Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice

scientific article published on 24 October 2013

Two amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VIRUSRES.2013.10.002
P698PubMed publication ID24512754

P50authorHualan ChenQ107321893
P2093author name stringLin Zhang
Xiumei Zhang
Qinghua Huang
Shaohua Yang
Beixia Hu
Chuantian Xu
P2860cites workThe evolution of H5N1 influenza viruses in ducks in southern ChinaQ24564166
Influenza virus M2 protein mediates ESCRT-independent membrane scissionQ24634367
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virusQ27663887
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channelQ27664419
Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid BilayerQ27665298
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virusQ27675846
The active sites of the influenza cap-dependent endonuclease are on different polymerase subunitsQ27863698
Molecular basis for high virulence of Hong Kong H5N1 influenza A virusesQ29619144
The molecular basis of the specific anti-influenza action of amantadineQ33931939
Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse modelQ33987340
Lethal H5N1 influenza viruses escape host anti-viral cytokine responsesQ34146021
Influenza virus M2 protein has ion channel activityQ34248853
Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western ChinaQ34651554
The amino-terminal one-third of the influenza virus PA protein is responsible for the induction of proteolysisQ35857444
A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickensQ36423951
A single-amino-acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in miceQ36424206
The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer.Q36764097
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.Q37830140
Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active siteQ38303101
The replication activity of influenza virus polymerase is linked to the capacity of the PA subunit to induce proteolysis.Q39588256
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAsQ39684553
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAsQ39742027
High prevalence of amantadine resistance among circulating European porcine influenza A virusesQ39882839
Influenza virus infection causes specific degradation of the largest subunit of cellular RNA polymerase II.Q40162019
Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA.Q40340454
Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter bindingQ43156905
Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surfaceQ43551346
Ser624 of the PA subunit of Influenza A virus is not essential for viral growth in cells and mice, but required for the maximal viral growthQ44593305
Creation of amantadine resistant clones of influenza type A virus using a new transfection procedureQ45757403
How do aminoadamantanes block the influenza M2 channel, and how does resistance develop?Q84012354
P577publication date2013-10-24
P1433published inVirus ResearchQ15749215
P1476titleTwo amino acid residues in ion channel protein M2 and polymerase protein PA contribute to replication difference of H5N1 influenza viruses in mice

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