Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs.

scientific article published on 29 July 2017

Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00395-017-0643-0
P932PMC publication ID5534204
P698PubMed publication ID28756533

P50authorFletcher A WhiteQ59694320
Eleni BeliQ42709533
Alexander G. ObukhovQ47151348
Maria B GrantQ88523403
P2093author name stringMichael Sturek
S Christopher Hiett
Wennan Li
Xingjuan Chen
Saikat Chakraborty
Xin Long
Constance J Temm
Mouhamad Alloosh
Ashley M Riley
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CD40 in coronary artery disease: a matter of macrophages?Q26752784
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Aldosterone inhibition limits collagen synthesis and progressive left ventricular enlargement after anterior myocardial infarction.Q31795978
Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosisQ33573616
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PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 ActivityQ33883861
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Mechanisms underlying capsaicin effects in canine coronary artery: implications for coronary spasmQ34354310
Higher blood aldosterone level in metabolic syndrome is independently related to adiposity and fasting plasma glucose.Q34997841
Bromoenol lactone inhibits voltage-gated Ca2+ and transient receptor potential canonical channelsQ35430018
Novel Roles for Kv7 Channels in Shaping Histamine-Induced Contractions and Bradykinin-Dependent Relaxations in Pig Coronary ArteriesQ36546867
Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanismQ36701794
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Plasma aldosterone is independently associated with the metabolic syndrome.Q51496145
The Effect of Spironolactone on Lipid, Glucose and Uric Acid Levels in Blood during Long-Term Administration to HypertensivesQ51648724
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Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesionQ37003229
Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasiaQ37079233
Canonical transient receptor potential channels expression is elevated in a porcine model of metabolic syndromeQ37176258
Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesityQ37351398
Identification of canonical transient receptor potential (TRPC) channel proteins in native vascular smooth muscle cells.Q37411376
Adventitial nab-rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial inflammationQ37463102
Macrophages and immune cells in atherosclerosis: recent advances and novel conceptsQ38462573
TRPC5 channels undergo changes in gating properties during the activation-deactivation cycleQ38626089
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Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exerciseQ39394306
Intravascular ultrasound detection of atherosclerosis at the site of focal vasospasm in angiographically normal or minimally narrowed coronary segmentsQ39486793
FAD286, an aldosterone synthase inhibitor, reduced atherosclerosis and inflammation in apolipoprotein E-deficient miceQ39668789
Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient miceQ44459362
Effects of aldosterone on human atherosclerosis: plasma aldosterone and progression of carotid plaqueQ44695581
Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2.Q45225378
Murine "model" monotheism: an iconoclast at the altar of mouseQ46643118
Association of adrenal steroids with hypertension and the metabolic syndrome in blacksQ46715413
Molecular Determinants of the Sensitivity to Gq/11-Phospholipase C-dependent Gating, Gd3+ Potentiation, and Ca2+ Permeability in the Transient Receptor Potential Canonical Type 5 (TRPC5) ChannelQ48179404
Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failureQ49106538
Increased adventitial mast cells in a patient with coronary spasmQ68943619
Coronary artery spasm induced in atherosclerotic miniature swineQ70439239
Elevation of the plasma histamine concentration in the coronary circulation in patients with variant anginaQ71112099
Quantitative pharmacologic responses of normal and atherosclerotic isolated human epicardial coronary arteriesQ71250471
Effect of spironolactone on blood pressure in subjects with resistant hypertensionQ79798622
Enhancement of receptor-operated cation current and TRPC6 expression in arterial smooth muscle cells of deoxycorticosterone acetate-salt hypertensive ratsQ79918516
TRP channels in diseaseQ79972966
Arterial stiffness, intima-media thickness and carotid artery fibrosis in patients with primary aldosteronismQ82603650
Influence of spironolactone treatment on endothelial function in non-obese women with polycystic ovary syndromeQ82880351
Aldosterone, atherosclerosis and vascular events in patients with stable coronary artery diseaseQ84444965
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmetabolic syndromeQ657193
vasoconstrictionQ1067506
atherosclerosisQ12252367
P304page(s)54
P577publication date2017-07-29
P1433published inBasic Research in CardiologyQ2453360
P1476titleLong-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs
P478volume112

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cites work (P2860)
Q93037250Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes
Q57177158Ion Channels and Transporters in Inflammation: Special Focus on TRP Channels and TRPC6
Q64078980LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway
Q64092250Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis
Q57750179Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling
Q88959338Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer
Q92258015Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes
Q89468002TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Q61805302The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction

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