Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity

scientific article published on 11 June 2008

Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBAMCR.2008.05.027
P932PMC publication ID2629733
P698PubMed publication ID18602426
P5875ResearchGate publication ID5249637

P50authorXingshun XuQ39706435
Ye XiongQ42092081
P2093author name stringHong Wang
Jinping Gao
Balvin H L Chua
Ronald Hamdy
Ye-Shih Ho
Chu Chang Chua
Xuwan Liu
P2860cites workNitric oxide and peroxynitrite in health and diseaseQ24645400
Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicityQ24648835
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalingQ28252897
Anthracycline cardiomyopathy monitored by morphologic changesQ28332787
Myocardial injury induced by a single dose of adriamycin: an electron microscopic studyQ28335798
The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liverQ28510597
Hydroperoxide metabolism in mammalian organsQ29614205
Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice.Q31399901
Apoptosis in isolated adult cardiomyocytes exposed to adriamycinQ33178685
A clinicopathologic analysis of adriamycin cardiotoxicityQ34207498
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxiaQ34430043
Early anthracycline cardiotoxicityQ34714914
Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicinQ34718010
Biochemistry of peroxisomesQ35261940
Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivoQ36431848
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic miceQ37359529
Doxorubicin cardiotoxicity: analysis of prevailing hypothesesQ37958656
Age-related acute adriamycin cardiotoxicity in miceQ38570782
Vascular peroxynitrite formation during organic nitrate tolerance.Q39517974
Doxorubicin toxicity in perfused rat heart. Decreased cell death at low oxygen tensionQ41185866
Kinetic studies on the removal of extracellular hydrogen peroxide by cultured fibroblastsQ41494700
Manganese superoxide dismutase protects mitochondrial complex I against adriamycin-induced cardiomyopathy in transgenic miceQ42536571
Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic miceQ43572787
Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytesQ43675500
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failureQ43893501
Melatonin as an effective protector against doxorubicin-induced cardiotoxicityQ44027007
Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunctionQ44319426
Melatonin stimulates the activity of protective antioxidative enzymes in myocardial cells of rats in the course of doxorubicin intoxicationQ44558496
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicityQ44725738
Enhanced gene expression of myocardial matrix metalloproteinases 2 and 9 after acute treatment with doxorubicin in miceQ46925252
Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.Q51706854
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C.Q52442158
Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase.Q52462539
Glutathione Peroxidase, V. The kinetic mechanismQ52977542
Acute doxorubicin cardiotoxicity: functional, metabolic, and morphologic alterations in the isolated, perfused rat heart.Q54423854
Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice.Q55001119
Damages of the mitochondrial membrane in adriamycin treated miceQ56935714
Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicityQ69835271
Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic miceQ71119918
Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicksQ71375904
Free radical-dependent DNA lesions are involved in the delayed cardiotoxicity induced by adriamycin in the ratQ72199967
Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucolQ73108705
MAPK superfamily plays an important role in daunomycin-induced apoptosis of cardiac myocytesQ73184271
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosisQ73678982
Attenuation of doxorubicin-induced contractile and mitochondrial dysfunction in mouse heart by cellular glutathione peroxidaseQ79743967
P433issue10
P921main subjectglutathioneQ116907
P304page(s)2020-2029
P577publication date2008-06-11
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleGlutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity
P478volume1783

Reverse relations

cites work (P2860)
Q38542462Anthracycline-Induced Cardiomyopathy in Adults
Q37421187Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron
Q91677554Control of doxorubicin-induced, reactive oxygen-related apoptosis by glutathione peroxidase 1 in cardiac fibroblasts
Q34255916Dexrazoxane for the prevention of cardiac toxicity and treatment of extravasation injury from the anthracycline antibiotics
Q58862883Genetic variants inSLC22A17 and SLC22A7are associated with anthracycline-induced cardiotoxicity in children
Q38023790Impact of dietary selenium intake on cardiac health: experimental approaches and human studies
Q39636367In vivo and in vitro assessment of the role of glutathione antioxidant system in anthracycline-induced cardiotoxicity
Q92309822Mechanisms of Anthracycline-Enhanced Reactive Oxygen Metabolism in Tumor Cells
Q34300952Mouse Models of Oxidative Stress Indicate a Role for Modulating Healthy Aging
Q56990436Mouse Models that Target Individual Selenoproteins
Q36281925Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development
Q37421153Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress
Q36568908Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection.
Q28392715Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Q39211305Phenotypic profiling of structural cardiotoxins in vitro reveals dependency on multiple mechanisms of toxicity
Q90631665Prevention of Doxorubicin-Induced Autophagy Attenuates Oxidative Stress and Skeletal Muscle Dysfunction
Q33798040Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3
Q27026075Regulation of cell survival and death by pyridine nucleotides
Q50192080Selenoproteins and cardiovascular stress
Q36467928Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer.
Q41929473p21(WAF1/Cip1/Sdi1) knockout mice respond to doxorubicin with reduced cardiotoxicity

Search more.