Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.

scientific article published on October 1994

Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit. is …
instance of (P31):
scholarly articleQ13442814

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P698PubMed publication ID7523383

P50authorJean-Marc TaymansQ30112411
Jozef AnnéQ51060624
P2093author name stringDe Clercq E
Desmyter J
Balzarini J
Camarasa MJ
Jonckheere H
Velázquez S
P433issue41
P407language of work or nameEnglishQ1860
P304page(s)25255-25258
P577publication date1994-10-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleResistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit
P478volume269

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cites work (P2860)
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Q34163065Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding
Q36969977Effect of mutations at position E138 in HIV-1 reverse transcriptase and their interactions with the M184I mutation on defining patterns of resistance to nonnucleoside reverse transcriptase inhibitors rilpivirine and etravirine
Q43804442Insertion of a peptide from MuLV RT into the connection subdomain of HIV-1 RT results in a functionally active chimeric enzyme in monomeric conformation
Q24796883Insertion of a small peptide of six amino acids into the beta7-beta8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
Q33588535Managing resistance to anti-HIV drugs: an important consideration for effective disease management.
Q34671582Pausing of reverse transcriptase on retroviral RNA templates is influenced by secondary structures both 5' and 3' of the catalytic site
Q34438247Subunit-specific analysis of the human immunodeficiency virus type 1 reverse transcriptase in vivo.

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