An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint

scientific article published on April 2004

An inflammation-inducible adenoviral expression system for local treatment of the arthritic joint is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1020812619
P356DOI10.1038/SJ.GT.3302182
P8608Fatcat IDrelease_wj3e3pvxdbdl3cxbf6xwm75wgi
P698PubMed publication ID14973543

P2093author name stringJoosten LA
van den Berg WB
Varley AW
van Beuningen HM
Arntz OJ
Bakker AC
Bennink MB
de Hooge AS
Smeets RL
van de Loo FA
van der Kraan PK
P2860cites workCpG methylation, chromatin structure and gene silencing-a three-way connectionQ24533302
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6Q24563031
The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT proteinQ24680024
Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency.Q33919346
Toll-like receptors: key mediators of microbe detection.Q34493051
Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulatorsQ34526913
Endogenous regulation of a therapeutic transgene restores homeostasis in arthritic jointsQ34791340
Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretionQ36400734
Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectorsQ36575731
A 58-base-pair region of the human C3 gene confers synergistic inducibility by interleukin-1 and interleukin-6.Q36773864
Stimulation of the human cytomegalovirus IE enhancer/promoter in HL-60 cells by TNFalpha is mediated via induction of NF-kappaB.Q38296897
Inhibition of tumor necrosis factor alpha by an adenovirus-encoded soluble fusion protein extends transgene expression in the liver and lungQ39594251
Functional and selective targeting of adenovirus to high-affinity Fcgamma receptor I-positive cells by using a bispecific hybrid adapterQ39601286
Molecular mechanisms of gene silencing mediated by DNA methylationQ39674525
Anti-TNF alpha monoclonal antibodies (infliximab) and tuberculosis: apropos of 3 casesQ40585448
Polymerase chain reaction for rapid diagnosis of respiratory adenovirus infectionQ40671571
Phenotypic differences in murine chondrocyte cell lines derived from mature articular cartilageQ40685849
Comparative study and identification of potent eukaryotic transcriptional repressors in gene switch systemsQ40722269
Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expressionQ41074143
A nitric oxide production bioassay for interferon-gammaQ41151346
Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.Q41237683
Tumour necrosis factor alpha stimulates the activity of the human cytomegalovirus major immediate early enhancer/promoter in immature monocytic cellsQ41516547
Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 geneQ41625429
Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement componentQ41839042
Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the kneeQ42801221
C3-Tat/HIV-regulated intraarticular human interleukin-1 receptor antagonist gene therapy results in efficient inhibition of collagen-induced arthritis superior to cytomegalovirus-regulated expression of the same transgeneQ43907092
Inactivation of the very strong HCMV immediate early promoter by DNA CpG methylation in vitroQ44644063
Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonistQ45744151
Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced th2activityQ45864635
Stimulatory and inhibitory action of cytokines on the regulation of hCMV-IE promoter activity in human endothelial cellsQ45869823
Demonstration of infectious DNA in transformed cells. III. Correlation of detection of infectious DNA-protein complexes with persistence of virus in simian adenovirus SA7-induced tumor cellsQ45883122
A two-component expression system that responds to inflammatory stimuli in vivoQ45883791
Inhibition of tumor necrosis factor alpha decreases inflammation and prolongs adenovirus gene expression in lung and liverQ45889223
Physiologically responsive gene therapyQ45889739
Onset of multiple sclerosis associated with anti-TNF therapyQ48704019
Impaired immune and acute-phase responses in interleukin-6-deficient mice.Q52514391
Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production.Q53966152
Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferationQ61955148
Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasLQ64378360
Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4Q64380123
Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritisQ71503443
Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritisQ71750740
Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritisQ72526685
Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokinesQ74148432
Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritisQ77403524
Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatmentQ77844025
Intraarticular gene transfer of TNFR:Fc suppresses experimental arthritis with reduced systemic distribution of the gene productQ78709124
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
inflammationQ101991
P304page(s)581-590
P577publication date2004-04-01
P1433published inGene TherapyQ15763095
P1476titleAn inflammation-inducible adenoviral expression system for local treatment of the arthritic joint
P478volume11

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cites work (P2860)
Q92994177A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues
Q39450777A novel hybrid promoter responsive to pathophysiological and pharmacological regulation
Q42824694Application of a disease-regulated promoter is a safer mode of local IL-4 gene therapy for arthritis.
Q42084870Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application
Q37000837Cells of the synovium in rheumatoid arthritis. Chondrocytes
Q35834491Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimenta
Q33713191Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis
Q34482730Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice
Q34169584Early gestational gene transfer of IL-10 by systemic administration of lentiviral vector can prevent arthritis in a murine model
Q38829316Efficient expression of bioactive murine IL12 as a self-processing P2A polypeptide driven by inflammation-regulated promoters in tumor cell lines.
Q59359723Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model
Q80448411Gene therapy for arthritis
Q35906093Gene therapy for autoimmune diseases: quo vadis?
Q36920198Gene therapy in The Netherlands: highlights from the Low Countries
Q24796801Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?
Q37207021Gene therapy of the rheumatic diseases: 1998 to 2008.
Q36594242Gene therapy works in animal models of rheumatoid arthritis...so what!
Q30980638Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation
Q47697061Genome Engineering for Personalized Arthritis Therapeutics
Q42278257Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs
Q36512506IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis
Q40132461Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression
Q41036628Local delivery of beta interferon using an adeno-associated virus type 5 effectively inhibits adjuvant arthritis in rats
Q33713231Orthopedic gene therapy in 2008.
Q34543292PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes
Q45859107Targeted gene therapy of autoimmune diseases: advances and prospects
Q36577437Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis.

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