Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase

scientific article published on 22 April 2012

Ultrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCHEMBIO.941
P932PMC publication ID3433955
P698PubMed publication ID22522319
P5875ResearchGate publication ID224810858

P2093author name stringJoshua D Rabinowitz
Xiao-Jiang Feng
Marshall Louis Reaves
Daniel Amador-Noguez
Yi-Fan Xu
P2860cites workConstruction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
The shikimate pathway as an entry to aromatic secondary metabolismQ24673312
Structural and Biochemical Characterization of the Type II Fructose-1,6-bisphosphatase GlpX from Escherichia coliQ27653112
Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometerQ27932159
Phosphoenolpyruvate carboxylase: three-dimensional structure and molecular mechanismsQ28208070
Kinetics and regulation of pantothenate kinase from Escherichia coliQ28239024
Regulation of Escherichia coli phosphoenolpyruvate carboxylase by multiple effectors in vivo. Estimation of the activities in the cells grown on various compoundsQ28276343
Metabolomics – the link between genotypes and phenotypesQ28540942
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growthQ29547680
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coliQ29615316
A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic informationQ29615371
Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological researchQ29619122
Bacterial adaptation through distributed sensing of metabolic fluxesQ34102801
Phosphoenolpyruvate carboxylase of Escherichia coli. Purification and some propertiesQ34212546
The story of glutamine synthetase regulationQ34518113
Multiple high-throughput analyses monitor the response of E. coli to perturbationsQ34578020
Compounds Which Serve as the Sole Source of Carbon or Nitrogen for Salmonella typhimurium LT-2Q35157309
Conservation of the metabolomic response to starvation across two divergent microbesQ35220056
The role of dynamics in allosteric regulationQ35607757
Phosphoenolpyruvate carboxylase: a new era of structural biology.Q36051372
The PEP-pyruvate-oxaloacetate node as the switch point for carbon flux distribution in bacteriaQ36231163
Phosphorylation of Isocitrate Dehydrogenase of Escherichia coliQ39240952
Analytical strategies for LC-MS-based targeted metabolomicsQ41824102
Differentiating metabolites formed from de novo synthesis versus macromolecule decompositionQ41970313
Kinetic flux profiling for quantitation of cellular metabolic fluxesQ42235425
Large-scale 13C-flux analysis reveals distinct transcriptional control of respiratory and fermentative metabolism in Escherichia coliQ42733469
The quaternary structure of pyruvate kinase type 1 from Escherichia coli at low nanomolar concentrationsQ43267611
Global expression profiling of acetate-grown Escherichia coliQ43869546
Concerted Regulation in Vitro of Phosphoenolpyruvate Carboxylase from Escherichia coliQ44036638
Global metabolic regulation analysis for Escherichia coli K12 based on protein expression by 2-dimensional electrophoresis and enzyme activity measurementQ44374961
Metabolic flux analysis of pykF gene knockout Escherichia coli based on 13C-labeling experiments together with measurements of enzyme activities and intracellular metabolite concentrationsQ44475462
A novel metabolic cycle catalyzes glucose oxidation and anaplerosis in hungry Escherichia coli.Q44578300
Steady-State Kinetics and Molecular Evolution of Escherichia coli MenD [(1R,6R)-2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate Synthase], an Anomalous Thiamin Diphosphate-Dependent Decarboxylase−CarboligaseQ44657928
Effect of zwf gene knockout on the metabolism of Escherichia coli grown on glucose or acetateQ44868976
Effect of a pyruvate kinase (pykF-gene) knockout mutation on the control of gene expression and metabolic fluxes in Escherichia coli.Q44906594
Maize phosphoenolpyruvate carboxylase. Mutations at the putative binding site for glucose 6-phosphate caused desensitization and abolished responsiveness to regulatory phosphorylation.Q45234606
In vivo dynamics of glycolysis in Escherichia coli shows need for growth-rate dependent metabolome analysisQ46132589
Dihydroorotase from Escherichia coli: loop movement and cooperativity between subunits.Q46434703
Regulation of the activity of phosphoenolypyruvate carboxylase by fructose diphosphateQ50255166
Acidic acetonitrile for cellular metabolome extraction from Escherichia coli.Q54438002
Inhibitory effect of phosphoenolpyruvate on glycolytic enzymes in Escherichia coli.Q54446566
Essential cysteines in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase from Escherichia coli: analysis by chemical modification and site-directed mutagenesis.Q54585476
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
Cooperative binding of the feedback modifiers isoleucine and valine to biosynthetic threonine deaminase from Escherichia coli.Q54623696
Branch point control by the phosphorylation state of isocitrate dehydrogenase. A quantitative examination of fluxes during a regulatory transition.Q54794994
Fluorescence studies of threonine-promoted conformational transitions in aspartokinase I using the substrate analogue 2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-triphosphateQ70170022
Regulation of Escherichia coli phosphoenolpyruvate carboxylase by multiple effectors in vivo. II. Kinetic studies with a reaction system containing physiological concentrations of ligandsQ70225707
Phosphoenolpyruvate Carboxylase of Escherichia coli. Specificity of Some Compounds as Activators at the Site for Fructose 1,6-Bisphosphate, One of the Allosteric Effectors12Q70355121
In vivo analysis of metabolic dynamics in Saccharomyces cerevisiae : I. Experimental observationsQ81660481
Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiGQ82985749
P433issue6
P304page(s)562-568
P577publication date2012-04-22
P1433published inNature Chemical BiologyQ904026
P1476titleUltrasensitive regulation of anapleurosis via allosteric activation of PEP carboxylase
P478volume8

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cites work (P2860)
Q38603207A Key Regulator of the Glycolytic and Gluconeogenic Central Metabolic Pathways in Sinorhizobium meliloti.
Q35834574A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli
Q28546338A general framework for thermodynamically consistent parameterization and efficient sampling of enzymatic reactions
Q27332293A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria
Q27003299A roadmap for interpreting (13)C metabolite labeling patterns from cells
Q42128848Allosteric Activation of Escherichia coli Glucosamine-6-Phosphate Deaminase (NagB) In Vivo Justified by Intracellular Amino Sugar Metabolite Concentrations
Q43141650CceR and AkgR regulate central carbon and energy metabolism in alphaproteobacteria
Q36727448Central Role of Pyruvate Kinase in Carbon Co-catabolism of Mycobacterium tuberculosis
Q27329738Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach.
Q38198495Coordination of microbial metabolism
Q92205063Developing a pyruvate-driven metabolic scenario for growth-coupled microbial production
Q53237921Engineering of a hybrid route to enhance shikimic acid production in Corynebacterium glutamicum.
Q38849947Environmental dependence of stationary-phase metabolism in Bacillus subtilis and Escherichia coli
Q28536139Flux imbalance analysis and the sensitivity of cellular growth to changes in metabolite pools
Q35602663Futile cycling increases sensitivity toward oxidative stress in Escherichia coli
Q40043349Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity
Q37404986Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum
Q37017244Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
Q38261448Microfluidic single-cell analysis links boundary environments and individual microbial phenotypes
Q64102332Minor Isozymes Tailor Yeast Metabolism to Carbon Availability
Q28543399Monte-Carlo modeling of the central carbon metabolism of Lactococcus lactis: insights into metabolic regulation
Q90243145Near-equilibrium glycolysis supports metabolic homeostasis and energy yield
Q27934673Nucleotide degradation and ribose salvage in yeast
Q35610380Optimal programs of pathway control: dissecting the influence of pathway topology and feedback inhibition on pathway regulation.
Q48047617Plasmid-encoded biosynthetic genes alleviate metabolic disadvantages while increasing glucose conversion to shikimate in an engineered Escherichia coli strain
Q51133363Precise precursor rebalancing for isoprenoids production by fine control of gapA expression in Escherichia coli.
Q38835548Real-time metabolome profiling of the metabolic switch between starvation and growth
Q34585187Reciprocal control of anaplerotic phosphoenolpyruvate carboxylase by in vivo monoubiquitination and phosphorylation in developing proteoid roots of phosphate-deficient harsh hakea
Q86253778Systematic identification of allosteric protein-metabolite interactions that control enzyme activity in vivo
Q52597727The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase.
Q40093005Transcriptional regulation is insufficient to explain substrate-induced flux changes in Bacillus subtilis

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