Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts

scientific article published on 22 July 2013

Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/MRM.24869
P698PubMed publication ID23878023

P50authorSiver Andreas MoestueQ42637173
Tone F. BathenQ61104171
Ingrid Susann GribbestadQ65706743
Gunhild M. MælandsmoQ76257274
Morteza EsmaeiliQ101578666
Olav EngebråtenQ114422039
P2860cites workGene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsQ27860709
Molecular portraits of human breast tumoursQ28032461
The emerging mechanisms of isoform-specific PI3K signallingQ29617954
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activityQ29618117
Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasisQ30514230
Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivoQ31009512
Tumour phospholipid metabolismQ33179622
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cellsQ33564297
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft modelsQ33660965
Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cellsQ33699139
Evaluation of the ERETIC method as an improved quantitative reference for 1H HR-MAS spectroscopy of prostate tissueQ33890692
The phosphoinositide 3-kinase inhibitor PI-103 downregulates choline kinase alpha leading to phosphocholine and total choline decrease detected by magnetic resonance spectroscopy.Q33959529
In vivo MRS of locally advanced breast cancer: characteristics related to negative or positive choline detection and early monitoring of treatment responseQ34016780
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapyQ34140986
17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2Q34989144
In vivo proton magnetic resonance spectroscopy of breast cancer: a review of the literatureQ36245493
Mouse models in oncogenesis and cancer therapy.Q36499581
Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancerQ36903072
Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy.Q37100440
Triple-negative breast cancer: present challenges and new perspectivesQ37764168
Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluationQ37779171
Does the PI3K pathway play a role in basal breast cancer?Q37813284
Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopyQ37871191
Targeting the PI3K signaling pathway in cancer therapyQ37975242
PI3K and MEK inhibitor combinations: examining the evidence in selected tumor typesQ38084846
Increases in NMR-visible lipid and glycerophosphocholine during phenylbutyrate-induced apoptosis in human prostate cancer cells.Q40428146
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft modelsQ41128277
Modulation of MR-visible mobile lipid levels by cell culture conditions and correlations with chemotactic responseQ41238551
Glycerol 3-phosphate and lactate as indicators of the cerebral cytoplasmic redox state in severe and mild hypoxia respectively: a 13C- and 31P-n.m.r. studyQ41829015
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopyQ41939336
Investigation of metabolite changes in the transition from pre-invasive to invasive cervical cancer measured using (1)H and (31)P magic angle spinning MRS of intact tissueQ44545551
31P NMR of phospholipid metabolites in prostate cancer and benign prostatic hyperplasiaQ44673076
1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis.Q45863255
High-resolution magic-angle-spinning 1H NMR spectroscopy reveals different responses in choline-containing metabolites upon gene therapy-induced programmed cell death in rat brain glioma.Q45883454
Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parametersQ46756319
Identification of magnetic resonance detectable metabolic changes associated with inhibition of phosphoinositide 3-kinase signaling in human breast cancer cellsQ46908003
Evaluation of 31P high-resolution magic angle spinning of intact tissue samplesQ48449228
Use of Voigt lineshape for quantification of in vivo 1H spectraQ48722469
Predicting long-term survival and treatment response in breast cancer patients receiving neoadjuvant chemotherapy by MR metabolic profiling.Q51541687
Concentration measurements by PULCON using X-filtered or 2D NMR spectraQ57825681
Measuring Protein Concentrations by NMR SpectroscopyQ57825691
P433issue6
P921main subjectxenograftQ64148587
P304page(s)1973-1981
P577publication date2013-07-22
P1433published inMagnetic Resonance in MedicineQ6731496
P1476titleQuantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts
P478volume71

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cites work (P2860)
Q37474359Effects of tyrosine kinase inhibitors and CXCR4 antagonist on tumor growth and angiogenesis in rat glioma model: MRI and protein analysis study.
Q26751944Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS)
Q64252558HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer
Q57095807High-resolution magic-angle-spinning NMR spectroscopy of intact tissue
Q36822535Intratumoral Agreement of High-Resolution Magic Angle Spinning Magnetic Resonance Spectroscopic Profiles in the Metabolic Characterization of Breast Cancer
Q36918102MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival.
Q58086874Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma
Q40403745Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression
Q40071956Pitfalls to be considered on the metabolomic analysis of biological samples by HR-MAS.
Q37660266Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation
Q42120404Probing the PI3K/Akt/mTor pathway using (31)P-NMR spectroscopy: routes to glycogen synthase kinase 3.

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