Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region

scientific article published on 3 April 2011

Tristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1089/JIR.2010.0154
P932PMC publication ID3151618
P698PubMed publication ID21457063
P5875ResearchGate publication ID50986108

P2093author name stringMin Liu
Nisha J D'Silva
Keith L Kirkwood
Wenpu Zhao
P2860cites workEvidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA.Q22010036
AU binding proteins recruit the exosome to degrade ARE-containing mRNAsQ24291926
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanismsQ24292426
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayQ24316111
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolinQ24323168
Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnoverQ24534314
Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1Q28118675
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathwayQ28350388
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stabilityQ28508664
Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interferenceQ28589337
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiencyQ28589649
Structure/function analysis of tristetraprolin (TTP): p38 stress-activated protein kinase and lipopolysaccharide stimulation do not alter TTP functionQ28609872
p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblastsQ33947764
Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elementsQ34065213
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone lossQ34702307
Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?Q35003449
The AU-rich transcriptome: more than interferons and cytokines, and its role in disease.Q36026396
Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinomaQ36616576
Rapid transit in the immune cells: the role of mRNA turnover regulation.Q36776927
p38 MAPK signaling in oral-related diseasesQ36919722
The blockade of IL-6 signaling in rational drug designQ37160974
Control of mRNA decay by phosphorylation of tristetraprolin.Q37164616
Cytokines in colitis associated cancer: potential drug targets?Q37265020
Targeting mRNA stability arrests inflammatory bone lossQ37364464
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Interleukin-6 as a therapeutic target in candidate inflammatory diseasesQ37698197
The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeatQ38336281
ARED 2.0: an update of AU-rich element mRNA database.Q38430539
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.Q39655080
A dominant function of p38 mitogen-activated protein kinase signaling in receptor activator of nuclear factor-kappaB ligand expression and osteoclastogenesis induction by Aggregatibacter actinomycetemcomitans and Escherichia coli lipopolysaccharideQ40008685
Establishment of a new interleukin-6 (IL-6) receptor inhibitor applicable to the gene therapy for IL-6-dependent tumorQ40174280
Actinobacillus actinomycetemcomitans lipopolysaccharide induces interleukin-6 expression through multiple mitogen-activated protein kinase pathways in periodontal ligament fibroblastsQ40215927
MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cellsQ40221732
Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1Q40620791
Gene suppression by tristetraprolin and release by the p38 pathwayQ40795321
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.Q41850515
p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elementsQ42049265
Serum levels of interleukin 6 and stress related substances indicate mental stress condition in patients with rheumatoid arthritis.Q43571084
A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA.Q44467307
AU-rich transient response transcripts in the human genome: expressed sequence tag clustering and gene discovery approach.Q45241844
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stabilityQ73520889
Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinomaQ77357301
A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone lossQ79240430
P433issue8
P921main subjectinterleukinsQ194908
P304page(s)629-637
P577publication date2011-04-03
P1433published inJournal of Interferon and Cytokine ResearchQ15754749
P1476titleTristetraprolin regulates interleukin-6 expression through p38 MAPK-dependent affinity changes with mRNA 3' untranslated region
P478volume31

Reverse relations

cites work (P2860)
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