Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy

scientific article published on 14 August 2013

Effect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/PHAR.1341
P698PubMed publication ID23946152

P2093author name stringPatrick F Smith
Peter N Morcos
Barbara J Brennan
Mercidita T Navarro
Sebastian A Moreira
Nuria Bech
P2860cites workTwo New Rating Scales for Opiate WithdrawalQ58291436
Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)Q27487391
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002Q29619974
Sofosbuvir for previously untreated chronic hepatitis C infectionQ29620137
Changes in plasma protein binding have little clinical relevanceQ34119864
Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadoneQ34348923
Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadoneQ34403471
Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.Q34543319
Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavirQ34604652
Hepatitis C virus and human immunodeficiency virus-1 co-infection in former heroin addicts in methadone maintenance treatmentQ34893342
Population pharmacokinetics of (R)-, (S)- and rac-methadone in methadone maintenance patients.Q35826204
Steady-state pharmacokinetics of (R)- and (S)-methadone in methadone maintenance patients.Q36053982
Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavirQ36593838
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearanceQ36641884
Methadone maintenance treatment in opiate dependence: a review.Q36887595
Critical issues in the treatment of hepatitis C virus infection in methadone maintenance patientsQ37142229
Induction effects of ritonavir: implications for drug interactionsQ37199533
Methadone: a review of drug-drug and pathophysiological interactionsQ37950478
New direct-acting antiviral agents for the treatment of hepatitis C virus infection and perspectivesQ38002789
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic painQ39538201
Correlates of hepatitis C virus infections among injection drug users.Q40453200
Hepatitis C in methadone maintenance patients: prevalence and public policy implicationsQ42646672
Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjectsQ42660244
Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behaviorQ42985263
Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN α-2a/RBV in hepatitis C patientsQ43034694
Pharmacokinetic interactions between darunavir/ritonavir and opioid maintenance therapy using methadone or buprenorphine/naloxoneQ44346297
Impact of low-dose ritonavir on danoprevir pharmacokinetics: results of computer-based simulations and a clinical drug-drug interaction studyQ44501592
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patientsQ44540993
Mechanism-based inactivation of CYP3A by HIV protease inhibitorsQ45137041
Effect of saquinavir/ritonavir (1000/100 mg bid) on the pharmacokinetics of methadone in opiate-dependent HIV-negative patients on stable methadone maintenance therapy.Q45971154
Pharmacokinetic interaction of nelfinavir and methadone in intravenous drug usersQ46154281
Role of CYP2B6 in stereoselective human methadone metabolismQ46739706
HIV protease inhibitor ritonavir: a more potent inhibitor of P-glycoprotein than the cyclosporine analog SDZ PSC 833.Q48965078
Pharmacokinetics of a three-way drug interaction between danoprevir, ritonavir and the organic anion transporting polypeptide (OATP) inhibitor ciclosporin.Q50956303
Viral infections in short-term injection drug users: the prevalence of the hepatitis C, hepatitis B, human immunodeficiency, and human T-lymphotropic viruses.Q55240560
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectritonavirQ422618
Hepatitis C virusQ708693
pharmacokineticsQ323936
danoprevirQ27271364
P1104number of pages7
P304page(s)220-226
P577publication date2013-08-14
P1433published inPharmacotherapyQ7180800
P1476titleEffect of ritonavir-boosted danoprevir, a potent hepatitis C virus protease inhibitor, on the pharmacokinetics of methadone in healthy subjects undergoing methadone maintenance therapy
P478volume34

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cites work (P2860)
Q59354367Danoprevir: First Global Approval
Q91386089Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review

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