Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response

scientific article published on July 2013

Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3700440
P698PubMed publication ID24101791

P50authorVolker GerdtsQ96650456
Robert BrownlieQ116693061
George MutwiriQ116693068
P2093author name stringAndrew L Allen
A Marianela Lopez
Andrew Potter
Hugh G G Townsend
Katharina L Lohmann
Stephen T Manning
Fernando J Marques
Anna E Sangster
P2860cites workInvolvement of interferon-gamma and tumor necrosis factor-alpha in host defense against Rhodococcus equi.Q64989616
Use of Rhodococcus equi virulence-associated protein for immunization of foals against R equi pneumoniaQ73214654
Protective effect against Rhodococcus equi infection in mice of IgG purified from horses vaccinated with virulence associated protein (VapA)-enriched antigensQ73518044
Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horsesQ73887647
Foal IgG and opsonizing anti-Rhodococcus equi antibodies after immunization of pregnant mares with a protective VapA candidate vaccineQ80973192
Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infectionQ82150578
Neutrophil function of neonatal foals is enhanced in vitro by CpG oligodeoxynucleotide stimulationQ83130493
Foals are interferon gamma-deficient at birthQ83168358
Activation of foal neutrophils at different ages by CpG oligodeoxynucleotides and Rhodococcus equiQ84695813
Rhodococcus equi: clinical manifestations, virulence, and immunityQ27686909
Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foalsQ33769350
Immunoglobulin G subisotype responses of pneumonic and healthy, exposed foals and adult horses to Rhodococcus equi virulence-associated proteinsQ34995966
Biological activity of immunostimulatory CpG DNA motifs in domestic animalsQ35051447
Cytokine modulation alters pulmonary clearance of Rhodococcus equi and development of granulomatous pneumonia.Q35429473
Transfer of a CD4+ Th1 cell line to nude mice effects clearance of Rhodococcus equi from the lungQ35479447
Virulence-associated 15- to 17-kilodalton antigens in Rhodococcus equi: temperature-dependent expression and location of the antigensQ36948187
Current understanding of the equine immune response to Rhodococcus equi. An immunological review of R. equi pneumoniaQ37671950
Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equiQ39662363
Clearance of virulent but not avirulent Rhodococcus equi from the lungs of adult horses is associated with intracytoplasmic gamma interferon production by CD4+ and CD8+ T lymphocytesQ39736340
Virulence-associated protein-specific serum immunoglobulin G-isotype expression in young foals protected against Rhodococcus equi pneumonia by oral immunization with virulent R. equiQ40500745
Prevention of Rhodococcus equi pneumonia of foals using two different inactivated vaccinesQ40649369
Basal and stimulus-induced cytokine expression is selectively impaired in peripheral blood mononuclear cells of newborn foalsQ42445939
The effect of CpG-ODN on antigen presenting cells of the foalQ42957702
CpG ODN can re-direct the Th bias of established Th2 immune responses in adult and young miceQ43828300
Evaluation of equine immunoglobulin specific for Rhodococcus equi virulence-associated proteins A and C for use in protecting foals against Rhodococcus equi-induced pneumoniaQ44809810
Comparison of selective media for the isolation of Rhodococcus equi and description of a new selective plating mediumQ46697671
Safety and immunogenicity of a live-attenuated auxotrophic candidate vaccine against the intracellular pathogen Rhodococcus equiQ46869532
Young foal and adult horse monocyte-derived dendritic cells differ by their degree of phenotypic maturity.Q51732880
Immunization by intrabronchial administration to 1-week-old foals of an unmarked double gene disruption strain of Rhodococcus equi strain 103+.Q52579722
P433issue3
P921main subjectfoalQ45614
P304page(s)161-169
P577publication date2013-07-01
P1433published inCanadian Journal of Veterinary ResearchQ15761321
P1476titleFailure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response
P478volume77

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cites work (P2860)
Q33693942Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate
Q33658921Vaccination of Mice with Virulence-Associated Protein G (VapG) Antigen Confers Partial Protection against Rhodococcus equi Infection through Induced Humoral Immunity

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