PDB structure ID1DRA
P638PDB structure ID2QK8
P638PDB structure ID1U70
P638PDB structure ID3QXV
P638PDB structure ID1RB3
P638PDB structure ID1DF7
P638PDB structure ID1MXF
P638PDB structure ID4DFR
P638PDB structure ID1DLS
P638PDB structure ID2C7V
P638PDB structure ID4P66
P638PDB structure ID3EIG
P638PDB structure ID3QXT
P638PDB structure ID1U72
P638PDB structure ID4KN0
P638PDB structure ID3IA4
P638PDB structure ID4P68
P638PDB structure ID5HI6
P638PDB structure ID1DDR
P638PDB structure ID1DRE
P638PDB structure ID4KY8
P638PDB structure ID1RA3
P638PDB structure ID4Q0D
P638PDB structure ID3DAU
P638PDB structure ID1DDS
P638PDB structure ID1AO8
P638PDB structure ID1AXW
P638PDB structure ID1RH3
P638PDB structure ID1E7W
P638PDB structure ID3DAT
P638PDB structure ID1RG7
P638PDB structure ID1RX3
P638PDB structure ID4L8W
P638PDB structure ID4L6H
P638PDB structure ID1TDR
P638PDB structure ID4QI9
P638PDB structure ID1DHJ
P638PDB structure ID2OIP
P638PDB structure ID3DFR
P638PDB structure ID1DRB
P638PDB structure ID3IX9
P638PDB structure ID2DRC
P638PDB structure ID4L8F
P638PDB structure ID5J7W
P638PDB structure ID4GH8
P638PDB structure ID1P33
P638PDB structure ID3CD2
P638PDB structure ID3DRC
P638PDB structure ID3TQ9
P638PDB structure ID1DHI
P638PDB structure ID3CL9
P11199Probes And Drugs IDPD002823
P662PubChem CID126941
P3417Quora topic IDMethotrexate
P1579Reaxys registry number70669
P3345RxNorm CUI6851
P5076Römpp online IDRD-13-01707
P4964SPLASHsplash10-0fai-6900000000-25b0e287457fb3845ef4
P5082Store medisinske leksikon IDmetotreksat
P2877SureChEMBL ID3711
P4527UK Parliament thesaurus ID11575
P2892UMLS CUIC0025677
P11089UniChem compound ID647984
P652UNIIYL5FZ2Y5U1
P11143WikiProjectMed IDMethotrexate
P3471WikiSkripta article ID7572
P8814WordNet 3.1 Synset ID03761241-n
P13591Yale LUX IDconcept/0ec2699c-0443-4233-9d12-52a8c8cc355c
P679ZVG number490067

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