Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells

scientific article published on 24 September 2008

Effects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VPH.2008.09.001
P698PubMed publication ID18849010
P5875ResearchGate publication ID23313553

P2093author name stringDavid Langleben
Gregory P Star
Michele Giovinazzo
P2860cites workAltered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteinsQ24291557
Transforming growth factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMPQ28570528
Clinical classification of pulmonary hypertension.Q30341846
BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertensionQ34043809
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.Q34085780
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II geneQ34142690
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertensionQ34294101
Cellular and molecular pathobiology of pulmonary arterial hypertensionQ35803229
Pathologic assessment of vasculopathies in pulmonary hypertensionQ35803235
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talkQ36116637
Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?Q36634716
Endothelin receptor antagonists in the treatment of pulmonary arterial hypertensionQ36752321
Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studiesQ37087907
Inhibitory Smad transcription factors protect arterial endothelial cells from apoptosis induced by BMP4.Q40274237
An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertensionQ41123021
Bone morphogenetic protein receptorsQ41270251
Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension.Q42539051
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.Q42823613
Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.Q53644055
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.Q54237894
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?Q54299949
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertensionQ55670914
Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cellsQ69492102
Endothelins and the lungQ71540420
Endothelin-1 expression in long-term cultures of fetal rat calvarial osteoblasts: regulation by BMP-7Q73670457
Bosentan therapy for pulmonary arterial hypertensionQ77801473
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertensionQ77822568
Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertensionQ77933091
Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferationQ80005826
Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathwayQ81663164
Etiology-specific endothelin-1 clearance in human precapillary pulmonary hypertensionQ82828631
Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentanQ83334055
P433issue1-2
P921main subjectendotheliumQ111140
P304page(s)45-50
P577publication date2008-09-24
P1433published inVascular PharmacologyQ7916446
P1476titleEffects of bone morphogenic proteins and transforming growth factor-beta on In-vitro production of endothelin-1 by human pulmonary microvascular endothelial cells
P478volume50

Reverse relations

cites work (P2860)
Q42870658Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma
Q54718275Interaction between bone morphogenetic proteins and endothelin-1 in human pulmonary artery smooth muscle.
Q42467860Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension
Q90745453Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension
Q99711717Panax notoginseng saponins alleviates advanced glycation end product-induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs
Q33712505TGF beta and IL13 in Schistosomiasis mansoni associated pulmonary arterial hypertension; a descriptive study with comparative groups
Q36049930Transforming growth factor beta 1 induced endothelin-1 release is peroxisome proliferator-activated receptor gamma dependent in A549 cells
Q36563572Transforming growth factor-β inhibition and endothelin receptor blockade in rats with monocrotaline-induced pulmonary hypertension.
Q35994476Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure