Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node.

scientific article published on 5 June 2012

Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBRC.2012.05.148
P8608Fatcat IDrelease_bbin7fy46rdivo6wtmlvqeyabu
P932PMC publication ID3400056
P698PubMed publication ID22683635
P5875ResearchGate publication ID225286679

P50authorAndrew F. JamesQ69846071
P2093author name stringJules C Hancox
Stéphanie C M Choisy
P2860cites workInwardly rectifying potassium channels: their structure, function, and physiological rolesQ24296441
The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocksQ24674614
Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificityQ28242985
Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heartQ34221438
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Structure-function relationship in the AV junctionQ35887916
Genesis and regulation of the heart automaticity.Q37216067
Morphology and electrophysiology of the mammalian atrioventricular nodeQ38187243
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"Fade" of hyperpolarizing responses to vagal stimulation at the sinoatrial and atrioventricular nodes of the rabbit heartQ41498155
One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells.Q41866771
Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.Q41906789
Desensitization to acetylcholine in single sinoatrial node cells isolated from rabbit heartsQ42453714
Altered cardiovascular responses in mice lacking the M(1) muscarinic acetylcholine receptorQ42519027
Regulation by acetylcholine of Ca2+ current in rabbit atrioventricular node cellsQ42528801
Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca(2+) ATPaseQ42650296
The role of muscarinic K(+) channels in the negative chronotropic effect of a muscarinic agonistQ43863097
Ionic basis of depressed automaticity and conduction by acetylcholine in rabbit AV nodeQ43958727
Anticholinergic action of quinidine sulfate in the rabbit atrioventricular nodeQ44939697
Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow.Q45086579
Calcium tolerant ventricular myocytes prepared by preincubation in a "KB medium".Q46180941
Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular nodeQ46297721
The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonistsQ46410232
Nitric oxide synthase (NOS3)-mediated cholinergic modulation of Ca2+ current in adult rabbit atrioventricular nodal cells.Q50539341
Frequency-dependent effects of propofol on atrioventricular nodal conduction in guinea pig isolated heart. Mechanism and potential antidysrhythmic properties.Q51597766
Control of the cardiac muscarinic K+ channel by beta-arrestin 2.Q52863253
Receptor kinase-dependent desensitization of the muscarinic K+ current in rat atrial cells.Q52870284
Secondary AV conduction responses during tonic vagal stimulation.Q53882118
Functional participation in M1 receptor subtype on chronotropic and dromotropic responses to vagus stimulation in anesthetized dogs.Q54076073
Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heartQ59068860
Role of internalization of M2 muscarinic receptor via clathrin-coated vesicles in desensitization of the muscarinic K+ current in heartQ59594732
Adenosine increases potassium conductance in isolated rabbit atrioventricular nodal myocytesQ70987473
Maintained prolongation of AV conduction time by acetylcholineQ71390665
A method for making rapid changes of superfusate whilst maintaining temperature at 37 degrees CQ71440859
Electrophysiological properties of morphologically distinct cells isolated from the rabbit atrioventricular nodeQ71517413
Ionic basis of the chronotropic effect of acetylcholine on the rabbit sinoatrial nodeQ72013318
The hyperpolarisation-activated current, I(f), is not required for pacemaking in single cells from the rabbit atrioventricular nodeQ72124824
On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cellsQ72578571
A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and functionQ72917580
Concealed conduction further evaluation of a fundamental aspect of propagation of the cardiac impulseQ74210103
Role of receptor kinase in short-term desensitization of cardiac muscarinic K+ channels expressed in Chinese hamster ovary cellsQ74367661
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectdesensitizationQ2700499
P304page(s)496-502
P577publication date2012-06-05
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleAcute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node
P478volume423

Reverse relations

cites work (P2860)
Q39785206Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology.
Q37575021Cardiac inotropic rebound effect after washout of acetylcholine is associated with electrophysiological heterogeneity in Langendorff-perfused rabbit heart
Q91851182Clinical evidence-guided network pharmacology analysis reveals a critical contribution of β1-adrenoreceptor upregulation to bradycardia alleviation by Shenxian-Shengmai
Q92105453Transmural Autonomic Regulation of Cardiac Contractility at the Intact Heart Level

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