Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver

scientific article published on August 2000

Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/0264-6021:3500207
P8608Fatcat IDrelease_dqxifixqsnf2xj43ffp56p7gia
P932PMC publication ID1221243
P698PubMed publication ID10926845
P5875ResearchGate publication ID12393320

P2093author name stringHäussinger D
Block C
Graf D
Schliess F
Kurz AK
Dahl SV
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Proteins regulating Ras and its relativesQ28257295
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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factorQ28775865
The mitogen-activated protein kinase signal transduction pathwayQ29620226
Mitogen-activated protein kinases: specific messages from ubiquitous messengersQ30303652
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinaseQ30450248
Tauroursodeoxycholic acid stimulates hepatocellular exocytosis and mobilizes extracellular Ca++ mechanisms defective in cholestasisQ33910573
Involvement of microtubules in the link between cell volume and pH of acidic cellular compartments in rat and human hepatocytesQ35767601
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinaseQ38298684
Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and childrenQ40457634
Hepatoprotection by hydrophilic bile saltsQ40649152
Ursodiol for hepatobiliary disordersQ40664612
Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bileQ40952050
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeastQ40974442
LY294002-mediated inhibition of phosphatidylinositol 3-kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos-Burkitt lymphoma B cellsQ41010076
Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras.Q41128325
Role of anion translocation across the mitochondrial membrane in the regulation of urea synthesis from ammonia by isolated rat hepatocytesQ41790808
Cell volume and bile acid excretionQ41836065
Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cellsQ42021777
Mechanism of inhibition of Raf-1 by protein kinase A.Q42030118
Cell swelling increases bile flow and taurocholate excretion into bile in isolated perfused rat liverQ42123790
Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytesQ42454944
Effects of tauroursodeoxycholic acid on cytosolic Ca2+ signals in isolated rat hepatocytesQ42509692
Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver.Q42516280
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.Q42558480
Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liverQ42797129
Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transportQ42805771
Cell cycle-dependent activation of Ras.Q42806454
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survivalQ42828483
The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systemsQ43832144
Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytesQ44946866
Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.Q44951192
Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man.Q45104953
Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content.Q50784679
Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity.Q51560255
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.Q52538724
Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth FactorQ58197226
Tauroursodeoxycholate and S-adenosyl-L-methionine exert an additive ameliorating effect on taurolithocholate-induced cholestasis: A study in isolated rat hepatocyte coupletsQ61952468
Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo-controlled trialQ68019501
Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind trialQ69357047
Tauroursodeoxycholate prevents taurocholate induced cholestasisQ70316364
Molecular aspects of membrane stabilization by ursodeoxycholate [see comment]Q70457384
Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivoQ71011188
Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytesQ71035961
Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor-regulated pathways leading to activation of mitogen-activated protein kinase in rat hepatocytesQ71057946
Ursodeoxycholic acid in the treatment of primary biliary cirrhosisQ72401649
Parallel decrease of Na(+)-taurocholate cotransport and its encoding mRNA in primary cultures of rat hepatocytesQ72567629
Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liverQ73760652
Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membraneQ73835478
Effect of S-adenosylmethionine versus tauroursodeoxycholic acid on bile acid-induced apoptosis and cytolysis in rat hepatocytesQ77190586
The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liverQ77359791
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)207-213
P577publication date2000-08-01
P1433published inBiochemical JournalQ864221
P1476titlePhosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver
P478volume350 Pt 1

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cites work (P2860)
Q46422164A nuclear receptor ligand down-regulates cytosolic phospholipase A2 expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: implications of anticarcinogenic action of farnesoid X receptor agonists
Q36506491Bile acid interactions with cholangiocytes
Q33881922Bile formation and secretion
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Q34687676Drug therapy of primary biliary diseases: classical and modern strategies.
Q37341910Dynamic localization of hepatocellular transporters in health and disease.
Q34482125ERK1/2 and p38 MAPKs are complementarily involved in estradiol 17ß-D-glucuronide-induced cholestasis: crosstalk with cPKC and PI3K.
Q34448448INTRACELLULAR SIGNALING BY BILE ACIDS.
Q44429825Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis
Q45971853Mechanisms of tauroursodeoxycholate-mediated inhibition of apoptosis.
Q42129552Osmotic regulation of insulin-induced mitogen-activated protein kinase phosphatase (MKP-1) expression in H4IIE rat hepatoma cells
Q41034426Regulation of plasma membrane localization of the Na+-taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate
Q44355362Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
Q35098259The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure
Q37919924Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications.

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